Alison Goate

TL;DR: Gene-based tests demonstrate variants in TREM2 are genome-wide significantly associated with AD, and gel electrophoresis analysis confirms that at least three T REM2 transcripts are expressed in human brains, including one encoding a soluble form of TREM1.

TL;DR: Cognitively normal sedentary APOE ε4-positive individuals may be at augmented risk for cerebral amyloid deposition, and a novel interaction between APOE status and exercise engagement for [(11)C]PiB binding is observed.

TL;DR: In the white series of cases, PS-1 accounted for about half as much of the risk for late-onset Alzheimer's disease as did ApoE4, and the smaller African-American series showed similar distribution of PS- 1 genotype between cases and controls.

TL;DR: The authors' APOE-stratified GWAS is the first to show GWS association for AD with SNPs in the chromosome 17q21.31 region, and the finding in the stage 1 sample that AD risk is significantly influenced by the interaction of APOE with TMEM106B (P=1·6 × 10−7) is noteworthy, because TMEM 106B variants have previously been associated with risk of frontotemporal dementia.

TL;DR: There is general consensus that APOE epsilon 4 is strongly associated with AD and that when present may represent an important risk factor for the disease, however, at the present time it is not recommended for use in routine clinical diagnosis nor should it be used for predictive testing.