Edith Cowan University

About: Edith Cowan University is a education organization based out in Perth, Western Australia, Australia. It is known for research contribution in the topics: Population & Context (language use). The organization has 4040 authors who have published 13529 publications receiving 339582 citations. The organization is also known as: Edith Cowan & ECU.

World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia

Abstract: Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline-from at-risk asymptomatic states to early symptomatic stages-in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.

Changes in the eccentric phase contribute to improved stretch-shorten cycle performance after training

Abstract: Purpose: To determine whether ballistic power training and strength training result in specific changes in stretch-shorten cycle (SSC) function during the eccentric (ECC) phase and, if so, whether these changes are influenced by the individual's strength level. Methods: Thirty-two male subjects were divided into four groups: stronger power training group (SP, n = 8, squat one-repetition maximum-to-body mass ratio (1RM/BM) = 1.97 ± 0.08), weaker power training group (WP, n = 8, 1RM/BM = 1.32 ± 0.14), weaker strength training group (WS, n = 8, 1RM/BM = 1.28 ± 0.17), or control group (C, n = 8, 1RM/BM = 1.37 ± 0.13). Training involved three sessions per week for 10 wk. The SP and WP groups performed maximal-effort jump squats with 0%-30% 1RM, and the WS group performed back squats at 75%-90% 1RM. Maximal strength, jump performance, musculotendinous stiffness, and neural activation were assessed before training and after 5 and 10 wk of training. Results: Both power and strength training elicited significant changes in a multitude of ECC variables that were significantly associated with improvements in concentric (CON) performance. Enhancements in CON performance were theorized to be driven by the development of a strategy to better use the ECC phase during jumping (i.e., greater unloading allowed for increased negative acceleration and thus velocity during the countermovement and improved musculotendinous stiffness resulted in an enhanced ability to translate the momentum developed during the ECC phase into force). Although a significant improvement in maximal strength resulted in changes to SSC function during the ECC phase, the initial strength level did not significantly affect the ECC variables before training or the magnitude of adaptations in individuals exposed to ballistic power training. Conclusions: Training-induced alterations in SSC function during the ECC phase contributes to improvements in jump performance after both ballistic power training and heavy strength training.

Gene mapping in Gypsies identifies a novel demyelinating neuropathy on chromosome 8q24.

Abstract: Founder effect and linkage disequilibrium have been successfully exploited to map single gene disorders1, and the study of isolated populations is emerging as a major approach to the investigation of genetically complex diseases2. In the search for genetic isolates ranging from Pacific islands to Middle East deserts, the 10 million Gypsies resident in Europe3 have largely escaped the attention of geneticists. Because of their geographical ubiquity, lack of written history and the presumed social and cultural nature of their isolation, Gypsies are construed as not meeting the criteria for a well defined founder population. Gypsy society has a complex structure with subdivisions and stratifications that are incomprehensible to the surrounding populations. Marginalization by the health care systems in most countries results in a lack of information on causes of morbidity and mortality and little is known about hereditary disorders or the population genetic characteristics of Gypsies. This study is the first example of mapping a disease gene in endogamous Gypsy groups. Using lod score analysis and linkage disequilibrium, we have located a novel demyelinating neuropathy to a narrow interval on chromosome 8q24. We show that the disease, occuring in Gypsy groups of different identity and history of migrations, is caused by a single mutation whose origin predates the divergence of these groups.