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Phillip A. Sharp
Researcher at Massachusetts Institute of Technology
Publications - 618
Citations - 125567
Phillip A. Sharp is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 172, co-authored 614 publications receiving 117126 citations. Previous affiliations of Phillip A. Sharp include McGovern Institute for Brain Research & Medical Research Council.
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Regulation of in vitro and in vivo transcription of early-region IV of adenovirus type 5 by multiple cis-acting elements.
TL;DR: The data indicate that multiple cis-acting elements are required for efficient transcription from the EIV promoter in both in vitro and in vivo systems.
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RNA sequence analysis defines Dicer's role in mouse embryonic stem cells (Proceedings of the National Academy of Science of the United States of America (November 13, 2007) 104, 46, (18097-18102) DOI: 10.1073/pnas.0709193104)
Journal ArticleDOI
Construction, stable transformation, and function of an amber suppressor tRNA gene in Drosophila melanogaster
TL;DR: Strains derived from the two female-fertile integration events were shown to have a low level of amber-suppressing activity by their ability to suppress an amber mutation in a chloramphenicol acetyltransferase gene.
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Evolution of weak cooperative interactions for biological specificity.
Ang Gao,Krishna Shrinivas,Paul Lepeudry,Hiroshi I. Suzuki,Phillip A. Sharp,Arup K. Chakraborty,Arup K. Chakraborty +6 more
TL;DR: It is argued that the emergence of weak cooperative interactions for mediating specificity makes the system more capable of undergoing evolutionary changes robustly, and thus this mechanism has been repeatedly positively selected in increasingly complex organisms.