Institution
University of Bordeaux
Education•Bordeaux, France•
About: University of Bordeaux is a education organization based out in Bordeaux, France. It is known for research contribution in the topics: Population & Laser. The organization has 28811 authors who have published 55536 publications receiving 1619635 citations. The organization is also known as: UB.
Topics: Population, Laser, Context (language use), Raman spectroscopy, Medicine
Papers published on a yearly basis
Papers
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TL;DR: A system analysis of the neutralizing antibody response to a trivalent inactivated seasonal influenza vaccine and a large number of immune system components finds a strong association between androgens and genes involved in lipid metabolism, suggesting that these could be important drivers of the differences in immune responses between males and females.
Abstract: Females have generally more robust immune responses than males for reasons that are not well-understood. Here we used a systems analysis to investigate these differences by analyzing the neutralizing antibody response to a trivalent inactivated seasonal influenza vaccine (TIV) and a large number of immune system components, including serum cytokines and chemokines, blood cell subset frequencies, genome-wide gene expression, and cellular responses to diverse in vitro stimuli, in 53 females and 34 males of different ages. We found elevated antibody responses to TIV and expression of inflammatory cytokines in the serum of females compared with males regardless of age. This inflammatory profile correlated with the levels of phosphorylated STAT3 proteins in monocytes but not with the serological response to the vaccine. In contrast, using a machine learning approach, we identified a cluster of genes involved in lipid biosynthesis and previously shown to be up-regulated by testosterone that correlated with poor virus-neutralizing activity in men. Moreover, men with elevated serum testosterone levels and associated gene signatures exhibited the lowest antibody responses to TIV. These results demonstrate a strong association between androgens and genes involved in lipid metabolism, suggesting that these could be important drivers of the differences in immune responses between males and females.
518 citations
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TL;DR: In this article, the ring-opening polymerization of various lactones and lactides initiated by lanthanum isopropoxide has been investigated, and the corresponding thermodynamic parameters and the equilibrium monomer concentrations have been calculated.
Abstract: Ring-opening polymerization of various lactones and lactides initiated by lanthanum isopropoxide has been investigated. Analysis of molecular weights and molecular-weight distributions of the resulting polymers shows that the ring-opening process is a controlled reaction, which is initiated by a variable number of isopropoxy groups. This number depends on both the monomer and the [monomer]/[initiator] ratio. Kinetic studies indicate that all the polymerizations are equilibrated, and the corresponding thermodynamic parameters and the equilibrium monomer concentrations have been calculated. Comprehensive kinetics carried out for e-caprolactone abd δ-valerolactone polymerizations allows the determination of kinetic order relative to both monomer and initiator concentrations, along with that of the apparent rate constants of polymerization. It is also demonstrated that propagation occurs on aggregated (δ-valerolactone) or unaggregated (e-caprolactone) active polymer chains and that the ring-opening process proceeds via [O-acyl] bond cleavages.
518 citations
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01 Jan 1984516 citations
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514 citations
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TL;DR: In this article, the first-order Raman scattering intensity in terms of the vibrational density of states of a single graphite layer weighted by the electron-phonon couping of the modes to the electromagnetic radiation is derived.
512 citations
Authors
Showing all 28995 results
Name | H-index | Papers | Citations |
---|---|---|---|
Nicholas G. Martin | 192 | 1770 | 161952 |
George F. Koob | 171 | 935 | 112521 |
Daniel J. Jacob | 162 | 656 | 76530 |
Arthur W. Toga | 159 | 1184 | 109343 |
James M. Tour | 143 | 859 | 91364 |
Floyd E. Bloom | 139 | 616 | 72641 |
Herbert Y. Meltzer | 137 | 1148 | 81371 |
Jean-Marie Tarascon | 136 | 853 | 137673 |
Stanley Nattel | 132 | 778 | 65700 |
Michel Haïssaguerre | 117 | 757 | 62284 |
Liquan Chen | 111 | 689 | 44229 |
Marion Leboyer | 110 | 773 | 50767 |
Jean-François Dartigues | 106 | 631 | 46682 |
Alexa S. Beiser | 106 | 366 | 47457 |
Robert Dantzer | 105 | 497 | 46554 |