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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
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Polygenic Risk Score of Sporadic Late Onset Alzheimer Disease Reveals a Shared Architecture with the Familial and Early Onset Forms
Jorge Del aguila,Benjamin Saef,Kathleen Black,Maria Victoria Fernandez,John P. Budde,Laura Ibanez,Manav Kapoor,Giuseppe Tosto,Richard Mayeux,David M. Holtzman,Anne M. Fagan,John C. Morris,Randall J. Bateman,Alison Goate,Carlos Cruchaga,Oscar Harari +15 more
TL;DR: The analysis confirms that the genetic factors identified for sLOAD also modulate risk in fLOAD and sEOAD cohorts and suggests that the burden of these risk variants is associated with familial clustering and earlier-onset of AD.
Posted ContentDOI
Upregulated GIRK2 counteracts ethanol-induced changes in excitability and respiration in human neurons
Iya Prytkova,Yiyuan Liu,Michael B. Fernando,Isabel Gameiro-Ros,Dina Popova,Chella Kamarajan,Xiaoling Xuei,David B. Chorlian,Howard J. Edenberg,Jay A. Tischfield,Bernice Porjesz,Zhiping P. Pang,Ronald P. Hart,Alison Goate,Paul A. Slesinger +14 more
TL;DR: In this article , the authors used CRISPRa induction and lentiviral expression to upregulate the GIRK2 protein, a subunit of a G-protein-coupled inwardly-rectifying potassium channel that regulates neuronal excitability.
Journal ArticleDOI
Discovery and validation of dominantly inherited Alzheimer’s disease mutations in populations from Latin America
Leonel T. Takada,Carmen Alaez-Verson,Bhagyashri D. Burgute,Ricardo Nitrini,Ana L. Sosa,Raphael Machado de Castilhos,Marcia Lorena Fagundes Chaves,E. Mariana Longoria,Karol Carrillo-Sánchez,S. Brucki,Luis Leonardo Flores-Lagunes,Carolina Molina,Marco Jiménez Olivares,Ellen Ziegemeier,Jennifer Petranek,Alison Goate,Carlos Cruchaga,Alan E. Renton,Maria Victoria Fernandez,Gregory S. Day,Eric McDade,Randall J. Bateman,Celeste M. Karch,Jorge J. Llibre-Guerra +23 more
TL;DR: In this paper , the authors used a systematic approach to assign the likelihood of pathogenicity in variants from densely affected families in Latin American populations, and identified five novel variants in the presenilin1 (PSEN1) gene from Brazilian and Mexican families.
Journal ArticleDOI
P1-331: Familiality and linkage analysis of behavioral symptoms and age at disease onset in late-onset Alzheimer’s disease
Paul Hollingworth,Marian L. Hamshere,Peter Holmans,Lesley Jones,Michael O'Donavan,Amanda J. Myers,John Hardy,Alison Goate,Simon Lovestone,Michael John Owen,Julie Williams +10 more
Journal Article
Substantial linkage disequilibrium across the insulin degrading enzyme locus but no association with late-onset Alzheimer's disease
Lesley Jones,Richard Abraham,Amanda J. Myers,Fabienne Wavrant DeVrieze,M. Hamshere,H. M. Thomas,Helen Marshall,Danielle Compton,Gillian Spurlock,D. Turic,B. Hoogendorn,Jennifer M. Kwon,R. C. Petersen,E. Tanaglos,Joanne Norton,John C. Morris,R. Bullock,D Liolitsa,Simon Lovestone,John Hardy,Alison Goate,Michael Conlon O'Donovan,Julie Williams,Michael John Owen +23 more