Showing papers by "Rutgers University published in 2004"
Stanford University1, Cleveland Clinic2, University of Toronto3, Centre national de la recherche scientifique4, Université Paris-Saclay5, University of Paris-Sud6, Avaya7, Rutgers University8, RAND Corporation9, IBM10, University of Pennsylvania11, University of Western Australia12, University of Minnesota13
TL;DR: A publicly available algorithm that requires only the same order of magnitude of computational effort as ordinary least squares applied to the full set of covariates is described.
Abstract: The purpose of model selection algorithms such as All Subsets, Forward Selection and Backward Elimination is to choose a linear model on the basis of the same set of data to which the model will be applied. Typically we have available a large collection of possible covariates from which we hope to select a parsimonious set for the efficient prediction of a response variable. Least Angle Regression (LARS), a new model selection algorithm, is a useful and less greedy version of traditional forward selection methods. Three main properties are derived: (1) A simple modification of the LARS algorithm implements the Lasso, an attractive version of ordinary least squares that constrains the sum of the absolute regression coefficients; the LARS modification calculates all possible Lasso estimates for a given problem, using an order of magnitude less computer time than previous methods. (2) A different LARS modification efficiently implements Forward Stagewise linear regression, another promising new model selection method; this connection explains the similar numerical results previously observed for the Lasso and Stagewise, and helps us understand the properties of both methods, which are seen as constrained versions of the simpler LARS algorithm. (3) A simple approximation for the degrees of freedom of a LARS estimate is available, from which we derive a Cp estimate of prediction error; this allows a principled choice among the range of possible LARS estimates. LARS and its variants are computationally efficient: the paper describes a publicly available algorithm that requires only the same order of magnitude of computational effort as ordinary least squares applied to the full set of covariates.
7,828 citations
TL;DR: Recent findings indicate that network oscillations bias input selection, temporally link neurons into assemblies, and facilitate synaptic plasticity, mechanisms that cooperatively support temporal representation and long-term consolidation of information.
Abstract: Clocks tick, bridges and skyscrapers vibrate, neuronal networks oscillate. Are neuronal oscillations an inevitable by-product, similar to bridge vibrations, or an essential part of the brain’s design? Mammalian cortical neurons form behavior-dependent oscillating networks of various sizes, which span five orders of magnitude in frequency. These oscillations are phylogenetically preserved, suggesting that they are functionally relevant. Recent findings indicate that network oscillations bias input selection, temporally link neurons into assemblies, and facilitate synaptic plasticity, mechanisms that cooperatively support temporal representation and long-term consolidation of information.
5,512 citations
TL;DR: The proposed functional, which includes van der Waals forces in a seamless fashion, is applied to rare gas and benzene dimers, where it is shown to give a realistic description.
Abstract: A scheme within density functional theory is proposed that provides a practical way to generalize to unrestricted geometries the method applied with some success to layered geometries [Phys. Rev. Lett. 91, 126402 (2003)]]. It includes van der Waals forces in a seamless fashion. By expansion to second order in a carefully chosen quantity contained in the long-range part of the correlation functional, the nonlocal correlations are expressed in terms of a density-density interaction formula. It contains a relatively simple parametrized kernel, with parameters determined by the local density and its gradient. The proposed functional is applied to rare gas and benzene dimers, where it is shown to give a realistic description.
4,713 citations
TL;DR: In this paper, the authors compared the natural and anthropogenic controls on the conversion of unreactive N2 to more reactive forms of nitrogen (Nr) and found that human activities increasingly dominate the N budget at the global and at most regional scales, and the terrestrial and open ocean N budgets are essentially dis-connected.
Abstract: This paper contrasts the natural and anthropogenic controls on the conversion of unreactive N2 to more reactive forms of nitrogen (Nr). A variety of data sets are used to construct global N budgets for 1860 and the early 1990s and to make projections for the global N budget in 2050. Regional N budgets for Asia, North America, and other major regions for the early 1990s, as well as the marine N budget, are presented to highlight the dominant fluxes of nitrogen in each region. Important findings are that human activities increasingly dominate the N budget at the global and at most regional scales, the terrestrial and open ocean N budgets are essentially dis- connected, and the fixed forms of N are accumulating in most environmental reservoirs. The largest uncertainties in our understanding of the N budget at most scales are the rates of natural biological nitrogen fixation, the amount of Nr storage in most environmental reservoirs, and the production rates of N2 by denitrification.
