A
Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
Papers
More filters
Journal ArticleDOI
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families
Manav Kapoor,Jen Chyong Wang,Leah Wetherill,Nhung Le,Sarah Bertelsen,Anthony L. Hinrichs,John P. Budde,Arpana Agrawal,Laura Almasy,Kathleen K. Bucholz,Danielle M. Dick,Oscar Harari,Xuei Xiaoling,Victor Hesselbrock,John Kramer,John I. Nurnberger,John P. Rice,Marc A. Schuckit,Jay A. Tischfield,Bernice Porjesz,Howard J. Edenberg,Laura J. Bierut,Tatiana Foroud,Alison Goate +23 more
TL;DR: This extended family based genome-wide cox-proportional hazards analysis identified several loci that might be associated with age at onset of AD, including an intergenic SNP, rs2168784 on chromosome 3 that showed strong evidence of association among regular drinkers.
Journal ArticleDOI
Niemann–Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the β-secretase pathway
Martina Malnar,Marko Kosicek,Stefan Mitterreiter,Damir Omerbašić,Stefan F. Lichtenthaler,Alison Goate,Silva Hećimović +6 more
TL;DR: The results indicate that cholesterol may modulate APP processing indirectly by modulating APP expression at the cell surface and thus its cleavage by beta-secretase.
Journal ArticleDOI
Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits
Yuetiva Deming,Jian Xia,Jian Xia,Yefei Cai,Jenny Lord,Jenny Lord,Jorge L. Del-Aguila,Maria Victoria Fernandez,David Carrell,Kathleen Black,John P. Budde,Shengmei Ma,Benjamin Saef,Bill Howells,Sarah Bertelsen,Matthew H. Bailey,Perry G. Ridge,Holtzman David M,John C. Morris,Kelly R. Bales,Eve H. Pickering,Jin-Moo Lee,Laura Heitsch,John S. K. Kauwe,Alison Goate,Laura Piccio,Carlos Cruchaga +26 more
TL;DR: Three potential pleiotropic genes are found for plasma SELE and ACE levels, FUT2 for CA19-9 and CEA plasma levels, and APOE for ApoE and CRP levels, which suggest that these plasma protein levels may constitute informative endophenotypes for these complex traits.
Journal ArticleDOI
Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele.
Eileen N. Oni,Apoorva Halikere,Guohui Li,Alana J. Toro-Ramos,Mavis R. Swerdel,Jessica L. Verpeut,Jennifer C. Moore,Nicholas T. Bello,Laura J. Bierut,Alison Goate,Jay A. Tischfield,Zhiping P. Pang,Ronald P. Hart +12 more
TL;DR: Results show that N398 variant human DA neurons differentially express genes associated with ligand receptor interaction and synaptic function, and this study offers a proof-of-principle for utilizing human neurons to study gene variants contribution to addiction.
Journal ArticleDOI
Family-Based Association Analysis of Alcohol Dependence Criteria and Severity
Leah Wetherill,Manav Kapoor,Arpana Agrawal,Kathleen K. Bucholz,Daniel L. Koller,Sarah Bertelsen,Nhung Le,Jen-Chyong Wang,Laura Almasy,Victor Hesselbrock,John Kramer,John I. Nurnberger,Marc A. Schuckit,Jay A. Tischfield,Xiaoling Xuei,Bernice Porjesz,Howard J. Edenberg,Alison Goate,Tatiana Foroud +18 more
TL;DR: In this paper, the DSM-IV criteria for alcohol dependence were analyzed using latent class analysis (LCA) to identify classes defined by the pattern of endorsement of the criteria, and the strongest evidence of association was with SNPs in NALCN and OR51L1.