Pierre-and-Marie-Curie University

About: Pierre-and-Marie-Curie University is a education organization based out in Paris, France. It is known for research contribution in the topics: Population & Raman spectroscopy. The organization has 34448 authors who have published 56139 publications receiving 2392398 citations.

Strength or toughness? A criterion for crack onset at a notch

Abstract: Both energy and stress criteria are necessary conditions for fracture but neither one nor the other are sufficient. Experiments by Parvizi et al. on transverse cracking in cross-ply laminates corroborate this assumption. Thanks to the singularity at the tip of the notch, the incremental form of the energy criterion gives a lower bound of admissible crack lengths. On the contrary, the stress criterion leads to an upper bound. The consistency between these two conditions provides a general form of a criterion for crack nucleation. It enjoys the desirable property of coinciding with the usual Griffith criterion to study the crack growth and with the stress criterion for the uniform traction along a straight edge. Comparisons with experiments carried out on homogeneous notched materials and on bimaterial structures show a good agreement.

Activity-dependent regulation of energy metabolism by astrocytes: an update.

Abstract: Astrocytes play a critical role in the regulation of brain metabolic responses to activity. One detailed mechanism proposed to describe the role of astrocytes in some of these responses has come to be known as the astrocyte-neuron lactate shuttle hypothesis (ANLSH). Although controversial, the original concept of a coupling mechanism between neuronal activity and glucose utilization that involves an activation of aerobic glycolysis in astrocytes and lactate consumption by neurons provides a heuristically valid framework for experimental studies. In this context, it is necessary to provide a survey of recent developments and data pertaining to this model. Thus, here, we review very recent experimental evidence as well as theoretical arguments strongly supporting the original model and in some cases extending it. Aspects revisited include the existence of glutamate-induced glycolysis in astrocytes in vitro, ex vivo, and in vivo, lactate as a preferential oxidative substrate for neurons, and the notion of net lactate transfer between astrocytes and neurons in vivo. Inclusion of a role for glycogen in the ANLSH is discussed in the light of a possible extension of the astrocyte-neuron lactate shuttle (ANLS) concept rather than as a competing hypothesis. New perspectives offered by the application of this concept include a better understanding of the basis of signals used in functional brain imaging, a role for neuron-glia metabolic interactions in glucose sensing and diabetes, as well as novel strategies to develop therapies against neurodegenerative diseases based upon improving astrocyte-neuron coupled energetics.