4,555 citations
TL;DR: Problem-based learning (PBL) as mentioned in this paper is an instructional method in which students learn through facilitated problem solving, where the teacher acts to facilitate the learning process rather than to provide knowledge.
Abstract: Problem-based approaches to learning have a long history of advocating experience-based education. Psychological research and theory suggests that by having students learn through the experience of solving problems, they can learn both content and thinking strategies. Problem-based learning (PBL) is an instructional method in which students learn through facilitated problem solving. In PBL, student learning centers on a complex problem that does not have a single correct answer. Students work in collaborative groups to identify what they need to learn in order to solve a problem. They engage in self-directed learning (SDL) and then apply their new knowledge to the problem and reflect on what they learned and the effectiveness of the strategies employed. The teacher acts to facilitate the learning process rather than to provide knowledge. The goals of PBL include helping students develop 1) flexible knowledge, 2) effective problem-solving skills, 3) SDL skills, 4) effective collaboration skills, and 5) intrinsic motivation. This article discusses the nature of learning in PBL and examines the empirical evidence supporting it. There is considerable research on the first 3 goals of PBL but little on the last 2. Moreover, minimal research has been conducted outside medical and gifted education. Understanding how these goals are achieved with less skilled learners is an important part of a research agenda for PBL. The evidence suggests that PBL is an instructional approach that offers the potential to help students develop flexible understanding and lifelong learning skills.
3,823 citations
TL;DR: In this paper, the relation between stellar mass and gas-phase metallicity was studied using the Sloan Digital Sky Survey imaging and spectroscopy of ~53,000 star-forming galaxies at z = 0.1.
Abstract: We utilize Sloan Digital Sky Survey imaging and spectroscopy of ~53,000 star-forming galaxies at z ~ 0.1 to study the relation between stellar mass and gas-phase metallicity. We derive gas-phase oxygen abundances and stellar masses using new techniques that make use of the latest stellar evolutionary synthesis and photoionization models. We find a tight (?0.1 dex) correlation between stellar mass and metallicity spanning over 3 orders of magnitude in stellar mass and a factor of 10 in metallicity. The relation is relatively steep from 108.5 to 1010.5 M? h, in good accord with known trends between luminosity and metallicity, but flattens above 1010.5 M?. We use indirect estimates of the gas mass based on the H? luminosity to compare our data to predictions from simple closed box chemical evolution models. We show that metal loss is strongly anticorrelated with baryonic mass, with low-mass dwarf galaxies being 5 times more metal depleted than L* galaxies at z ~ 0.1. Evidence for metal depletion is not confined to dwarf galaxies but is found in galaxies with masses as high as 1010 M?. We interpret this as strong evidence of both the ubiquity of galactic winds and their effectiveness in removing metals from galaxy potential wells.
3,621 citations
Book•
01 Jan 2004TL;DR: In this paper, the critical zeros of the Riemann zeta function are defined and the spacing of zeros is defined. But they are not considered in this paper.
Abstract: Introduction Arithmetic functions Elementary theory of prime numbers Characters Summation formulas Classical analytic theory of $L$-functions Elementary sieve methods Bilinear forms and the large sieve Exponential sums The Dirichlet polynomials Zero-density estimates Sums over finite fields Character sums Sums over primes Holomorphic modular forms Spectral theory of automorphic forms Sums of Kloosterman sums Primes in arithmetic progressions The least prime in an arithmetic progression The Goldbach problem The circle method Equidistribution Imaginary quadratic fields Effective bounds for the class number The critical zeros of the Riemann zeta function The spacing of zeros of the Riemann zeta-function Central values of $L$-functions Bibliography Index.
3,399 citations
TL;DR: A model of two-party (dyadic) knowledge exchange is proposed and test, with strong support in each of the three companies surveyed, and the link between strong ties and receipt of useful knowledge was mediated by competence- and benevolence-based trust.
