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Phillip A. Sharp
Researcher at Massachusetts Institute of Technology
Publications - 618
Citations - 125567
Phillip A. Sharp is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 172, co-authored 614 publications receiving 117126 citations. Previous affiliations of Phillip A. Sharp include McGovern Institute for Brain Research & Medical Research Council.
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Characterization of the branch site in lariat RNAs produced by splicing of mRNA precursors
TL;DR: The branch site of lariat RNAs produced during the splicing of the first two late leader exons of adenovirus-2 has a structure of …A2′p5′G…3′ p5′U….
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Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens.
TL;DR: The results suggest that the SV40 large T antigen is not an acute transforming gene like the polyomavirus middle T antigen but is similar to the establishment genes such as myc and adenovirus EIa.
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Transcription-coupled and DNA damage-dependent ubiquitination of RNA polymerase II in vitro
TL;DR: A correlation between ubiquitination of RNA Pol II and arrest of transcription in vitro is demonstrated and it is proposed that components of the reaction recognize elongating Pol II–DNA complexes arrested by α-amanitin or cisplatin lesions, triggering Ubiquitination.
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Expression of early adenovirus genes requires a viral encoded acidic polypeptide
TL;DR: Host-range mutants of adenovirus 5 that contain a defect in region E1A fail to replicate in HeLa cells and to transform rodent cells, and results strongly imply that the Mr 51,000 polypeptide is needed to regulate expression of adjacent viral genes during the early phase of adanovirus infection.