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Alison Goate
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 781
Citations - 98332
Alison Goate is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Genome-wide association study & Alzheimer's disease. The author has an hindex of 136, co-authored 721 publications receiving 85846 citations. Previous affiliations of Alison Goate include St Mary's Hospital & Brown University.
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Journal ArticleDOI
Differential susceptibility to adolescent externalizing trajectories: examining the interplay between CHRM2 and peer group antisocial behavior.
Shawn J. Latendresse,John E. Bates,Jackson A. Goodnight,Jennifer E. Lansford,John P. Budde,Alison Goate,Kenneth A. Dodge,Gregory S. Pettit,Danielle M. Dick +8 more
TL;DR: Findings indicate that relative to a normative "lower risk" externalizing trajectory, likelihood of membership in two "higher risk" trajectories increased with each additional copy of the minor allelic variant at CHRM2, and that this association was exacerbated among those exposed to higher levels of peer group antisocial behavior.
Journal ArticleDOI
Shared genetic contribution to ischemic stroke and Alzheimer's disease
Matthew Traylor,Matthew Traylor,Poneh Adib-Samii,Denise Harold,Martin Dichgans,Julie Williams,Cathryn M. Lewis,Hugh S. Markus,Myriam Fornage,Elizabeth G. Holliday,Pankaj Sharma,Joshua C. Bis,Bruce M. Psaty,Sudha Seshadri,Mike A. Nalls,William J. Devan,Giorgio B. Boncoraglio,Rainer Malik,Braxton D. Mitchell,Steven J. Kittner,M. Arfan Ikram,Robert Clarke,Jonathan Rosand,James F. Meschia,Cathie Sudlow,Peter M. Rothwell,Christopher R Levi,Steve Bevan,Laura L. Kilarski,Matthew Walters,Vincent Thijs,Agnieszka Slowik,Arne Lindgren,Paul I.W. de Bakker,Jean-Charles Lambert,Carla A. Ibrahim-Verbaas,Adam C. Naj,Rebecca Sims,Céline Bellenguez,Gyungah Jun,Anita L. DeStefano,Gary W. Beecham,Benjamin Grenier-Boley,Giancarlo Russo,Tricia A. Thornton-Wells,Nicola Jones,Albert V. Smith,Vincent Chouraki,Charlene Thomas,Diana Zelenika,Badri N. Vardarajan,Yoichiro Kamatani,Chiao-Feng Lin,Amy Gerrish,Helena Schmidt,Brian W. Kunkle,Melanie L. Dunstan,Agustín Ruiz,Marie Thçrèse Bihoreau,Seung Hoan Choi,Christiane Reitz,Florence Pasquier,Paul Hollingworth,Alfredo Ramirez,Olivier Hanon,Annette L. Fitzpatrick,Joseph D. Buxbaum,Dominique Campion,Paul K. Crane,Clinton T. Baldwin,Tim Becker,Vilmundur Gudnason,Carlos Cruchaga,David Craig,Najaf Amin,Claudine Berr,Oscar L. Lopez,Philip L. De Jager,Vincent Deramecourt,Janet A. Johnston,Denis A. Evans,Simon Lovestone,Luc Letenneur,Francisco J. Morón,David C. Rubinsztein,Gudny Eiriksdottir,Kristel Sleegers,Alison Goate,Nathalie Fiçvet,Matthew J. Huentelman,Michael Gill,Kristelle Brown,M. Ilyas Kamboh,Lina Keller,Pascale Barberger-Gateau,Bernadette McGuinness,Eric B. Larson,Robert C. Green,Amanda J. Myers,Carole Dufouil,Stephen Todd,David Wallon,Seth Love,Ekaterina Rogaeva,John Gallacher,Peter St George-Hyslop,Jordi Clarimón,Alberto Lleó,Anthony Bayer,Debby W. Tsuang,Lei Yu,Magda Tsolaki,Paola Bossù,Gianfranco Spalletta,Petroula Proitsi,John Collinge,Sandro Sorbi,Florentino Sanchez-Garcia,Nick