Abstract: Research has demonstrated that relationships are critical to knowledge creation and transfer, yet findings have been mixed regarding the importance of relational and structural characteristics of social capital for the receipt of tacit and explicit knowledge. We propose and test a model of two-party (dyadic) knowledge exchange, with strong support in each of the three companies surveyed. First, the link between strong ties and receipt of useful knowledge (as reported by the knowledge seeker) was mediated by competence- and benevolence-based trust. Second, once we controlled for these two trustworthiness dimensions, the structural benefit ofweak ties emerged. This finding is consistent with prior research suggesting that weak ties provide access to nonredundant information. Third, competence-based trust was especially important for the receipt of tacit knowledge. We discuss implications for theory and practice.
2,649 citations
TL;DR: A striking interplay between ferroelectricity and magnetism in the multiferroic TbMn2O5 is reported, demonstrated by a highly reproducible electric polarization reversal and permanent polarization imprint that are both actuated by an applied magnetic field.
Abstract: Ferroelectric and magnetic materials are a time-honoured subject of study and have led to some of the most important technological advances to date. Magnetism and ferroelectricity are involved with local spins and off-centre structural distortions, respectively. These two seemingly unrelated phenomena can coexist in certain unusual materials, termed multiferroics1,2,3,4,5,6,7,8,9,10,11. Despite the possible coexistence of ferroelectricity and magnetism, a pronounced interplay between these properties has rarely been observed6,12. This has prevented the realization of multiferroic devices offering such functionality13. Here, we report a striking interplay between ferroelectricity and magnetism in the multiferroic TbMn2O5, demonstrated by a highly reproducible electric polarization reversal and permanent polarization imprint that are both actuated by an applied magnetic field. Our results point to new device applications such as magnetically recorded ferroelectric memory.
1,912 citations
TL;DR: In this article, a reanalysis of broad emission-line reverberation-mapping data was carried out for 35 active galactic nuclei (AGNs) based on a complete and consistent reanalysis, and it was shown that the highest precision measure of the virial product cτΔV2/G is obtained by using the cross-correlation function centroid (cf.
Abstract: We present improved black hole masses for 35 active galactic nuclei (AGNs) based on a complete and consistent reanalysis of broad emission-line reverberation-mapping data From objects with multiple line measurements, we find that the highest precision measure of the virial product cτΔV2/G, where τ is the emission-line lag relative to continuum variations and ΔV is the emission-line width, is obtained by using the cross-correlation function centroid (as opposed to the cross-correlation function peak) for the time delay and the line dispersion (as opposed to FWHM) for the line width and by measuring the line width in the variable part of the spectrum Accurate line-width measurement depends critically on avoiding contaminating features, in particular the narrow components of the emission lines We find that the precision (or random component of the error) of reverberation-based black hole mass measurements is typically around 30%, comparable to the precision attained in measurement of black hole masses in quiescent galaxies by gas or stellar dynamical methods Based on results presented in a companion paper by Onken et al, we provide a zero-point calibration for the reverberation-based black hole mass scale by using the relationship between black hole mass and host-galaxy bulge velocity dispersion The scatter around this relationship implies that the typical systematic uncertainties in reverberation-based black hole masses are smaller than a factor of 3 We present a preliminary version of a mass-luminosity relationship that is much better defined than any previous attempt Scatter about the mass-luminosity relationship for these AGNs appears to be real and could be correlated with either Eddington ratio or object inclination
1,893 citations
TL;DR: Large-scale recordings from neuronal ensembles now offer the opportunity to test competing theoretical frameworks and require further development of the neuron–electrode interface, automated and efficient spike-sorting algorithms for effective isolation and identification of single neurons, and new mathematical insights for the analysis of network properties.
Abstract: How does the brain orchestrate perceptions, thoughts and actions from the spiking activity of its neurons? Early single-neuron recording research treated spike pattern variability as noise that needed to be averaged out to reveal the brain's representation of invariant input. Another view is that variability of spikes is centrally coordinated and that this brain-generated ensemble pattern in cortical structures is itself a potential source of cognition. Large-scale recordings from neuronal ensembles now offer the opportunity to test these competing theoretical frameworks. Currently, wire and micro-machined silicon electrode arrays can record from large numbers of neurons and monitor local neural circuits at work. Achieving the full potential of massively parallel neuronal recordings, however, will require further development of the neuron–electrode interface, automated and efficient spike-sorting algorithms for effective isolation and identification of single neurons, and new mathematical insights for the analysis of network properties.
