Institution
The Chinese University of Hong Kong
Education•Hong Kong, China•
About: The Chinese University of Hong Kong is a education organization based out in Hong Kong, China. It is known for research contribution in the topics: Population & Computer science. The organization has 43411 authors who have published 93672 publications receiving 3066651 citations.
Topics: Population, Computer science, Cancer, Medicine, China
Papers published on a yearly basis
Papers
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TL;DR: The traditional constrained approach performed more poorly than did 3 new approaches--unconstrained, generalized appended product indicator, and quasi-maximum-likelihood (QML); the authors' new unconstrained approach was easiest to apply.
Abstract: Interactions between (multiple indicator) latent variables are rarely used because of implementation complexity and competing strategies. Based on 4 simulation studies, the traditional constrained approach performed more poorly than did 3 new approaches--unconstrained, generalized appended product indicator, and quasi-maximum-likelihood (QML). The authors' new unconstrained approach was easiest to apply. All 4 approaches were relatively unbiased for normally distributed indicators, but the constrained and QML approaches were more biased for nonnormal data; the size and direction of the bias varied with the distribution but not with the sample size. QML had more power, but this advantage was qualified by consistently higher Type I error rates. The authors also compared general strategies for defining product indicators to represent the latent interaction factor.
891 citations
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TL;DR: This review highlights issues to consider when implementing a CRC screening programme and gives a worldwide overview of CRC burden and the current status of screening programmes, with focus on international differences.
Abstract: Colorectal cancer (CRC) ranks third among the most commonly diagnosed cancers worldwide, with wide geographical variation in incidence and mortality across the world. Despite proof that screening can decrease CRC incidence and mortality, CRC screening is only offered to a small proportion of the target population worldwide. Throughout the world there are widespread differences in CRC screening implementation status and strategy. Differences can be attributed to geographical variation in CRC incidence, economic resources, healthcare structure and infrastructure to support screening such as the ability to identify the target population at risk and cancer registry availability. This review highlights issues to consider when implementing a CRC screening programme and gives a worldwide overview of CRC burden and the current status of screening programmes, with focus on international differences.
887 citations
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TL;DR: On-going and future clinical trials on sarcopenia may radically change the authors' preventive and therapeutic approaches of mobility disability in older people.
Abstract: Sarcopenia is a loss of muscle protein mass and loss of muscle function. It occurs with increasing age, being a major component in the development of frailty. Current knowledge on its assessment, etiology, pathogenesis, consequences and future perspectives are reported in the present review. On-going and future clinical trials on sarcopenia may radically change our preventive and therapeutic approaches of mobility disability in older people.
886 citations
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TL;DR: A genome-wide association scan is performed, followed by replication studies in three populations of European descent and a Chinese population from Hong Kong and a strong association is found between two sequence variants on chromosome 4q25 and AF.
Abstract: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans and is characterized by chaotic electrical activity of the atria. It affects one in ten individuals over the age of 80 years, causes significant morbidity and is an independent predictor of mortality. Recent studies have provided evidence of a genetic contribution to AF. Mutations in potassium-channel genes have been associated with familial AF but account for only a small fraction of all cases of AF. We have performed a genome-wide association scan, followed by replication studies in three populations of European descent and a Chinese population from Hong Kong and find a strong association between two sequence variants on chromosome 4q25 and AF. Here we show that about 35% of individuals of European descent have at least one of the variants and that the risk of AF increases by 1.72 and 1.39 per copy. The association with the stronger variant is replicated in the Chinese population, where it is carried by 75% of individuals and the risk of AF is increased by 1.42 per copy. A stronger association was observed in individuals with typical atrial flutter. Both variants are adjacent to PITX2, which is known to have a critical function in left-right asymmetry of the heart.
882 citations
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University of Ottawa1, World Health Organization2, University of Pittsburgh3, King Saud bin Abdulaziz University for Health Sciences4, University of Edinburgh5, University of Jena6, Utrecht University7, Oswaldo Cruz Foundation8, Monash University9, Public Health England10, Liverpool School of Tropical Medicine11, University of Liverpool12, University of Oxford13, The Chinese University of Hong Kong14, Imperial College London15, Sungkyunkwan University16, Trinity College, Dublin17, Queen's University Belfast18, Johns Hopkins University19, University of Bonn20, Radboud University Nijmegen21, Seoul National University22, University of Brescia23, Beijing University of Chinese Medicine24, Centers for Disease Control and Prevention25, Tianjin University of Traditional Chinese Medicine26
TL;DR: A minimum set of common outcome measures for studies of COVID-19, which includes a measure of viral burden, patient survival, and patient progression through the health-care system by use of the WHO Clinical Progression Scale are urged.
Abstract: Summary Clinical research is necessary for an effective response to an emerging infectious disease outbreak. However, research efforts are often hastily organised and done using various research tools, with the result that pooling data across studies is challenging. In response to the needs of the rapidly evolving COVID-19 outbreak, the Clinical Characterisation and Management Working Group of the WHO Research and Development Blueprint programme, the International Forum for Acute Care Trialists, and the International Severe Acute Respiratory and Emerging Infections Consortium have developed a minimum set of common outcome measures for studies of COVID-19. This set includes three elements: a measure of viral burden (quantitative PCR or cycle threshold), a measure of patient survival (mortality at hospital discharge or at 60 days), and a measure of patient progression through the health-care system by use of the WHO Clinical Progression Scale, which reflects patient trajectory and resource use over the course of clinical illness. We urge investigators to include these key data elements in ongoing and future studies to expedite the pooling of data during this immediate threat, and to hone a tool for future needs.
882 citations
Authors
Showing all 43993 results
Name | H-index | Papers | Citations |
---|---|---|---|
Michael Marmot | 193 | 1147 | 170338 |
Jing Wang | 184 | 4046 | 202769 |
Jiaguo Yu | 178 | 730 | 113300 |
Yang Yang | 171 | 2644 | 153049 |
Mark Gerstein | 168 | 751 | 149578 |
Gang Chen | 167 | 3372 | 149819 |
Jun Wang | 166 | 1093 | 141621 |
Jean Louis Vincent | 161 | 1667 | 163721 |
Wei Zheng | 151 | 1929 | 120209 |
Rui Zhang | 151 | 2625 | 107917 |
Ben Zhong Tang | 149 | 2007 | 116294 |
Kypros H. Nicolaides | 147 | 1302 | 87091 |
Thomas S. Huang | 146 | 1299 | 101564 |
Galen D. Stucky | 144 | 958 | 101796 |
Joseph J.Y. Sung | 142 | 1240 | 92035 |