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Phillip A. Sharp
Researcher at Massachusetts Institute of Technology
Publications - 618
Citations - 125567
Phillip A. Sharp is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 172, co-authored 614 publications receiving 117126 citations. Previous affiliations of Phillip A. Sharp include McGovern Institute for Brain Research & Medical Research Council.
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Journal ArticleDOI
The octamer binding transcription factor Oct-1 is a stress sensor
TL;DR: Results indicate that Oct-1 modulates the activity of genes important for the cellular response to stress, including many associated with oxidative and metabolic stress.
Journal ArticleDOI
The molecular basis of copper and iron interactions.
TL;DR: There is emerging evidence that a number of other components of the intestinal Fe transport pathway are also Cu sensitive, suggesting that the Fe–Cu relationship may be more complex than first thought.
Journal ArticleDOI
The usefulness of in vitro models to predict the bioavailability of iron and zinc: A consensus statement from the HarvestPlus expert consultation
Susan J. Fairweather-Tait,Sean Lynch,Christine Hotz,Richard F. Hurrell,Leo Abrahamse,Steve Beebe,Stine B. Bering,K. Bukhave,Ray Glahn,Michael Hambidge,Janet R. Hunt,Bo Lönnerdal,Denis R. Miller,Najat Mohktar,Penelope Nestel,Manju B. Reddy,Ann-Sofie Sandberg,Phillip A. Sharp,Birgit Teucher,Trinidad P. Trinidad +19 more
TL;DR: While in vitro methods can be used to generate ideas and develop hypotheses, they cannot be used alone for important decisions concerning food fortification policy, selection of varieties for plant breeding programs, or for new product development in the food industry.
Journal ArticleDOI
The cellular C1 factor of the herpes simplex virus enhancer complex is a family of polypeptides.
Thomas M. Kristie,Joel L. Pomerantz,Joel L. Pomerantz,Teresa C. Twomey,Stephen A. Parent,Phillip A. Sharp +5 more
TL;DR: The α/immediate early genes of herpes simplex virus are regulated by the specific assembly of a multiprotein enhancer complex containing the Oct-1 POU domain protein, the viral α-transinduction factor αTIF, (VP16, ICP25), and the C1 cellular factor.