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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
Papers
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Journal ArticleDOI
Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline.
Jorge L. Del-Aguila,Maria Victoria Fernandez,Suzanne E. Schindler,Laura Ibanez,Yuetiva Deming,Shengmei Ma,Ben Saef,Kathleen Black,John P. Budde,Joanne Norton,Rachel Chasse,Alzheimer's Disease Neuroimaging Initiative,Oscar Harari,Alison Goate,Chengjie Xiong,John C. Morris,Carlos Cruchaga +16 more
TL;DR: The results indicate that the recently identified common and rare variants for AD susceptibility have a limited impact on the rate of dementia progression in AD patients.
Journal ArticleDOI
Dissection of the phenotypic and genotypic associations with nicotinic dependence
Li-Shiun Chen,Timothy B. Baker,Richard A. Grucza,Jen C. Wang,Eric O. Johnson,Naomi Breslau,Dorothy K. Hatsukami,Stevens S. Smith,Nancy L. Saccone,Scott F. Saccone,John P. Rice,Alison Goate,Laura J. Bierut +12 more
TL;DR: CPD is an important simple measure that captures in part the genetic associations of CHRNA5 and nicotine dependence, even when other more comprehensive measures of smoking behaviors are examined.
Journal ArticleDOI
GABRR1 and GABRR2, encoding the GABA-A receptor subunits ρ1 and ρ2, are associated with alcohol dependence
Xiaoling Xuei,Leah Flury-Wetherill,Danielle M. Dick,Alison Goate,Jay A. Tischfield,John I. Nurnberger,Marc A. Schuckit,John Kramer,Samuel Kuperman,Victor Hesselbrock,Bernice Porjesz,Tatiana Foroud,Howard J. Edenberg +12 more
TL;DR: Primary analysis using a median split for age of onset suggests that the association is strongest when the analysis is focused upon those with earlier onset of alcohol dependence.
Journal ArticleDOI
Association studies using novel polymorphisms in BACE1 and BACE2.
TL;DR: Genotyping a large cohort of AD cases and controls has shown no association between AD and the intronic polymorphism in BACE2 while there was a weak association between the BACE1 polymorphisms in exon 5 and AD in those carrying the APOE &epsis;4 allele.
Journal ArticleDOI
Parkinson disease is not associated with C9ORF72 repeat expansions.
Matthew B. Harms,Drexel A. Neumann,Bruno A. Benitez,Breanna Cooper,David Carrell,Brad A. Racette,Joel S. Perlmutter,Joel S. Perlmutter,Alison Goate,Carlos Cruchaga +9 more
TL;DR: Repeat-primed polymerase chain reaction was used to investigate the frequency of C9ORF72 repeat expansions in a cohort of patients with PD and control subjects, and no expansions were found among patients, suggesting that C9orF72 expansions are not a common cause of PD.