C. Fox,John Hardy,Maria Candida Deniz Naranjo,Paolo Bosco,Carol Brayne,Daniela Galimberti,Michelangelo Mancuso,Fiona E. Matthews,Susanne Moebus,Patrizia Mecocci,Maria Del Zompo,Wolfgang Maier,Harald Hampel,Alberto Pilotto,María J. Bullido,Francesco Panza,Paolo Caffarra,Benedetta Nacmias,John R. Gilbert,Manuel Mayhaus,Lars Lannfelt,Hakon Hakonarson,Sabrina Pichler,Minerva M. Carrasquillo,Martin Ingelsson,Duane Beekly,Victoria Alvarez,Fanggeng Zou,Otto Valladares,Steven G. Younkin,Eliecer Coto,Kara L. Hamilton-Nelson,Wei Gu,Cristina Razquin,Pau Pastor,Ignacio Mateo,Michael John Owen,Kelley Faber,Palmi V. Jonsson,Onofre Combarros,Michael Conlon O'Donovan,Laura B. Cantwell,Hilkka Soininen,Deborah Blacker,Simon Mead,Thomas H. Mosley,David A. Bennett,Tamara B. Harris,Laura Fratiglioni,Clive Holmes,Renée F.A.G. de Bruijn,Peter Passmore,Thomas J. Montine,Karolien Bettens,Jerome I. Rotter,Alexis Brice,Kevin Morgan,Tatiana Foroud,Walter A. Kukull,Didier Hannequin,John Powell,Michael A. Nalls,Karen Ritchie,Kathryn L. Lunetta,John S. K. Kauwe,Eric Boerwinkle,Matthias Riemenschneider,Mercè Boada,Mikko Hiltunen,Eden R. Martin,Reinhold E. Schmidt,Dan Rujescu,Li-San Wang,Jean-François Dartigues,Richard Mayeux,Christophe Tzourio,Albert Hofman,Markus M. Nöthen,Caroline Graff,Lesley Jones,Jonathan L. Haines,Peter Holmans,Mark Lathrop,Margaret A. Pericak-Vance,Lenore J. Launer,Lindsay A. Farrer,Cornelia M. van Duijn,Christine Van Broeckhoven,Valentina Moskvina,Gerard D. Schellenberg,Philippe Amouyel +208 more
TL;DR: In this article, the authors investigated the evidence that shared genetic factors underpin the two diseases and found evidence of a shared genetic contribution between Alzheimer's disease and small vessel stroke (rG [standard error] 0.37 [0.17] and p 0.011).
Journal ArticleDOI
Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response.
Anna A. Pimenova,Manon Herbinet,Ishaan Gupta,Saima Machlovi,Kathryn R. Bowles,Edoardo Marcora,Alison Goate +6 more
TL;DR: Several microglial responses that are modulated byPU.1 expression levels are identified and proposed that risk association of PU.1 to AD is driven by increased pro-inflammatory response due to increased viability of cells under cytotoxic conditions, which supports the protective effect of SPI1 genotype in AD.
Journal ArticleDOI
SNP analysis to dissect human traits.
TL;DR: The use of 'reduced representation shotgun' methods for more efficient detection of single nucleotide polymorphisms (SNPs), the employment of high-throughput genotyping techniques, the development of SNP maps that incorporate information about linkage disequilibrium, and the use of SNPs in identifying susceptibility genes for common illnesses are proposed.
Journal ArticleDOI
A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin
Yuetiva Deming,Jian Xia,Yefei Cai,Jenny Lord,Peter Holmans,Sarah Bertelsen,Holtzman David M,John C. Morris,Kelly R. Bales,Eve H. Pickering,John S. K. Kauwe,Alison Goate,Carlos Cruchaga +12 more
TL;DR: Gene ontology analyses suggest that CSF CLU levels may be associated with wound healing and immune response which supports previous functional studies that demonstrated an association between CLU and IL6.