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Phillip A. Sharp
Researcher at Massachusetts Institute of Technology
Publications - 618
Citations - 125567
Phillip A. Sharp is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: RNA & Gene. The author has an hindex of 172, co-authored 614 publications receiving 117126 citations. Previous affiliations of Phillip A. Sharp include McGovern Institute for Brain Research & Medical Research Council.
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Genome-wide identification of Ago2 binding sites from mouse embryonic stem cells with and without mature microRNAs
Anthony K.L. Leung,Amanda G. Young,Amanda G. Young,Arjun Bhutkar,Grace X.Y. Zheng,Grace X.Y. Zheng,Andrew D. Bosson,Cydney B. Nielsen,Cydney B. Nielsen,Phillip A. Sharp +9 more
TL;DR: In this paper, photo-cross-linking immunoprecipitation using antibodies to Argonaute (Ago2) followed by deep sequencing of RNAs (CLIP-seq) was performed to identify endogenous miRNA binding sites in mouse embryonic stem cells.
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Meeting Global Challenges
Phillip A. Sharp,Alan I. Leshner +1 more
TL;DR: Every major challenge of modern life, such as ensuring energy, health, water, or food security in a sustainable world with a predicted nine billion inhabitants, has complex science and technology components and is global in character.
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TATA-binding protein and associated factors in polymerase II and polymerase III transcription.
R E Meyers,Phillip A. Sharp +1 more
TL;DR: In this paper, the TBP-TAF subcomponent of TFIIIB was found to be active in reconstitution of pol II transcription, while TBP alone cannot complement pol III transcription reactions.
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Enhancing mineral bioavailability from cereals: Current strategies and future perspectives
TL;DR: The potential use of aleurone as a bioavailable source of minerals that could be added to wheat‐based foods is investigated, which has relevance for the food industry and may establish the use of AleuroneAs a functional food ingredient for fortification of a range of cereal‐based food products.
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Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons
Amanda J. Whipple,Amanda J. Whipple,Vincent Breton-Provencher,Hannah N. Jacobs,Udbhav K. Chitta,Mriganka Sur,Phillip A. Sharp +6 more
TL;DR: It is shown that maternally expressed miRNAs from the miR-379/410 cluster direct the RNA-induced silencing complex (RISC) to transcriptional and developmental regulators, including paternally expression transcripts like Plagl1.