TL;DR: MiRNA172 likely acts in cell-fate specification as a translational repressor of APETALA2 in Arabidopsis flower development and results in floral organ identity defects similar to those in loss-of-function apetala2 mutants.
Abstract: Plant microRNAs (miRNAs) show a high degree of sequence complementarity to, and are believed to guide the cleavage of, their target messenger RNAs. Here, I show that miRNA172, which can base-pair with the messenger RNA of a floral homeotic gene, APETALA2, regulates APETALA2 expression primarily through translational inhibition. Elevated miRNA172 accumulation results in floral organ identity defects similar to those in loss-of-function apetala2 mutants. Elevated levels of mutant APETALA2 RNA with disrupted miRNA172 base pairing, but not wild-type APETALA2 RNA, result in elevated levels of APETALA2 protein and severe floral patterning defects. Therefore, miRNA172 likely acts in cell-fate specification as a translational repressor of APETALA2 in Arabidopsis flower development.
TL;DR: The authors illustrate the utility of the multidimensional organizing framework by analyzing the different configuration of elements in 4 major theories of identification.
Abstract: The authors offer a framework for conceptualizing collective identity that aims to clarify and make distinctions among dimensions of identification that have not always been clearly articulated. Elements of collective identification included in this framework are self-categorization, evaluation, importance, attachment and sense of interdependence, social embeddedness, behavioral involvement, and content and meaning. For each element, the authors take note of different labels that have been used to identify what appear to be conceptually equivalent constructs, provide examples of studies that illustrate the concept, and suggest measurement approaches. Further, they discuss the potential links between elements and outcomes and how context moderates these relationships. The authors illustrate the utility of the multidimensional organizing framework by analyzing the different configuration of elements in 4 major theories of identification.
TL;DR: This method, which eliminates exposure of the fragile organic surface to the hazards of conventional processing, enables fabrication of rubrene transistors with charge carrier mobilities as high as ∼15 cm2/V·s and subthreshold slopes as low as 2nF·V/decade·cm2.
Abstract: We introduce a method to fabricate high-performance field-effect transistors on the surface of freestanding organic single crystals. The transistors are constructed by laminating a monolithic elastomeric transistor stamp against the surface of a crystal. This method, which eliminates exposure of the fragile organic surface to the hazards of conventional processing, enables fabrication of rubrene transistors with charge carrier mobilities as high as approximately 15 cm2/V.s and subthreshold slopes as low as 2nF.V/decade.cm2. Multiple relamination of the transistor stamp against the same crystal does not affect the transistor characteristics; we exploit this reversibility to reveal anisotropic charge transport at the basal plane of rubrene.
TL;DR: A Markov chain Monte Carlo method for estimating the posterior probability distribution of model parameters is applied to a large multilocus data set from Drosophila pseudoobscura and D. persimilis, with considerable variation in gene flow estimates among loci, in both directions between the species.
Abstract: The genetic study of diverging, closely related populations is required for basic questions on demography and speciation, as well as for biodiversity and conservation research. However, it is often unclear whether divergence is due simply to separation or whether populations have also experienced gene flow. These questions can be addressed with a full model of population separation with gene flow, by applying a Markov chain Monte Carlo method for estimating the posterior probability distribution of model parameters. We have generalized this method and made it applicable to data from multiple unlinked loci. These loci can vary in their modes of inheritance, and inheritance scalars can be implemented either as constants or as parameters to be estimated. By treating inheritance scalars as parameters it is also possible to address variation among loci in the impact via linkage of recurrent selective sweeps or background selection. These methods are applied to a large multilocus data set from Drosophila pseudoobscura and D. persimilis. The species are estimated to have diverged ∼500,000 years ago. Several loci have nonzero estimates of gene flow since the initial separation of the species, with considerable variation in gene flow estimates among loci, in both directions between the species.
TL;DR: The geological, geochemical, and biological processes that contributed to the rise of the dinoflagellates, coccolithophores, and diatoms all contain plastids derived from an ancestral red alga by secondary symbiosis are examined.
