R
Roberto Romero
Researcher at National Institutes of Health
Publications - 1622
Citations - 121818
Roberto Romero is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Amniotic fluid & Pregnancy. The author has an hindex of 151, co-authored 1516 publications receiving 108321 citations. Previous affiliations of Roberto Romero include University of Michigan & Weizmann Institute of Science.
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Journal ArticleDOI
A Role for the Inflammasome in Spontaneous Labor at Term.
Roberto Romero,Yi Xu,Yi Xu,Olesya Plazyo,Olesya Plazyo,Piya Chaemsaithong,Piya Chaemsaithong,Tinnakorn Chaiworapongsa,Tinnakorn Chaiworapongsa,Ronald Unkel,Ronald Unkel,Nandor Gabor Than,Po Jen Chiang,Zhong Dong,Zhong Dong,Zhonghui Xu,Zhonghui Xu,Adi L. Tarca,Adi L. Tarca,Vikki M. Abrahams,Sonia S. Hassan,Sonia S. Hassan,Lami Yeo,Lami Yeo,Nardhy Gomez-Lopez,Nardhy Gomez-Lopez +25 more
TL;DR: The aims of this study were to determine the expression of major inflammasome components in the chorioamniotic membranes in spontaneous labor at term and whether these events are associated with the release of the mature forms of IL‐1β and IL‐18.
Journal ArticleDOI
Expression patterns of microRNAs in the chorioamniotic membranes: a role for microRNAs in human pregnancy and parturition
Daniel Montenegro,Roberto Romero,Roberto Romero,Sung Su Kim,Adi L. Tarca,Adi L. Tarca,Sorin Draghici,Juan Pedro Kusanovic,Jung Sun Kim,Jung Sun Kim,Deug-Chan Lee,Offer Erez,Francesca Gotsch,Sonia S. Hassan,Sonia S. Hassan,Chong Jai Kim,Chong Jai Kim +16 more
TL;DR: The novel findings reported herein strongly suggest that post‐transcriptional regulation of genes by miRNAs, coupled with the changes of miRNA processing machinery in the chorioamniotic membranes, plays a role in pregnancy and parturition.
Journal ArticleDOI
Effector and Activated T Cells Induce Preterm Labor and Birth That Is Prevented by Treatment with Progesterone.
Marcia Arenas-Hernandez,Marcia Arenas-Hernandez,Marcia Arenas-Hernandez,Roberto Romero,Yi Xu,Yi Xu,Bogdan Panaitescu,Bogdan Panaitescu,Valeria Garcia-Flores,Valeria Garcia-Flores,Derek Miller,Derek Miller,Hyunyoung Ahn,Bogdan Done,Bogdan Done,Sonia S. Hassan,Sonia S. Hassan,Chaur-Dong Hsu,Adi L. Tarca,Adi L. Tarca,Adi L. Tarca,Carmen Sánchez-Torres,Nardhy Gomez-Lopez,Nardhy Gomez-Lopez +23 more
TL;DR: Findings provide mechanistic evidence showing that effector and activated T cells cause pathological inflammation at the maternal-fetal interface, in the mother, and in the fetus, inducing preterm labor and birth and adverse neonatal outcomes.
Journal ArticleDOI
Clinical chorioamnionitis is characterized by changes in the expression of the alarmin HMGB1 and one of its receptors, sRAGE
Roberto Romero,Tinnakorn Chaiworapongsa,Zeynep Alpay Savasan,Youssef Hussein,Zhong Dong,Juan Pedro Kusanovic,Chong Jai Kim,Sonia S. Hassan +7 more
TL;DR: This finding provides evidence that an alarmin, HMGB1, and one of its receptors, sRAGE, are engaged in the process of clinical chorioamnionitis at term, quite different from those observed in cases of intra-amniotic infection/ inflammation in preterm gestations.
Journal ArticleDOI
Fetal cleft lip and palate detection by three-dimensional ultrasonography.
TL;DR: A standardized approach for the evaluation of cleft lip and palate by three‐dimensional (3D) ultrasonography is demonstrated to demonstrate a standardized approach.