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Phillip A. Sharp
Researcher at Massachusetts Institute of Technology
Publications - 618
Citations - 125567
Phillip A. Sharp is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 172, co-authored 614 publications receiving 117126 citations. Previous affiliations of Phillip A. Sharp include McGovern Institute for Brain Research & Medical Research Council.
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Journal ArticleDOI
Tumour necrosis factor alpha regulates iron transport and transporter expression in human intestinal epithelial cells.
Deborah M. Johnson,Deborah M. Johnson,Henry K. Bayele,Kelly L Johnston,Kelly L Johnston,J. P. Tennant,J. P. Tennant,Surjit K. S. Srai,Phillip A. Sharp,Phillip A. Sharp +9 more
TL;DR: The data suggest that TNFα could regulate dietary iron absorption and that the apical transport machinery is the target for these actions.
Journal ArticleDOI
Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR–mediated direct in vivo screening
Guangchuan Wang,Ryan D. Chow,Lupeng Ye,Christopher D. Guzman,Xiaoyun Dai,Matthew B. Dong,Feng Zhang,Phillip A. Sharp,Randall Jeffrey Platt,Randall Jeffrey Platt,Sidi Chen +10 more
TL;DR: AAV-mediated autochthonous CRISPR screens provide a powerful means for mapping a provisional functional cancer genome atlas of tumor suppressors in vivo, revealing the functional consequence of multiple variants in driving liver tumorigenesis in immunocompetent mice.
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Electrophoretic separation of polyadenylation-specific complexes.
TL;DR: A polyadenylation-specific complex composed of precursor RNA containing the adenovirus-2 L3 site and HeLa cellular components was detected by electrophoresis on a native, low-percentage polyacrylamide gel and it was proposed that formation of this complex represents an intermediate step in polyadenolation.
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Improving wheat as a source of iron and zinc for global nutrition
Janneke Balk,Janneke Balk,James M. Connorton,James M. Connorton,Yongfang Wan,Alison Lovegrove,Katie L. Moore,Cristobal Uauy,Phillip A. Sharp,Peter R. Shewry +9 more
TL;DR: In this article, the authors used transgenic strategies to increase the contents of iron and zinc in white flour, by converting the starchy endosperm tissue into a sink for minerals.
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Curcumin and (-)- Epigallocatechin-3-Gallate Protect Murine MIN6 Pancreatic Beta-Cells Against Iron Toxicity and Erastin-Induced Ferroptosis.
TL;DR: The data identify curcumin and EGCG as novel ferroptosis inhibitors, which might exert their protective effects by acting as iron chelators and preventing GSH depletion, GPX4 inactivation, and lipid peroxidation in MIN6 cells.