A
Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
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Posted ContentDOI
MitoImpute: A Snakemake pipeline for imputation of mitochondrial genetic variants
Tim W McInerney,Brian Fulton-Howard,Christopher Patterson,Devashi Paliwal,Lars S. Jermiin,Hardip R. Patel,Judy Pa,Russell H. Swerdlow,Alison Goate,Simon Easteal,Shea J. Andrews +10 more
TL;DR: It is demonstrated that MitoImpute can be utilised by long-term studies whose older datasets have limited mtSNV genotypes, thus making them comparable with newer resequenced datasets.
Journal ArticleDOI
Comparison of amyloid burden in individuals with Down syndrome versus autosomal dominant Alzheimer's disease: a cross-sectional study
Anna H. Boerwinkle,Brian A. Gordon,Julie K. Wisch,Shaney Flores,Rachel L. Henson,Omar H. Butt,Nicole S. McKay,Charles Chen,Tammie L.S. Benzinger,Anne M. Fagan,Benjamin L. Handen,Bradley T. Christian,Elizabeth Ann Head,Mark Mapstone,Michael S. Rafii,Sid E. O'Bryant,Florence Lai,H. Diana Rosas,Joseph H. Lee,Wayne Silverman,Adam M. Brickman,Jasmeer P. Chhatwal,Carlos Cruchaga,R. Perrino,Chengjie Xiong,Jason Hassenstab,Eric McDade,Randall J. Bateman,Beau M. Ances,Howard J. Aizenstein,Howard Andrews,Karen L. Bell,Rasmus M. Birn,Peter Bulova,Amrita K. Cheema,Kewei Chen,Isabel C. H. Clare,Lorraine N. Clark,A. Chen,John N. Constantino,Eric Doran,Eleanor Feingold,Tatiana Foroud,Sigan L. Hartley,Christy Hom,Lawrence S. Honig,Milos D. Ikonomovic,Sterling C. Johnson,Courtney Patrice Jordan,M. Ilyas Kamboh,David Keator,William E. Klunk,Julia Kofler,William C. Kreisl,Sharon McHale,Patrick J. Lao,Charles M. Laymon,Ira T. Lott,Victoria Lupson,Chester A. Mathis,Davneet S. Minhas,Neelesh K. Nadkarni,Deborah Pang,Melissa E. Petersen,Julie C. Price,Margaret B. Pulsifer,Eric M. Reiman,Batool Rizvi,Marwan N. Sabbagh,Nicole Schupf,Dana L. Tudorascu,Rameshwari V. Tumuluru,Benjamin Tycko,Badri N. Varadarajan,Desirée A. White,Michael A. Yassa,Shahid Zaman,Faqi Zhang,Sara Adams,Ricardo F. Allegri,Akihiko Araki,Nicolas R. Barthélemy,Jacob A. Bechara,Sarah B. Berman,Courtney A. Bodge,S. Brandon,William Brooks,Jared R. Brosch,Jill Buck,Virginia Buckles,Kathleen Carter,Lisa Cash,Patricio Chrem Mendez,Jasmine Siew Lian Chua,Helena C. Chui,L. Gallen Courtney,Gregory S. Day,Chrismary DeLaCruz,Darcy R. Denner,Anna Diffenbacher,Aylin Dincer,Tamara Donahue,Jane Douglas,Duc Duong,Noelia Egido,Bianca Esposito,Martin R. Farlow,Becca Feldman,Colleen D. Fitzpatrick,Nick C. Fox,Erin E. Franklin,Nelly Joseph-Mathurin,Hisako Fujii,Samantha L. Gardener,Bernardino Ghetti,Alison Goate,Sarah Goldberg,Jill Goldman,Alyssa R. Gonzalez,Susanne Gräber-Sultan,Neill R. Graff-Radford,Morgan Graham,Julia D. Gray,Emily Gremminger,M. Grilo,Alexandrer Groves,Christian Haass,Lisa Häslerc,Cortaiga Hellm,Elizabeth M. Herries,Laura Hoechst-Swisher,Anna Hofmann,David M. Holtzman,Russ C. Hornbeck,Yakushev Igor,Ryoko Ihara,Takeshi Ikeuchi,Snezana Ikonomovic,Kenji Ishii,C. Jack,Gina Jerome,Erik C. B. Johnson,Mathias Jucker,Celeste M. Karch,Stephan A. Käser,Kensaku Kasuga,Sarah