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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
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Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms.
Carlos Cruchaga,Jorge Del aguila,Benjamin Saef,Kathleen Black,Maria Victoria Fernandez,John P. Budde,Laura Ibanez,Yuetiva Deming,Manav Kapoor,Giuseppe Tosto,Richard Mayeux,Richard Mayeux,David M. Holtzman,Anne M. Fagan,John C. Morris,Randall J. Bateman,Alison Goate,Oscar Harari +17 more
TL;DR: To determine whether the extent of overlap of the genetic architecture among the sporadic late‐onset Alzheimer's Disease (sLOAD), familial late-onset AD (fLOAD), sporadic early‐onsets AD (sEOAD), and autosomal dominant early‐onset AD (eADAD) is overlap, a large number of patients with both sporadic and familial histories of AD are surveyed.
TREM2 is associated with increased risk for Alzheimer's disease in African Americans
Sheng Chih Jin,Minerva M. Carrasquillo,Bruno A. Benitez,Tara Skorupa,David Carrell,Dwani Patel,Sarah Lincoln,Siddharth Krishnan,Michaela Kachadoorian,Christiane Reitz,Richard Mayeux,Thomas S. Wingo,Thomas S. Wingo,James J. Lah,Allan I. Levey,Jill R. Murrell,Hugh C. Hendrie,Hugh C. Hendrie,Tatiana Foroud,Neill R. Graff-Radford,Alison Goate,Carlos Cruchaga,Nilufer Ertekin-Taner +22 more
TL;DR: TREM2 coding variants also confer LOAD risk in AA, but implicate variants within different regions of the gene than those identified for Caucasian subjects, which underscores the importance of investigating different ethnic populations for disease risk variant discovery.
Journal ArticleDOI
C9orf72 hexanucleotide repeat expansions in clinical Alzheimer disease.
Matthew B. Harms,Bruno A. Benitez,Nigel J. Cairns,Breanna Cooper,Paul R. Cooper,Kevin Mayo,David Carrell,Kelley Faber,Jennifer Williamson,Thomas D. Bird,Ramon Diaz-Arrastia,Tatiana Foroud,Bradley F. Boeve,Neill R. Graff-Radford,Richard Mayeux,Sumitra Chakraverty,Alison Goate,Carlos Cruchaga +17 more
TL;DR: C9orf72 repeat expansions explain a small proportion of patients with a clinical presentation indistinguishable from AD, and they highlight the necessity of screening frontotemporal dementia genes in clinical AD cases with strong family history.
Journal ArticleDOI
A Family-Based Analysis of Whether the Functional Promoter Alleles of the Serotonin Transporter Gene HTT Affect the Risk for Alcohol Dependence
Howard J. Edenberg,Jennifer L. Reynolds,Daniel L. Koller,Henri Begleiter,Kathleen K. Bucholz,P. Michael Conneally,Raymond R. Crowe,Alison Goate,Victor Hesselbrock,Ting-Kai Li,John I. Numberger,Bernice Porjesz,Theodore Reich,John P. Rice,Marc A. Schuckit,Jay A. Tischfield,Tatiana Foroud +16 more
TL;DR: Application of the transmission disequilibrium test did not provide support for either linkage or association between this functional polymorphism and alcohol dependence; there was no significant bias in the transmission of either allele to the alcohol-dependent offspring.
Journal ArticleDOI
Chromosome 14–encoded Alzheimer's disease: Genetic and clinicopathological description
Matti Haltia,Matti Viitanen,Raimo Sulkava,Veli Ala‐Hurula,Minna Pöyhönen,Lev G. Goldfarb,Paul Brown,Efrat Levy,Henry Houlde,Henry Houlde,Richard Crook,Alison Goate,Robert Clark,Kevin M. Korenblat,Sunil D. Pandit,Helen Donis Keller,Lena Llius,Li Liu,Karin Axelman,Lotta Forsell,Bengt Winblad,Lars Lannfelt,John Hardy +22 more
TL;DR: A family of Finnish descent with very‐early‐onset Alzheimer's disease has been identified, and genetic analysis of this family eliminated the amyloid precursor protein gene as the pathogenic locus, but strongly implicated a locus on chromosome 14q23.4 between D 14S52 and D14S55.