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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
Papers
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Journal ArticleDOI
Failure to replicate a protective effect of allele 2 of NACP/α‐synuclein polymorphism in Alzheimer's disease: An association study
TL;DR: No protective effect for NACP allele 2, or any of the other NACP alleles, was observed, in a comparable number of individuals diagnosed with dementia of the Alzheimer's type and in healthy, elderly controls.
Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression
Robert Culverhouse,Nancy L. Saccone,Amy C. Horton,Yinjiao Ma,Kaarin J. Anstey,Tobias Banaschewski,Margit Burmeister,Sarah Cohen-Woods,Bruno Etain,Helen L. Fisher,Noreen Goldman,Sébastien Guillaume,John Horwood,Gabriella Juhasz,Kathryn J. Lester,Laura Mandelli,Christel M. Middeldorp,Emilie Olié,Sandra Villafuerte,Tracy Air,Ricardo Araya,Lucy Bowes,Richard Burns,Enda M. Byrne,Carolyn Coffey,William L. Coventry,Katerina A.B. Gawronski,Dana A. Glei,Alex Hatzimanolis,Jouke-Jan Hottenga,Isabelle Jaussent,Catharine Jawahar,Christine Jennen-Steinmetz,John Kramer,Mohamed Lajnef,Keriann Little,Henriette E. Meyer zu Schwabedissen,Matthias Nauck,Esther Nederhof,Peter Petschner,Wouter J. Peyrot,Christian Schwahn,Grant C.B. Sinnamon,David Stacey,Yan Tian,Catherine Toben,Sandra Van der Auwera,Nick Wainwright,Jen-Chyong Wang,Gonneke Willemsen,Ian M. Anderson,Volker Arolt,Cecilia Åslund,Gyorgy Bagdy,Bernhard T. Baune,Frank Bellivier,Dorret I. Boomsma,Philippe Courtet,Udo Dannlowski,Eco J. C. de Geus,John Francis William Deakin,Simon Easteal,Thalia C. Eley,David M. Fergusson,Alison Goate,Xenia Gonda,Hans J. Grabe,Claudia Holzman,Eric O. Johnson,Martin A. Kennedy,Manfred Laucht,Nicholas G. Martin,Marcus R. Munafò,Kent W. Nilsson,Albertine J. Oldehinkel,Craig A. Olsson,Johan Ormel,Christian Otte,George C Patton,Brenda W.J.H. Penninx,Karen Ritchie,Marco Sarchiapone,J. M. Scheid,Alessandro Serretti,Johannes H. Smit,Nicholas C. Stefanis,Paul G. Surtees,Henry Völzke,Maxine Weinstein,Mary A. Whooley,John I. Nurnberger,Naomi Breslau,Laura J. Bierut +92 more
TL;DR: In this paper, the authors performed new analyses on 31 data sets containing 38,802 European ancestry subjects genotyped for 5-HTTLPR and assessed for depression and childhood maltreatment or other stressful life events, and meta-analysed the results.
Journal ArticleDOI
Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques.
Pranav Preman,Julia Tcw,Sara Calafate,An Snellinx,Maria Alfonso-Triguero,Nikky Corthout,Sebastian Munck,Dietmar Rudolf Thal,Alison Goate,Bart De Strooper,Bart De Strooper,Amaia M. Arranz +11 more
TL;DR: In this paper, a promising approach that consist of transplanting patient-derived and genetically modified astrocytes into the mouse brain to study human ASTs pathophysiology in the context of Alzheimer´s disease was described.
Patent
Mutant s182 genes
Alison Goate,John Hardy +1 more
TL;DR: In this paper, the S182 gene was used to identify mutations in genes homologous to S182, and a model system for Alzheimer's disease comprising a mutant S182 was proposed.
Journal ArticleDOI
SORL1 variants across Alzheimer’s disease European American cohorts
Maria Victoria Fernandez,Kathleen Black,David Carrell,Ben Saef,John P. Budde,Yuetiva Deming,Bill Howells,Jorge L. Del-Aguila,Shengmei Ma,Catherine Bi,Joanne Norton,Rachel Chasse,John C. Morris,Alison Goate,Carlos Cruchaga +14 more
TL;DR: This work examines the presence of rare coding variants in SORL1 in three different European American cohorts: early-onset, late-ONSet AD (LOAD) and familial LOAD.