Nanjing University

About: Nanjing University is a education organization based out in Nanjing, China. It is known for research contribution in the topics: Catalysis & Adsorption. The organization has 85961 authors who have published 105504 publications receiving 2289036 citations. The organization is also known as: NJU & Nanking University.

Mesenchymal stem cell transplantation reverses multiorgan dysfunction in systemic lupus erythematosus mice and humans.

Abstract: Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that, despite the advances in immunosuppressive medical therapies, remains potentially fatal in some patients, especially in treatment-refractory patients. Here, we reported that impairment of bone marrow mesenchymal stem cells (BMMSCs) and their associated osteoblastic niche deficiency contribute in part to the pathogenesis of SLE-like disease in MRL/lpr mice. Interestingly, allogenic BMMSC transplantation (MSCT) is capable of reconstructing the bone marrow osteoblastic niche and more effectively reverses multiorgan dysfunction when compared with medical immunosuppression with cyclophosphamide (CTX). At the cellular level, MSCT, not CTX treatment, was capable to induce osteoblastic niche reconstruction, possibly contributing to the recovery of regulatory T-cells and reestablishment of the immune homeostasis. On the basis of the promising clinical outcomes in SLE mice, we treated four CTX/glucocorticoid treatment-refractory SLE patients using allogenic MSCT and showed a stable 12-18 months disease remission in all treated patients. The patients benefited an amelioration of disease activity, improvement in serologic markers and renal function. These early evidences suggest that allogenic MSCT may be a feasible and safe salvage therapy in refractory SLE patients.

Characterization of collective ground states in single-layer NbSe 2

Abstract: What happens to correlated electronic phases—superconductivity and charge density wave ordering—as a material is thinned? Experiments show that both can remain intact in just a single layer of niobium diselenide.

Role of miR-143 targeting KRAS in colorectal tumorigenesis

Abstract: Dysregulated expression of microRNAs (miRNAs) is associated with a variety of diseases, including colorectal cancer By comparing more than 200 miRNAs in 13 pairs of matched colorectal cancer and normal adjacent tissue samples through qRT-PCR and microarray analysis, we found a widespread disruption of miRNA expression during colorectal tumorigenesis In particular, among a panel of presumed targets generated by in silico analysis that may interact with these aberrantly expressed miRNAs, KRAS oncogene has been further experimentally validated as the target of miR-143 First, an inverse correlation between KRAS protein and miR-143 in vivo was found Second, KRAS expression in Lovo cells was significantly abolished by treatment with miR-143 mimic, whereas miR-143 inhibitor increased KRAS protein level Third, luciferase reporter assay confirmed that miR-143 directly recognize the 3'-untranslated region of KRAS transcripts Four, Lovo cells treated with miR-143 inhibitor showed a stimulated cell proliferation, whereas miR-143 overexpression had an opposite effect Finally, inhibition of KRAS expression by miR-143 inhibits constitutive phosphorylation of ERK1/2 Taken together, the present study provides the first evidences that miR-143 is significant in suppressing colorectal cancer cell growth through inhibition of KRAS translation

Synthesis and characterization of g-C3N4/Ag3VO4 composites with significantly enhanced visible-light photocatalytic activity for triphenylmethane dye degradation

Abstract: The g-C3N4/Ag3VO4 hybrid photocatalysts were prepared by Ag3VO4 anchoring on the surface of g-C3N4. The transmission electron microscope, X-ray diffraction, Fourier transform infrared spectroscopy and X-ray photo-electron spectroscopy analyses demonstrated that Ag3VO4 nanoparticles well distributed on the surface of g-C3N4 and the g-C3N4/Ag3VO4 hetero-junctions were formed. Compared with pure g-C3N4 and Ag3VO4, the g-C3N4/Ag3VO4 hybrid materials displayed much higher photocatalytic activity for basic fuchsin degradation (20 mg/L, 50 mL) under visible-light irradiation. The 40 wt% g-C3N4/Ag3VO4 photocatalyst exhibited optimal removal rate constant of 0.92 h−1, which was 11.5 and 6.6 times higher than that of pure g-C3N4 and Ag3VO4, respectively. Density functional theory calculations indicated that complementary conduction and valence band-edge hybridization between g-C3N4 and Ag3VO4 could apparently increase separation efficiency of electron-hole pairs of g-C3N4/Ag3VO4 composites, which was confirmed by photoluminescence spectra. In addition, it was found that h+ and •O2−1generated in the photocatalytic process played a key role in basic fuchsin degradation.