Institution
Chonbuk National University
Education•Jeonju, South Korea•
About: Chonbuk National University is a education organization based out in Jeonju, South Korea. It is known for research contribution in the topics: Apoptosis & Graphene. The organization has 14820 authors who have published 28884 publications receiving 554131 citations.
Topics: Apoptosis, Graphene, Nanofiber, Population, Electrospinning
Papers published on a yearly basis
Papers
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TL;DR: The findings not only provide the fundamental studies on carbon supported low-dimensional transition-metal oxides but also open up the new possibilities of their applications in green energy devices.
193 citations
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TL;DR: The study suggests that DPP IV inhibitors may ameliorate diabetic nephropathy as well as reduce the overproduction of TGF-β1.
Abstract: Dipeptidyl peptidase (DPP) IV inhibitors are probably beneficial for preventing diabetic complication and modulating glucagon-like peptide-1 receptor (GLP-1R) expression. The aim of this study was to determine whether the DPP IV inhibitor LAF237 (vildagliptin) has renoprotective qualities in streptozotocin-induced diabetic rats. Diabetic and nondiabetic rats were treated with an oral dose of 4 or 8 mg/kg/day LAF237 or placebo for 24 weeks, and renal injury was observed by light and electron microscopy. We also assessed DPP IV activity, active GLP-1 level, cAMP and 8-hydroxy-deoxyguanosine excretion, and GLP-1R, cleaved caspase 3, and transforming growth factor-β1 (TGF-β1) expression. LAF237 significantly decreased proteinuria, albuminuria, and urinary albumin/creatinine ratio, improved creatinine clearance, and dose-dependently inhibited interstitial expansion, glomerulosclerosis, and the thickening of the glomerular basement membrane in diabetic rats. It is noteworthy that LAF237 markedly down-regulated DPP IV activity and increased active GLP-1 levels, which probably prevented oxidative DNA damage and renal cell apoptosis by activating the GLP-1R and modulating cAMP. Renoprotection was also associated with a reduction in TGF-β1 overexpression. Our study suggests that DPP IV inhibitors may ameliorate diabetic nephropathy as well as reduce the overproduction of TGF-β1. The observed renoprotection is probably attributable to inhibition of DPP IV activity, mimicking of incretin action, and activation of the GLP-1R.
192 citations
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TL;DR: Silver-impregnated TiO(2)/nylon-6 nanocomposite mats exhibit excellent characteristics as a filter media with good photocatalytic and antibacterial properties and durability for repeated use and has potential as an economically friendly photocatalyst and water filter media.
192 citations
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TL;DR: Assessment of the host tissue response to poly(lactic-co-glycolic acid) (PLGA)- and small intestinal submucosa (SIS)-based scaffolds subcutaneously implanted in Fischer rats revealed that the PLGA- based scaffolds resulted in severe post-implantation inflammation, whereas the SIS-based scaffold induced only a slight post-injury inflammation.
191 citations
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TL;DR: In this article, the copper oxide (CuO) nanoneedles were synthesized by a simple hydrothermal method and X-ray diffraction (XRD) and selected area electron diffraction results showed that they have monoclinic structure with single crystalline phase.
191 citations
Authors
Showing all 14943 results
Name | H-index | Papers | Citations |
---|---|---|---|
Hyun-Chul Kim | 176 | 4076 | 183227 |
Andrew Ivanov | 142 | 1812 | 97390 |
Dong-Chul Son | 138 | 1370 | 98686 |
C. Haber | 135 | 1507 | 98014 |
Tae Jeong Kim | 132 | 1420 | 93959 |
Alessandro Cerri | 129 | 1244 | 103225 |
Paul M. Vanhoutte | 127 | 868 | 62177 |
Jason Nielsen | 125 | 893 | 72688 |
Chi Lin | 125 | 1313 | 102710 |
Paul Lujan | 123 | 1255 | 76799 |
Young Hee Lee | 122 | 1168 | 61107 |
Min Suk Kim | 119 | 975 | 66214 |
Alexandre Sakharov | 119 | 582 | 56771 |
Yang-Kook Sun | 117 | 781 | 58912 |
Rui L. Reis | 115 | 1608 | 63223 |