Institution
Collège de France
Education•Paris, France•
About: Collège de France is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Receptor. The organization has 6541 authors who have published 11983 publications receiving 648742 citations. The organization is also known as: College de France.
Topics: Population, Receptor, Dopamine, Dopaminergic, Neural crest
Papers published on a yearly basis
Papers
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TL;DR: This series exhibits remarkable efficiency both in terms of stabilization and selectivity, thus combining the performances of the most potent quadruplex binders reported so far, and represents an ideal tradeoff between rapid synthetic access and efficient target recognition.
Abstract: Syntheses and telomeric G-quadruplex−DNA binding properties of novel bisquinolinium compounds are reported. This series exhibits remarkable efficiency both in terms of stabilization and selectivity, thus combining the performances of the most potent quadruplex binders reported so far. These bisquinolinium compounds then represent an ideal tradeoff between rapid synthetic access and efficient target recognition. The study also highlights important structural parameters that lead to the design of highly selective G-quadruplex binders.
371 citations
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TL;DR: Oxygen redox reactivity in the archetypical lithium- and manganese-rich layered cathodes is proved through bulk-sensitive synchrotron-based spectroscopies, and the authors reveal its crucial role in practically important properties.
Abstract: Reversible anionic redox has rejuvenated the search for high-capacity lithium-ion battery cathodes. Real-world success necessitates the holistic mastering of this electrochemistry's kinetics, thermodynamics, and stability. Here we prove oxygen redox reactivity in the archetypical lithium-and manganese-rich layered cathodes through bulk-sensitive synchrotron based spectroscopies, and elucidate their complete anionic/cationic charge-compensation mechanism. Furthermore, via various electroanalytical methods, we answer how the anionic/cationic interplay governs application-wise important issues—namely sluggish kinetics, large hysteresis, and voltage fade—that afflict these promising cathodes despite widespread industrial and academic efforts. We find that cationic redox is kinetically fast and without hysteresis unlike sluggish anions, which furthermore show different oxidation vs. reduction potentials. Additionally, more time spent with fully oxidized oxygen promotes voltage fade. These fundamental insights about anionic redox are indispensable for improving lithium-rich cathodes. Moreover, our methodology provides guidelines for assessing the merits of existing and future anionic redox-based high-energy cathodes, which are being discovered rapidly.
371 citations
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TL;DR: Phosphorylation of vascular endothelial cadherin contributes to a dynamic state of adherens junctions, but is not sufficient to increase vascular permeability in the absence of inflammatory agents.
Abstract: Endothelial adherens junctions maintain vascular integrity. Arteries and veins differ in their permeability but whether organization and strength of their adherens junctions vary has not been demonstrated in vivo. Here we report that vascular endothelial cadherin, an endothelial specific adhesion protein located at adherens junctions, is phosphorylated in Y658 and Y685 in vivo in veins but not in arteries under resting conditions. This difference is due to shear stress-induced junctional Src activation in veins. Phosphorylated vascular endothelial-cadherin is internalized and ubiquitinated in response to permeability-increasing agents such as bradykinin and histamine. Inhibition of Src blocks vascular endothelial cadherin phosphorylation and bradykinin-induced permeability. Point mutation of Y658F and Y685F prevents vascular endothelial cadherin internalization, ubiquitination and an increase in permeability by bradykinin in vitro. Thus, phosphorylation of vascular endothelial cadherin contributes to a dynamic state of adherens junctions, but is not sufficient to increase vascular permeability in the absence of inflammatory agents.
371 citations
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TL;DR: In this paper, Nitrogen-doped carbons were produced using hydrothermal carbonization of nitrogen-containing carbohydrates under mild temperature (180 °C) and the resulting materials contain significant amounts of nitrogen and display a high degree of aromatization.
369 citations
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TL;DR: Astronauts initiated catching movements earlier in 0 g than in 1 g, which demonstrates that the brain uses an internal model of gravity to supplement sensory information when estimating time-to-contact with an approaching object.
Abstract: How does the nervous system synchronize movements to catch a falling ball? According to one theory, only sensory information is used to estimate time-to-contact (TTC) with an approaching object1,2; alternatively, implicit knowledge about physics may come into play3,4. Here we show that astronauts initiated catching movements earlier in 0 g than in 1 g, which demonstrates that the brain uses an internal model of gravity to supplement sensory information when estimating TTC.
367 citations
Authors
Showing all 6597 results
Name | H-index | Papers | Citations |
---|---|---|---|
Pierre Chambon | 211 | 884 | 161565 |
Irving L. Weissman | 201 | 1141 | 172504 |
David R. Williams | 178 | 2034 | 138789 |
Kari Alitalo | 174 | 817 | 114231 |
Pierre Bourdieu | 153 | 592 | 194586 |
Stanislas Dehaene | 149 | 456 | 86539 |
Howard L. Weiner | 144 | 1047 | 91424 |
Alain Fischer | 143 | 770 | 81680 |
Yves Agid | 141 | 669 | 74441 |
Michel Foucault | 140 | 499 | 191296 |
Jean-Pierre Changeux | 138 | 672 | 76462 |
Jean-Marie Tarascon | 136 | 853 | 137673 |
K. Ganga | 132 | 272 | 99004 |
Jacques Delabrouille | 131 | 354 | 94923 |
G. Patanchon | 128 | 241 | 87233 |