Institution
Autonomous University of Barcelona
Education•Cerdanyola del Vallès, Spain•
About: Autonomous University of Barcelona is a education organization based out in Cerdanyola del Vallès, Spain. It is known for research contribution in the topics: Population & Context (language use). The organization has 37833 authors who have published 80514 publications receiving 2321142 citations. The organization is also known as: Universitat Autònoma de Barcelona & Computer Vision Center.
Topics: Population, Context (language use), Medicine, Cancer, Transplantation
Papers published on a yearly basis
Papers
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TL;DR: The nu p process as mentioned in this paper is a nucleosynthesis process that occurs in supernovae (and possibly gamma-ray bursts) when strong neutrino fluxes create proton-rich ejecta.
Abstract: We present a new nucleosynthesis process that we denote as the nu p process, which occurs in supernovae (and possibly gamma-ray bursts) when strong neutrino fluxes create proton-rich ejecta. In this process, antineutrino absorptions in the proton-rich environment produce neutrons that are immediately captured by neutron-deficient nuclei. This allows for the nucleosynthesis of nuclei with mass numbers A>64, , making this process a possible candidate to explain the origin of the solar abundances of (92,94)Mo and (96,98)Ru. This process also offers a natural explanation for the large abundance of Sr seen in a hyper-metal-poor star.
441 citations
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Soochow University (Suzhou)1, Stanford University2, Polytechnic University of Milan3, University of California, Santa Barbara4, University of California, Los Angeles5, University of Modena and Reggio Emilia6, University of Massachusetts Amherst7, Katholieke Universiteit Leuven8, Peking University9, University College London10, National Chiao Tung University11, University of Texas at Austin12, IBM13, University of Granada14, Autonomous University of Barcelona15, Singapore University of Technology and Design16, East China Normal University17, University of Michigan18, Liverpool John Moores University19, Tsinghua University20, Chinese Academy of Sciences21, Technische Universität München22, RWTH Aachen University23
TL;DR: This manuscript describes the most recommendable methodologies for the fabrication, characterization, and simulation of RS devices, as well as the proper methods to display the data obtained.
Abstract: Resistive switching (RS) is an interesting property shown by some materials systems that, especially during the last decade, has gained a lot of interest for the fabrication of electronic devices, with electronic nonvolatile memories being those that have received the most attention. The presence and quality of the RS phenomenon in a materials system can be studied using different prototype cells, performing different experiments, displaying different figures of merit, and developing different computational analyses. Therefore, the real usefulness and impact of the findings presented in each study for the RS technology will be also different. This manuscript describes the most recommendable methodologies for the fabrication, characterization, and simulation of RS devices, as well as the proper methods to display the data obtained. The idea is to help the scientific community to evaluate the real usefulness and impact of an RS study for the development of RS technology. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
441 citations
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National Taiwan University1, Sungkyunkwan University2, Seoul National University3, Emory University4, Harvard University5, National Cheng Kung University6, University of Ulsan7, Institut Gustave Roussy8, Autonomous University of Barcelona9, University of Manchester10, Carolinas Healthcare System11, University of Turin12, University of California, San Diego13, AstraZeneca14
TL;DR: In patients with EGFRm T790M advanced NSCLC who progress after EGFR-TKI treatment, osimertinib provides a high ORR, encouraging PFS, and durable response, and this article reports the results from the phase II extension component.
Abstract: Purpose Osimertinib is an irreversible epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) selective for both EGFR-TKI sensitizing ( EGFRm) and T790M resistance mutations. AURA (NCT01802632) is a phase I/II clinical trial to determine the dose, safety, and efficacy of osimertinib. This article reports the results from the phase II extension component. Patients and Methods Patients with EGFR-TKI-pretreated EGFRm- and T790M-positive advanced non-small-cell lung cancer (NSCLC) received once-daily osimertinib 80 mg. T790M status was confirmed by central testing from a tumor sample taken after the most recent disease progression. Patients with asymptomatic, stable CNS metastases that did not require corticosteroids were allowed to enroll. The primary end point was objective response rate (ORR) by independent radiology assessment. Secondary end points were disease control rate, duration of response, progression-free survival (PFS), and safety. Patient-reported outcomes comprised an exploratory objective. Results In total, 201 patients received treatment, with a median treatment duration of 13.2 months at the time of data cutoff (November 1, 2015). In evaluable patients (n = 198), ORR was 62% (95% CI, 54% to 68%), and the disease control rate was 90% (95% CI, 85 to 94). Median duration of response in 122 responding patients was 15.2 months (95% CI, 11.3 to not calculable). Median PFS was 12.3 months (95% CI, 9.5 to 13.8). The most common possibly causally related adverse events (investigator assessed) were diarrhea (43%; grade ≥ 3, < 1%) and rash (grouped terms; 40%; grade ≥ 3, < 1%). Interstitial lung disease (grouped terms) was reported in eight patients (4%; grade 1, n = 2; grade 3, n = 3; grade 5, n = 3). Conclusion In patients with EGFRm T790M advanced NSCLC who progress after EGFR-TKI treatment, osimertinib provides a high ORR, encouraging PFS, and durable response.
440 citations
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St George's, University of London1, University of Oxford2, University of Newcastle3, University of Edinburgh4, University of Maryland, Baltimore5, University of Texas Health Science Center at Houston6, Erasmus University Rotterdam7, Ludwig Maximilian University of Munich8, deCODE genetics9, University of Iceland10, National Institutes of Health11, University of Washington12, Imperial College London13, Boston University14, University of Virginia15, Fred Hutchinson Cancer Research Center16, Utrecht University17, Autonomous University of Barcelona18, Medical University of Graz19, University of Glasgow20, University of Münster21, National University of Ireland, Galway22, University of Cambridge23, Jagiellonian University24, Katholieke Universiteit Leuven25, Lund University26, University of Copenhagen27, University of Kiel28, University of Dundee29, Instituto Nacional de Saúde Dr. Ricardo Jorge30, Instituto de Medicina Molecular31, University Medical Center Utrecht32, Brigham and Women's Hospital33, Broad Institute34, Karolinska Institutet35, University of Pennsylvania36, McMaster University37, University of Mississippi38, Harvard University39, Group Health Research Institute40, University of Mississippi Medical Center41, Mayo Clinic42
TL;DR: The results show that, although genetic variants can be detected in patients with ischaemic stroke when compared with controls, all associations validated are specific to a stroke subtype, and this finding has two implications.
Abstract: Summary Background Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke and its subtypes.
440 citations
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TL;DR: In this article, the electroweak phase transition (EWPhT) in extensions of the Standard Model with one real scalar singlet can be first-order for realistic values of the Higgs mass.
438 citations
Authors
Showing all 38202 results
Name | H-index | Papers | Citations |
---|---|---|---|
Adrian L. Harris | 170 | 1084 | 120365 |
Yang Gao | 168 | 2047 | 146301 |
Alvaro Pascual-Leone | 165 | 969 | 98251 |
David R. Jacobs | 165 | 1262 | 113892 |
Donald G. Truhlar | 165 | 1518 | 157965 |
J. S. Lange | 160 | 2083 | 145919 |
Joseph Wang | 158 | 1282 | 98799 |
José Baselga | 156 | 707 | 122498 |
Stephen J. Chanock | 154 | 1220 | 119390 |
Michael A. Matthay | 151 | 998 | 98687 |
David D'Enterria | 150 | 1592 | 116210 |
G. Eigen | 148 | 2188 | 117450 |
Inkyu Park | 144 | 1767 | 109433 |
Teruki Kamon | 142 | 2034 | 115633 |
Detlef Weigel | 142 | 516 | 84670 |