Abstract: The community structure and ecological function of contemporary marine ecosystems are critically dependent on eukaryotic phytoplankton. Although numerically inferior to cyanobacteria, these organisms are responsible for the majority of the flux of organic matter to higher trophic levels and the ocean interior. Photosynthetic eukaryotes evolved more than 1.5 billion years ago in the Proterozoic oceans. However, it was not until the Mesozoic Era (251 to 65 million years ago) that the three principal phytoplankton clades that would come to dominate the modern seas rose to ecological prominence. In contrast to their pioneering predecessors, the dinoflagellates, coccolithophores, and diatoms all contain plastids derived from an ancestral red alga by secondary symbiosis. Here we examine the geological, geochemical, and biological processes that contributed to the rise of these three, distantly related, phytoplankton groups.
TL;DR: Gaining better insight into the mechanisms of these effects could lessen or even eliminate the empiricism used to determine the optimal dose and schedule for metronomic chemotherapy regimens.
Abstract: In addition to proliferating cancer cells and various types of normal cells, such as those of the bone marrow, conventional cytotoxic chemotherapeutics affect the endothelium of the growing tumour vasculature. The anti-angiogenic efficacy of chemotherapy seems to be optimized by administering comparatively low doses of drug on a frequent or continuous schedule, with no extended interruptions — sometimes referred to as 'metronomic' chemotherapy. In addition to reduced acute toxicity, the efficacy of metronomic chemotherapy seems to increase when administered in combination with specific anti-angiogenic drugs. Gaining better insight into the mechanisms of these effects could lessen or even eliminate the empiricism used to determine the optimal dose and schedule for metronomic chemotherapy regimens.
TL;DR: A model is proposed whereby SNP309 serves as a rate-limiting event in carcinogenesis, and a single nucleotide polymorphism (SNP309) is found in the MDM2 promoter and is shown to increase the affinity of the transcriptional activator Sp1, resulting in higher levels ofMDM2 RNA and protein and the subsequent attenuation of the p53 pathway.
TL;DR: A real-time and retrospective North American Land Data Assimilation System (NLDAS) is presented in this article, which consists of four land models executing in parallel in uncoupled mode, common hourly surface forcing, and common streamflow routing: all using a 1/8° grid over the continental United States.
Abstract: [1] Results are presented from the multi-institution partnership to develop a real-time and retrospective North American Land Data Assimilation System (NLDAS). NLDAS consists of (1) four land models executing in parallel in uncoupled mode, (2) common hourly surface forcing, and (3) common streamflow routing: all using a 1/8° grid over the continental United States. The initiative is largely sponsored by the Global Energy and Water Cycle Experiment (GEWEX) Continental-Scale International Project (GCIP). As the overview for nine NLDAS papers, this paper describes and evaluates the 3-year NLDAS execution of 1 October 1996 to 30 September 1999, a period rich in observations for validation. The validation emphasizes (1) the land states, fluxes, and input forcing of four land models, (2) the application of new GCIP-sponsored products, and (3) a multiscale approach. The validation includes (1) mesoscale observing networks of land surface forcing, fluxes, and states, (2) regional snowpack measurements, (3) daily streamflow measurements, and (4) satellite-based retrievals of snow cover, land surface skin temperature (LST), and surface insolation. The results show substantial intermodel differences in surface evaporation and runoff (especially over nonsparse vegetation), soil moisture storage, snowpack, and LST. Owing to surprisingly large intermodel differences in aerodynamic conductance, intermodel differences in midday summer LST were unlike those expected from the intermodel differences in Bowen ratio. Last, anticipating future assimilation of LST, an NLDAS effort unique to this overview paper assesses geostationary-satellite-derived LST, determines the latter to be of good quality, and applies the latter to validate modeled LST.
TL;DR: In this article, the authors present a methodology for investigating regional vulnerability to climate change in combination with other global stressors, which relies on both vulnerability mapping and local-level case studies, and can serve as a basis for targeting policy interventions.
Abstract: There is growing recognition in the human dimensions research community that climate change impact studies must take into account the effects of other ongoing global changes. Yet there has been no systematic methodology to study climate change vulnerability in the context of multiple stressors. Using the example of Indian agriculture, this paper presents a methodology for investigating regional vulnerability to climate change in combination with other global stressors. This method, which relies on both vulnerability mapping and local-level case studies, may be used to assess differential vulnerability for any particular sector within a nation or region, and it can serve as a basis for targeting policy interventions.