Keefe,W. Klunk,Robert A. Koeppe,Deborah Koudelis,Elke Kuder-Buletta,Christoph Laske,Allan I. Levey,Johannes Levin,Yan Li,Oscar L. Lopez,Jacob A. Marsh,Ralph Martins,Neal Mason,Colin L. Masters,Kwasi G. Mawuenyega,Austin A. McCullough,Arlene Mejia,Estrella Morenas-Rodríguez,John C. Morris,James M. Mountz,Catherine J. Mummery,Akem Nagamatsu,Katie Neimeyer,Yoshiki Niimi,James M. Noble,Joanne Norton,Brigitte Nuscher,U. Obermüller,Antoinette O'Connor,Riddhi Patira,Lingyan Ping,Oliver Preische,Alan E. Renton,John M. Ringman,Stephen Salloway,Peter R. Schofield,Michio Senda,Nicholas T. Seyfried,Kristine E. Shady,Hiroyuki Shimada,Wendy Sigurdson,Jennifer C. M. Smith,Lori A. Smith,Beth E. Snitz,Hamid R. Sohrabi,Sochenda Stephens,Kevin Taddei,Sarah Thompson,Jonathan Vöglein,Peter Wang,Qiang Wang,Elise A. Weamer,Jinbin Xu,Xiong Xu +199 more
Posted ContentDOI
Exome chip meta-analysis elucidates the genetic architecture of rare coding variants in smoking and drinking behavior
Dajiang J. Liu,David M. Brazel,Turcot,Xiaowei Zhan,Jian Gong,Daniel R. Barnes,Sarah Bertelsen,Yi Ling Chou,A. Mesut Erzurumluoglu,Jessica D. Faul,Jeff Haessler,Anke R. Hammerschlag,Chris Hsu,Manav Kapoor,Dongbing Lai,Nhung Le,Christiaan de Leeuw,Anu Loukola,Massimo Mangino,Carl A. Melbourne,Giorgio Pistis,Beenish Qaiser,Rebecca Rohde,Yaming Shao,Heather M. Stringham,Leah Wetherill,Wei Zhao,Arpana Agrawal,Laura J. Bierut,Chu Chen,Charles B. Eaton,Alison Goate,Christopher A. Haiman,Andrew C. Heath,William G. Iacono,Nicholas G. Martin,Tinca J. C. Polderman,Alex P. Reiner,John P. Rice,David Schlessinger,H. Steven Scholte,Jennifer A. Smith,Jean-Claude Tardif,Hilary A. Tindle,Andries R. van der Leij,Michael Boehnke,Jenny Chang-Claude,Francesco Cucca,Sean P. David,Tatiana Foroud,Sharon L.R. Kardia,Charles Kooperberg,Markku Laakso,Guillaume Lettre,Pamela A. F. Madden,Matt McGue,Kari E. North,Danielle Posthuma,Tim D. Spector,Daniel O. Stram,David R. Weir,Jaakko Kaprio,Gonçalo R. Abecasis,Scott I. Vrieze +63 more
TL;DR: The findings indicate that rare coding variants contribute to phenotypic variation, but that much larger samples and/or denser genotyping of rare variants will be required to successfully identify associations with these phenotypes, whether individual variants or gene‐ based associations.
Posted ContentDOI
Mendelian randomization indicates that TNF is not causally associated with Alzheimer\'s disease
Shea J. Andrews,Alison Goate +1 more
TL;DR: The results suggest that TNF-α antagonists are unlikely to reduce the risk of Alzheimer’s disease.
Journal ArticleDOI
A quantitative trait rare variant nonparametric linkage method with application to age-at-onset of Alzheimer's disease
Linhai Zhao,Zhihui Zhang,Zhihui Zhang,Sandra Rodriguez,Badri N. Vardarajan,Alan E. Renton,Alison Goate,Richard Mayeux,Gao T Wang,Gao T Wang,Suzanne M. Leal,Suzanne M. Leal +11 more
TL;DR: RV-QNPL provides a powerful resource to analyze QTs in families to elucidate their genetic etiology and is robust to population substructure and admixture, locus heterogeneity, and inclusion of nonpathogenic variants.