Phillip A. Sharp

TL;DR: In this article, the authors provided methods for treating or decreasing the likelihood of developing a stress-granule related disorder and/or cancer by administering one or more poly-ADP-ribose polymerase (PARP) inhibitors, one OR more PARP activators, one Or-More PARP inhibitors, poly-AdP-Ribose glycosylases (PARG) activators and poly-ARH3 activators.

TL;DR: An unrecognized role for CD44 in oncogenic Kras-induced lung adenocarcinoma is revealed and it is suggested that targeting CD44 could be an effective strategy for haltingKras-dependent carcinomas.

TL;DR: The purpose of this study was to assess the iron transport capacity of the rat proximal colon and to determine whether iron absorption is regulated by changes in dietary iron content.

TL;DR: Results of mobility-shift DNA-binding assays and methylation interference experiments showed that undifferentiated F9 cells contained a factor(s) that bound to a sequence within the 5' and central part of the ICS, termed the MHC negative regulatory element (NRE), which coincided with the site of mutations that increased promoter activity in F8 cells and was distinct from the element to which interferon-response factors bind.

TL;DR: Kinetic studies suggest that the 50S complex is an intermediate in the polyadenylation reaction and forms at an early stage in the reaction and at later times contains both poly(A)+ RNA as well as unreacted precursor.