TL;DR: These cytokines have significant roles in a variety of pathophysiological processes as well as in regulation of the immune system and further investigation of these critical intercellular signaling molecules will provide important information to enable these proteins to be used more extensively in therapy for a range of diseases.
Abstract: ▪ Abstract The Class 2 α-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22, IL-24 (Mda-7), and IL-26, interferons (IFN-α, -β, -ɛ, -κ, -ω, -δ, -τ, and -γ) and interferon-like molecules (limitin, IL-28A, IL-28B, and IL-29). The interaction of these cytokines with their specific receptor molecules initiates a broad and varied array of signals that induce cellular antiviral states, modulate inflammatory responses, inhibit or stimulate cell growth, produce or inhibit apoptosis, and affect many immune mechanisms. The information derived from crystal structures and molecular evolution has led to progress in the analysis of the molecular mechanisms initiating their biological activities. These cytokines have significant roles in a variety of pathophysiological processes as well as in regulation of the immune system. Further investigation of these critical intercellular signaling molecules will provide important information to enable these proteins to be used more extensively in therapy for ...
TL;DR: The air-gap field-effect technique enabled realization of the intrinsic (not limited by static disorder) polaronic transport on the surface of rubrene (C42H28) crystals over a wide temperature range.
Abstract: The air-gap field-effect technique enabled realization of the intrinsic (not limited by static disorder) polaronic transport on the surface of rubrene (C42H28) crystals over a wide temperature range. The signatures of this intrinsic transport are the anisotropy of the carrier mobility, mu, and the growth of mu with cooling. Anisotropy of mu vanishes in the activation regime at low temperatures, where the transport is dominated by shallow traps. The deep traps, introduced by x-ray radiation, increase the field-effect threshold without affecting mu, an indication that the filled traps do not scatter polarons.
TL;DR: The phase diagram of the bistable lactose utilization network of Escherichia coli is presented, coupled with a mathematical model of the network, to quantitatively investigate processes such as sugar uptake and transcriptional regulation in vivo and shows how the hysteretic response of the wild-type system can be converted to an ultrasensitive graded response.
Abstract: Multistability, the capacity to achieve multiple internal states in response to a single set of external inputs, is the defining characteristic of a switch. Biological switches are essential for the determination of cell fate in multicellular organisms1, the regulation of cell-cycle oscillations during mitosis2,3 and the maintenance of epigenetic traits in microbes4. The multistability of several natural1,2,3,4,5,6 and synthetic7,8,9 systems has been attributed to positive feedback loops in their regulatory networks10. However, feedback alone does not guarantee multistability. The phase diagram of a multistable system, a concise description of internal states as key parameters are varied, reveals the conditions required to produce a functional switch11,12. Here we present the phase diagram of the bistable lactose utilization network of Escherichia coli13. We use this phase diagram, coupled with a mathematical model of the network, to quantitatively investigate processes such as sugar uptake and transcriptional regulation in vivo. We then show how the hysteretic response of the wild-type system can be converted to an ultrasensitive graded response14,15. The phase diagram thus serves as a sensitive probe of molecular interactions and as a powerful tool for rational network design.
Vanderbilt University1, University of Southern California2, University of Texas MD Anderson Cancer Center3, University of Wisconsin-Madison4, University of California, Los Angeles5, National Center for Genome Resources6, Portland VA Medical Center7, University of Colorado Boulder8, University of Pennsylvania9, Hannover Medical School10, Johns Hopkins University11, Oregon Health & Science University12, Cornell University13, University of Michigan14, University of Tennessee Health Science Center15, Washington University in St. Louis16, University of Toronto17, University of Memphis18, Medical Research Council19, University of Massachusetts Medical School20, Hebrew University of Jerusalem21, Université de Montréal22, Purdue University23, University of California, Davis24, Academy of Sciences of the Czech Republic25, University at Buffalo26, Emory University27, University of Cincinnati28, University of Texas Southwestern Medical Center29, New York University30, University of Groningen31, Rutgers University32, Stanford University33, Max Planck Society34, National Institutes of Health35, University of Alabama at Birmingham36, International Livestock Research Institute37, Heidelberg University38, Medical College of Wisconsin39, Icahn School of Medicine at Mount Sinai40, Oak Ridge National Laboratory41, Charité42, University of Antwerp43, RWTH Aachen University44, Paul Sabatier University45, University of California, San Francisco46, McGill University47, Pasteur Institute48, University of Western Australia49, Yale University50, University of Oxford51, Case Western Reserve University52, Roswell Park Cancer Institute53, University of Kentucky54, University of Helsinki55, University of Nebraska–Lincoln56, Harvard University57, Merck & Co.58, King's College London59, Northwestern University60, Shriners Hospitals for Children61, Thomas Jefferson University62, Novartis63, University of North Carolina at Chapel Hill64, Southern Illinois University Carbondale65, University of Rochester66
TL;DR: The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way the authors approach human health and disease.
