Bruce M. Psaty

TL;DR: Until the results of large long-term clinical trials evaluating the effects of calcium channel blockers and ACE inhibitors on cardiovascular disease incidence are completed, the available scientific evidence provides strong support for the current national guidelines, which recommend diuretics and beta-blockers as firstline agents and low-dose therapy for all antihypertensive agents.

TL;DR: Current drinkers of alcohol in high-income countries, the threshold for lowest risk of all-cause mortality was about 100 g/week, and data support limits for alcohol consumption that are lower than those recommended in most current guidelines.

TL;DR: In this paper, the authors combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci associated with general cognitive function.

TL;DR: The risk of primary cardiac arrest among patients receiving combined thiazide anesthetic drugs for hypertension among enrollees of a health maintenance organization is higher than expected.

TL;DR: It is concluded that factor V Leiden increases the risk of MI in young women, and this effect seems to be confined largely to current smokers.