Hong Liu

TL;DR: This study is the first to comprehensively demonstrate the associations of irAEs and antibiotic during anti-PD-1/PD-L1 therapy across a wide spectrum of cancers by analyzing multisource data.

TL;DR: The results presented in this paper suggest that the inherent genetic strategies, together with frequent gene importing from many organisms (HGT) have contributed to the evolution of modular PKSs in Sorangium.

Abstract: Dense Li/Ta-codoped KNN-based piezoceramics with d(33)* up to 375 pm/V were successfully fabricated by conventional sintering at a temperature as low as 900 degrees C by using LiF as a sintering additive. The reduction of densification temperature up to 200 degrees C was realized by a transient liquid phase sintering mechanism, consequently no grain boundary phase was observed in the sintered samples. It was found that the addition of LiF could further shift down the tetragonal orthorhombic transition point (TT-O), indicating that a small amount of Li+ could diffuse into the A-site of KNN matrix. The introduction of LiF enhanced the linearity of strain curves of the ceramics, which is unambiguously in favor for the actuator application. The present work reveals that low-temperature sintered LiF-doped KNN-based piezoceramics demonstrates promising potential in multilayer-structured actuator applications. (C) 2013 Elsevier Ltd. All rights reserved.

TL;DR: This study exemplifies the importance of the integrative use of computational methods and experimental techniques in drug discovery by identifying a covalent FGFR inhibitor 15, which showed a highly selective and potent FGFR inhibition profile.

TL;DR: In this paper, the commercially available CuO powder is demonstrated to be a robust catalyst for hydrogenation of nitroarenes using ammonia borane as a hydrogen source under mild conditions.