Abstract: The goal of the Complex Trait Consortium is to promote the development of resources that can be used to understand, treat and ultimately prevent pervasive human diseases. Existing and proposed mouse resources that are optimized to study the actions of isolated genetic loci on a fixed background are less effective for studying intact polygenic networks and interactions among genes, environments, pathogens and other factors. The Collaborative Cross will provide a common reference panel specifically designed for the integrative analysis of complex systems and will change the way we approach human health and disease.
TL;DR: In this paper, the authors examined the effect of CEO compensation contracts on misreporting and found that the sensitivity of the CEO's option portfolio to stock price is significantly positively related to the propensity to misreport.
Abstract: This paper examines the effect of CEO compensation contracts on misreporting We find that the sensitivity of the CEO's option portfolio to stock price is significantly positively related to the propensity to misreport We do not find that the sensitivity of other components of CEO compensation, ie, equity, restricted stock, long-term incentive payouts and salary and bonus have any significant impact on the propensity to misreport Relative to other components of compensation, stock options are associated with stronger incentives to misreport because convexity in CEO wealth introduced by stock options limits the downside risk on detection of the misreporting
TL;DR: In this paper, the authors derived a second-order approximation to the solution of a general class of discretetime rational expectations models, and showed that the coe1cients on the terms linear and quadratic in the state vector are independent of the volatility of the exogenous shocks.
TL;DR: In this article, a multilevel study of 257 employees, 44 managers, and 1,993 customers from 25 restaurants was conducted to investigate the service performance of 25 restaurants in the US.
Abstract: Previous work on service performance has focused on either organization- or individual-level analysis. This multilevel study of 257 employees, 44 managers, and 1,993 customers from 25 restaurants d...
TL;DR: In this paper, a three-stage model of guanxi development is proposed to stimulate systematic research in this area, and a conceptual and theoretical discussion of Guanxi bases, objectives, and operating principles at different stages of the development process are discussed.
Abstract: Guanxi (personal connection) has been identified as a necessary condition to do business successfully in China. In this paper, we seek a clear conceptual understanding of this prevalent construct and propose a three-stage model of guanxi development so as to stimulate systematic research in this area. Our conceptual and theoretical discussion of guanxi bases,guanxi objectives, and the operating principles at different stages of guanxi development will also help practitioners to use guanxi more effectively.
TL;DR: This paper reviews studies that investigate the effects of plants on metals in wetlands and suggests that metals in litter are available to deposit feeders and, thus, can enter estuarine food webs.
TL;DR: It is suggested that potentiated LA outputs disinhibit CE projection neurons via GABAergic intercalated neurons, thereby permitting associative plasticity in CE, and accounts for inhibition of conditioned fear after extinction.
Abstract: It is currently believed that the acquisition of classically conditioned fear involves potentiation of conditioned thalamic inputs in the lateral amygdala (LA). In turn, LA cells would excite more neurons in the central nucleus (CE) that, via their projections to the brain stem and hypothalamus, evoke fear responses. However, LA neurons do not directly contact brain stem-projecting CE neurons. This is problematic because CE projections to the periaqueductal gray and pontine reticular formation are believed to generate conditioned freezing and fear-potentiated startle, respectively. Moreover, like LA, CE may receive direct thalamic inputs communicating information about the conditioned and unconditioned stimuli. Finally, recent evidence suggests that the CE itself may be a critical site of plasticity. This review attempts to reconcile the current model with these observations. We suggest that potentiated LA outputs disinhibit CE projection neurons via GABAergic intercalated neurons, thereby permitting associative plasticity in CE. Thus plasticity in both LA and CE would be necessary for acquisition of conditioned fear. This revised model also accounts for inhibition of conditioned fear after extinction.