Collège de France

About: Collège de France is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Receptor. The organization has 6541 authors who have published 11983 publications receiving 648742 citations. The organization is also known as: College de France.

PTH sensitive adenyl cyclase activity in different segments of the rabbit nephron.

Abstract: PTH sensitive adenylate cyclase activity was measured in 9 different segments of the nephron, isolated by microdissection from collagenase-treated rabbit kidney slices.

How Bad Metals Turn Good: Spectroscopic Signatures of Resilient Quasiparticles

Abstract: We investigate transport in strongly correlated metals. Within dynamical mean-field theory, we calculate the resistivity, thermopower, optical conductivity and thermodynamic properties of a hole-doped Mott insulator. Two well-separated temperature scales are identified: ${T}_{\mathrm{FL}}$ below which Landau Fermi liquid behavior applies, and ${T}_{\mathrm{MIR}}$ above which the resistivity exceeds the Mott-Ioffe-Regel value and bad-metal behavior is found. We show that quasiparticle excitations remain well defined above ${T}_{\mathrm{FL}}$ and dominate transport throughout the intermediate regime ${T}_{\mathrm{FL}}\ensuremath{\lesssim}T\ensuremath{\lesssim}{T}_{\mathrm{MIR}}$. The lifetime of these resilient quasiparticles is longer for electronlike excitations and this pronounced particle-hole asymmetry has important consequences for the thermopower. The crossover into the bad-metal regime corresponds to the disappearance of these excitations and has clear signatures in optical spectroscopy.

VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.

Abstract: Vascular endothelial growth factor C (VEGF-C) was first identified as a regulator of the vascular system, where it is required for the development of lymphatic vessels. Here we report actions of VEGF-C in the central nervous system. We detected the expression of the VEGF-C receptor VEGFR-3 in neural progenitor cells in Xenopus laevis and mouse embryos. In Xenopus tadpole VEGF-C knockdowns and in mice lacking Vegfc, the proliferation of neural progenitors expressing VEGFR-3 was severely reduced, in the absence of intracerebral blood vessel defects. In addition, Vegfc-deficient mouse embryos showed a selective loss of oligodendrocyte precursor cells (OPCs) in the embryonic optic nerve. In vitro, VEGF-C stimulated the proliferation of OPCs expressing VEGFR-3 and nestin-positive ventricular neural cells. VEGF-C thus has a new, evolutionary conserved function as a growth factor selectively required by neural progenitor cells expressing its receptor VEGFR-3.

Mass extinction in poorly known taxa.

Abstract: Since the 1980s, many have suggested we are in the midst of a massive extinction crisis, yet only 799 (0.04%) of the 1.9 million known recent species are recorded as extinct, questioning the reality of the crisis. This low figure is due to the fact that the status of very few invertebrates, which represent the bulk of biodiversity, have been evaluated. Here we show, based on extrapolation from a random sample of land snail species via two independent approaches, that we may already have lost 7% (130,000 extinctions) of the species on Earth. However, this loss is masked by the emphasis on terrestrial vertebrates, the target of most conservation actions. Projections of species extinction rates are controversial because invertebrates are essentially excluded from these scenarios. Invertebrates can and must be assessed if we are to obtain a more realistic picture of the sixth extinction crisis.