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Phillip A. Sharp
Researcher at Massachusetts Institute of Technology
Publications - 618
Citations - 125567
Phillip A. Sharp is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 172, co-authored 614 publications receiving 117126 citations. Previous affiliations of Phillip A. Sharp include McGovern Institute for Brain Research & Medical Research Council.
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Journal ArticleDOI
A triple helix stabilizes the 3′ ends of long noncoding RNAs that lack poly(A) tails
Jeremy E. Wilusz,Courtney K. JnBaptiste,Laura Lu,Claus-D. Kuhn,Leemor Joshua-Tor,Leemor Joshua-Tor,Phillip A. Sharp +6 more
TL;DR: It is found that a transcript ending in a triple helix is efficiently repressed by microRNAs in vivo, arguing against a major role for the poly(A) tail in microRNA-mediated silencing and suggest that RNA triple-helical structures likely have key regulatory functions in vivo.
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A Circuitous Route to Noncoding RNA
TL;DR: In this paper, the authors show that less than 2% of the human genome actually codes for proteins, prompting a search for functions for the other 98% genome, once considered to be mostly “junk DNA.”
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Poly(ADP-Ribose) Regulates Stress Responses and MicroRNA Activity in the Cytoplasm
TL;DR: It is concluded that poly(ADP-ribose) is a key regulator of posttranscriptional gene expression in the cytoplasm, which accumulate RNA-binding proteins that regulate the translation and stability of mRNAs upon stress.
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Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli: I. Structure of F-prime factors
TL;DR: The sequence relations between some bacterial F-prime factors in Escherichia coli have been determined by observing the pattern of duplex and single-stranded regions in heteroduplexes consisting of one strand from one episome and the complementary strand from another.
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Promoter directionality is controlled by U1 snRNP and polyadenylation signals
TL;DR: In this paper, the authors show that asymmetric sequence determinants flanking gene transcription start sites control promoter directionality by regulating promoter-proximal cleavage and polyadenylation.