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Phillip A. Sharp
Researcher at Massachusetts Institute of Technology
Publications - 618
Citations - 125567
Phillip A. Sharp is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 172, co-authored 614 publications receiving 117126 citations. Previous affiliations of Phillip A. Sharp include McGovern Institute for Brain Research & Medical Research Council.
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Journal ArticleDOI
Dynamic association of proteins with the pre-mRNA branch region.
Andrew M. MacMillan,Charles C. Query,Charles R. Allerson,Swaine L. Chen,Gregory L. Verdine,Phillip A. Sharp +5 more
TL;DR: It is established that the branch region is recognized in a dynamic fashion by multiple distinct proteins during the course of spliceosomal assembly.
Journal ArticleDOI
Viral DNA Sequences in Cells Transformed by Simian Virus 40, Adenovirus Type 2 and Adenovirus Type 5
Joseph Sambrook,Michael R. Botchan,P.H. Gallimore,Brad Ozanne,Ulf Pettersson,James C. Williams,Phillip A. Sharp +6 more
TL;DR: The anastomosis of various features has worked out well: it has resulted in a groundplan on which the apparently diverse elevations of a fast-growing field can quickly be sited with respect to one another.
Journal ArticleDOI
TFEB has DNA- binding and oligomerization properties of a unique helix- loop- helix/ leucine zipper family.
TL;DR: Analysis of basic domain residues in this family of proteins revealed a pattern of sequence conservation predictive of an interacting alpha-helical face, which suggests the b-HLH-LZ domain structure to define a distinct family of DNA-binding factors.
c-Myc regulates transcriptional pause release
Peter B. Rahl,Charles Y. Lin,Amy C. Seila,Ryan A. Flynn,Scott McCuine,Christopher B. Burge,Phillip A. Sharp,Richard A. Young +7 more
TL;DR: In this article, it was shown that the transcription factor c-Myc plays a major role in Pol II pause release rather than recruitment at its target genes, which suggests that some transcription factors recruit the transcription apparatus to promoters, whereas others effect promoter-proximal pause release.
PatentDOI
Tat-sf: cofactor for stimulation of transcriptional elongation by hiv-1 tat
Phillip A. Sharp,Qiang Zhou +1 more
TL;DR: The Tat-Stimulatory factor is involved in the regulation of transcriptional elongation of HIV-1 by Tat as mentioned in this paper, which is a transcriptional activity factor, as well as genes encoding this factor and fragments and biologically functional variants thereof.