University of Geneva

About: University of Geneva is a education organization based out in Geneva, Switzerland. It is known for research contribution in the topics: Population & Galaxy. The organization has 26887 authors who have published 65265 publications receiving 2931373 citations. The organization is also known as: Geneva University & Universite de Geneve.

The Fibronectin Domain ED-A Is Crucial for Myofibroblastic Phenotype Induction by Transforming Growth Factor-β1

Abstract: Transforming growth factor-β1 (TGFβ1), a major promoter of myofibroblast differentiation, induces α-smooth muscle (sn) actin, modulates the expression of adhesive receptors, and enhances the synthesis of extracellular matrix (ECM) molecules including ED-A fibronectin (FN), an isoform de novo expressed during wound healing and fibrotic changes We report here that ED-A FN deposition precedes α-SM actin expression by fibroblasts during granulation tissue evolution in vivo and after TGFβ1 stimulation in vitro Moreover, there is a correlation between in vitro expression of α-SM actin and ED-A FN in different fibroblastic populations Seeding fibroblasts on ED-A FN does not elicit per se α-SM actin expression; however, incubation of fibroblasts with the anti-ED-A monoclonal antibody IST-9 specifically blocks the TGFβ1-triggered enhancement of α-SM actin and collagen type I, but not that of plasminogen activator inhibitor-1 mRNA Interestingly, the same inhibiting action is exerted by the soluble recombinant domain ED-A, but neither of these inhibitory agents alter FN matrix assembly Our findings indicate that ED-A–containing polymerized FN is necessary for the induction of the myofibroblastic phenotype by TGFβ1 and identify a hitherto unknown mechanism of cytokine-determined gene stimulation based on the generation of an ECM-derived permissive outside in signaling, under the control of the cytokine itself

Enantioselective Copper-Catalyzed Conjugate Addition and Allylic Substitution Reactions

Abstract: Departament of Organic Chemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneve 4, Switzerland, Department of Organic Chemistry, Stockholm University, Arrhenius Laboratoriet, 106 91 Stockholm, Sweden, Organic Chemistry II, Dormund University of Technology, Otto-Hahn-Strasse 6, D-44227 Dortmund, Germany, and Departament de Quimica Fisica i Inorganica, Universitat Rovira i Virgili, C/ Marcel · li Domingo s/n, 43007 Tarragona, Spain

Bell inequalities for arbitrarily high dimensional systems

Abstract: We develop a novel approach to Bell inequalities based on a constraint that the correlations exhibited by local variable theories must satisfy. This is used to construct a family of Bell inequalities for bipartite quantum systems of arbitrarily high dimensionality which are strongly resistant to noise. In particular, our work gives an analytic description of previous numerical results and generalizes them to arbitrarily high dimensionality.

The social development of the intellect

Abstract: Why and how do children of the human species become intelligent, at least generally, during the first years of their existence? In the first part of this paper, we would like to show how the response to this question has been formulated in terms of social psychology, but without applying social psychological investigative methods to explicate the response. As it were, the social role in cognitive development is frequently accepted as a postulate. In the second part of this chapter, we would like to show that psychological experimentation permits illustrating, if not verifying, some characteristics of the manner in which social factors intervene in cognitive development.