Institution
The Chinese University of Hong Kong
Education•Hong Kong, China•
About: The Chinese University of Hong Kong is a education organization based out in Hong Kong, China. It is known for research contribution in the topics: Population & Computer science. The organization has 43411 authors who have published 93672 publications receiving 3066651 citations.
Topics: Population, Computer science, Cancer, Medicine, China
Papers published on a yearly basis
Papers
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TL;DR: Complicated peptic ulcer remains a substantial healthcare problem which places patients at a high risk of recurrent complications and death.
Abstract: Background/Aims: The incidence of uncomplicated peptic ulcer has decreased in recent years. It is unclear what the impact of this has been on the epidemiology of peptic ulcer compli
412 citations
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TL;DR: For macroscopically solitary HCC, a resection margin aiming grossly at 2 cm efficaciously and safely decreased postoperative recurrence rate and improved survival outcomes when compared with a gross resectionmargin aiming at 1 cm, especially for HCC ≤2 cm.
Abstract: Objective:To compare the efficacy and safety of partial hepatectomy aiming grossly at a narrow (1 cm) and a wide (2 cm) resection margin in patients with macroscopically solitary hepatocellular carcinoma (HCC).Summary Background Data:For HCC treated with partial hepatectomy, the extent of the margin
412 citations
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TL;DR: The proximate composition, amino acid profile and some physico-chemical properties of two subtropical red seaweeds (Hypnea charoides and Hypnea japonica) and one green seaweed (Ulva lactuca) were investigated as mentioned in this paper.
412 citations
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TL;DR: Analysis of TCC by whole-genome and whole-exome sequencing provides evidence that genetic alterations affecting the SCCS process may be involved in bladder tumorigenesis and identifies a new therapeutic possibility for bladder cancer.
Abstract: Bladder cancer is one of the most common cancers worldwide, with transitional cell carcinoma (TCC) being the predominant form. Here we report a genomic analysis of TCC by both whole-genome and whole-exome sequencing of 99 individuals with TCC. Beyond confirming recurrent mutations in genes previously identified as being mutated in TCC, we identified additional altered genes and pathways that were implicated in TCC. Notably, we discovered frequent alterations in STAG2 and ESPL1, two genes involved in the sister chromatid cohesion and segregation (SCCS) process. Furthermore, we also detected a recurrent fusion involving FGFR3 and TACC3, another component of SCCS, by transcriptome sequencing of 42 DNA-sequenced tumors. Overall, 32 of the 99 tumors (32%) harbored genetic alterations in the SCCS process. Our analysis provides evidence that genetic alterations affecting the SCCS process may be involved in bladder tumorigenesis and identifies a new therapeutic possibility for bladder cancer.
411 citations
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TL;DR: In medically refractory patients with high-grade intracranial atherosclerotic stenoses, a new treatment paradigm involving predilation with an undersized Gateway percutaneous transluminal angioplasty balloon catheter and placement of a self-expanding Wingspan stent system appears to be safe, may facilitate remodeling, and may contribute to favorable angiographic outcomes.
Abstract: Background and Purpose— The purpose of this study was to assess the safety and performance of the Wingspan stent system and Gateway percutaneous transluminal angioplasty balloon catheter in the treatment of high-grade, intracranial atherosclerotic lesions in patients who had failed medical therapy. Methods— In this prospective, multicenter, single-arm study, medically refractory patients with a modified Rankin score ≤3 and recurrent symptoms attributable to angiographically demonstrated intracranial stenosis ≥50% in a vessel 2.5 to 4.5 mm in diameter were enrolled. Intracranial lesions were predilated with an undersized Gateway balloon catheter to 80% of the native vessel diameter, followed by deployment of the self-expanding Wingspan stent to facilitate further remodeling of the atherosclerotic plaque and to maintain vessel patency. Neurologic examinations and angiograms were performed at 6 months after the procedure. Results— Among the 45 patients enrolled, the degree of stenosis was reduced from a baseline of 74.9±9.8% to 31.9±13.6% after stenting and 28±23.2% at the 6-month follow-up. The 30-day composite ipsilateral stroke/death rate was 4.5% (2/44); at the 6-month follow-up, the ipsilateral stroke/death rate was 7.0%, the rate for all strokes was 9.7%, and all-cause mortality was 2.3%. Physician-reported follow-up in 43 patients (average of 13 months) conducted outside the study protocol (not adjudicated by the clinical event committee) reported 1 additional ipsilateral stroke. Conclusions— In medically refractory patients with high-grade intracranial atherosclerotic stenoses, a new treatment paradigm involving predilation with an undersized Gateway percutaneous transluminal angioplasty balloon catheter and placement of a self-expanding Wingspan stent system appears to be safe, may facilitate remodeling, and may contribute to favorable angiographic outcomes.
411 citations
Authors
Showing all 43993 results
Name | H-index | Papers | Citations |
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Michael Marmot | 193 | 1147 | 170338 |
Jing Wang | 184 | 4046 | 202769 |
Jiaguo Yu | 178 | 730 | 113300 |
Yang Yang | 171 | 2644 | 153049 |
Mark Gerstein | 168 | 751 | 149578 |
Gang Chen | 167 | 3372 | 149819 |
Jun Wang | 166 | 1093 | 141621 |
Jean Louis Vincent | 161 | 1667 | 163721 |
Wei Zheng | 151 | 1929 | 120209 |
Rui Zhang | 151 | 2625 | 107917 |
Ben Zhong Tang | 149 | 2007 | 116294 |
Kypros H. Nicolaides | 147 | 1302 | 87091 |
Thomas S. Huang | 146 | 1299 | 101564 |
Galen D. Stucky | 144 | 958 | 101796 |
Joseph J.Y. Sung | 142 | 1240 | 92035 |