Nanjing University

About: Nanjing University is a education organization based out in Nanjing, China. It is known for research contribution in the topics: Catalysis & Adsorption. The organization has 85961 authors who have published 105504 publications receiving 2289036 citations. The organization is also known as: NJU & Nanking University.

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

Abstract: Cancer cells consume large quantities of glucose and primarily use glycolysis for ATP production, even in the presence of adequate oxygen. This metabolic signature (aerobic glycolysis or the Warburg effect) enables cancer cells to direct glucose to biosynthesis, supporting their rapid growth and proliferation. However, both causes of the Warburg effect and its connection to biosynthesis are not well understood. Here we show that the tumour suppressor p53, the most frequently mutated gene in human tumours, inhibits the pentose phosphate pathway (PPP). Through the PPP, p53 suppresses glucose consumption, NADPH production and biosynthesis. The p53 protein binds to glucose-6-phosphate dehydrogenase (G6PD), the first and rate-limiting enzyme of the PPP, and prevents the formation of the active dimer. Tumour-associated p53 mutants lack the G6PD-inhibitory activity. Therefore, enhanced PPP glucose flux due to p53 inactivation may increase glucose consumption and direct glucose towards biosynthesis in tumour cells.

Nonreciprocal Light Propagation in a Silicon Photonic Circuit

Abstract: Optical communications and computing require on-chip nonreciprocal light propagation to isolate and stabilize different chip-scale optical components. We have designed and fabricated a metallic-silicon waveguide system in which the optical potential is modulated along the length of the waveguide such that nonreciprocal light propagation is obtained on a silicon photonic chip. Nonreciprocal light transport and one-way photonic mode conversion are demonstrated at the wavelength of 1.55 micrometers in both simulations and experiments. Our system is compatible with conventional complementary metal-oxide-semiconductor processing, providing a way to chip-scale optical isolators for optical communications and computing.

A survey of combinatorial testing

Abstract: Combinatorial Testing (CT) can detect failures triggered by interactions of parameters in the Software Under Test (SUT) with a covering array test suite generated by some sampling mechanisms. It has been an active field of research in the last twenty years. This article aims to review previous work on CT, highlights the evolution of CT, and identifies important issues, methods, and applications of CT, with the goal of supporting and directing future practice and research in this area. First, we present the basic concepts and notations of CT. Second, we classify the research on CT into the following categories: modeling for CT, test suite generation, constraints, failure diagnosis, prioritization, metric, evaluation, testing procedure and the application of CT. For each of the categories, we survey the motivation, key issues, solutions, and the current state of research. Then, we review the contribution from different research groups, and present the growing trend of CT research. Finally, we recommend directions for future CT research, including: (1) modeling for CT, (2) improving the existing test suite generation algorithm, (3) improving analysis of testing result, (4) exploring the application of CT to different levels of testing and additional types of systems, (5) conducting more empirical studies to fully understand limitations and strengths of CT, and (6) combining CT with other testing techniques.

Progress and Perspective of Electrocatalytic CO2 Reduction for Renewable Carbonaceous Fuels and Chemicals.

Abstract: The worldwide unrestrained emission of carbon dioxide (CO2) has caused serious environmental pollution and climate change issues. For the sustainable development of human civilization, it is very desirable to convert CO2 to renewable fuels through clean and economical chemical processes. Recently, electrocatalytic CO2 conversion is regarded as a prospective pathway for the recycling of carbon resource and the generation of sustainable fuels. In this review, recent research advances in electrocatalytic CO2 reduction are summarized from both experimental and theoretical aspects. The referred electrocatalysts are divided into different classes, including metal–organic complexes, metals, metal alloys, inorganic metal compounds and carbon-based metal-free nanomaterials. Moreover, the selective formation processes of different reductive products, such as formic acid/formate (HCOOH/HCOO−), monoxide carbon (CO), formaldehyde (HCHO), methane (CH4), ethylene (C2H4), methanol (CH3OH), ethanol (CH3CH2OH), etc. are introduced in detail, respectively. Owing to the limited energy efficiency, unmanageable selectivity, low stability, and indeterminate mechanisms of electrocatalytic CO2 reduction, there are still many tough challenges need to be addressed. In view of this, the current research trends to overcome these obstacles in CO2 electroreduction field are summarized. We expect that this review will provide new insights into the further technique development and practical applications of CO2 electroreduction.

Fe(III)-Doped g-C3N4 Mediated Peroxymonosulfate Activation for Selective Degradation of Phenolic Compounds via High-Valent Iron-Oxo Species.

Abstract: Herein, we proposed a new peroxymonosulfate (PMS) activation system employing the Fe(III) doped g-C3N4 (CNF) as catalyst. Quite different from traditional sulfate radical-based advanced oxidation processes (SR-AOPs), the PMS/CNF system was capable of selectively degrading phenolic compounds (e.g., p-chlorophenol, 4-CP) in a wide pH range (3–9) via nonradical pathway. The generated singlet oxygen (1O2) in the PMS/CNF3 (3.46 wt % Fe) system played negligible role in removing 4-CP, and high-valent iron-oxo species fixated in the nitrogen pots of g-C3N4 (≡FeV═O) was proposed as the dominant reactive species by using dimethyl sulfoxide as a probe compound. The mechanism was hypothesized that PMS was first bound to the Fe(III)-N moieties to generate ≡FeV═O, which effectively reacted with 4-CP via electron transfer. GC-MS analysis indicated that 4-chlorocatechol and 1,4-benzoquinone were the major intermediates, which could be further degraded to carboxylates. The kinetic results suggested that the formation of ...