Institution
University of Geneva
Education•Geneva, Switzerland•
About: University of Geneva is a education organization based out in Geneva, Switzerland. It is known for research contribution in the topics: Population & Galaxy. The organization has 26887 authors who have published 65265 publications receiving 2931373 citations. The organization is also known as: Geneva University & Universite de Geneve.
Topics: Population, Galaxy, Planet, Stars, Context (language use)
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TL;DR: The structure and function of mammalian proteins are summarized which are essential components of the constitutive splicing machinery and which exert auxiliary functions in the recognition, selection, and juxtaposition of the splice sites and drive conformational changes during spliceosome assembly and catalysis.
Abstract: Intervening sequences are removed from nuclear pre-mRNAs in a well-defined multi-step pathway. Small nuclear ribonucleoprotein particles (snRNPs) and numerous protein factors are essential for the formation of the active spliceosome in which intron excision proceeds in two successive transesterification reactions. Important elements for catalysis are the RNA moieties of the snRNPs that align the pre-mRNA splice sites in the active center of the spliceosome. Although pre-mRNA splicing is almost certainly RNA-mediated, both snRNA-associated proteins and non-snRNP splicing factors participate in each step of the splicing reaction. Splicing proteins exert auxiliary functions in the recognition, selection, and juxtaposition of the splice sites and drive conformational changes during spliceosome assembly and catalysis. Many splicing factors have been isolated in recent years and corresponding cDNAs have been cloned. This review summarizes the structure and function of mammalian proteins which are essential comp...
698 citations
TL;DR: The methodology and results of the 2007 Pediatric PDC are described, and a summary of all ISCD Official Positions is described, including the ones recently adopted by this 2007 Pediatrics PDC and the 2007 Lansdowne, Virginia, USA Adult PDC.
697 citations
Massachusetts Institute of Technology1, Harvard University2, University College London3, University of Hong Kong4, Aix-Marseille University5, University of Geneva6, University of Antioquia7, National Scientific and Technical Research Council8, University of Buenos Aires9, Universidade Federal do Rio Grande do Sul10, Federal University of Paraná11, National Autonomous University of Mexico12, Mexican Social Security Institute13, Instituto Politécnico Nacional14, Nestlé15, Universidad Autónoma de Nuevo León16, University of Santiago de Compostela17, Cayetano Heredia University18, University of Chicago19, Russian Academy of Sciences20, Université de Montréal21, University of Costa Rica22, Swiss Institute of Bioinformatics23, University of Bern24, University of Tarapacá25, Paul Sabatier University26, University of California, Berkeley27, Yale University28, Semel Institute for Neuroscience and Human Behavior29
TL;DR: It is shown that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America.
Abstract: The peopling of the Americas has been the subject of extensive genetic, archaeological and linguistic research; however, central questions remain unresolved. One contentious issue is whether the settlement occurred by means of a single migration or multiple streams of migration from Siberia. The pattern of dispersals within the Americas is also poorly understood. To address these questions at a higher resolution than was previously possible, we assembled data from 52 Native American and 17 Siberian groups genotyped at 364,470 single nucleotide polymorphisms. Here we show that Native Americans descend from at least three streams of Asian gene flow. Most descend entirely from a single ancestral population that we call 'First American'. However, speakers of Eskimo-Aleut languages from the Arctic inherit almost half their ancestry from a second stream of Asian gene flow, and the Na-Dene-speaking Chipewyan from Canada inherit roughly one-tenth of their ancestry from a third stream. We show that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America. A major exception is in Chibchan speakers on both sides of the Panama isthmus, who have ancestry from both North and South America.
696 citations
25 Aug 2013
TL;DR: The INTERSPEECH 2013 Computational Paralinguistics Challenge provides for the first time a unified test-bed for Social Signals such as laughter in speech and introduces conflict in group discussions as a new task and deals with autism and its manifestations in speech.
Abstract: The INTERSPEECH 2013 Computational Paralinguistics Challenge provides for the first time a unified test-bed for Social Signals such as laughter in speech. It further introduces conflict in group discussions as a new task and deals with autism and its manifestations in speech. Finally, emotion is revisited as task, albeit with a broader range of overall twelve enacted emotional states. In this paper, we describe these four Sub-Challenges, their conditions, baselines, and a new feature set by the openSMILE toolkit, provided to the participants. Index Terms: Computational Paralinguistics, Challenge, Social Signals, Conflict, Emotion, Autism
694 citations
European Southern Observatory1, University of Lisbon2, University of Porto3, Max Planck Society4, University of Grenoble5, University of Geneva6, Paris Diderot University7, Leiden University8, University of Cologne9, Dublin Institute for Advanced Studies10, University of California, Berkeley11, Space Telescope Science Institute12
TL;DR: Eisenhauer et al. as mentioned in this paper detect the combined gravitational redshift and relativistic transverse Doppler effect for S2 of z = Δλ / λ ≈ 200 km s−1/c with different statistical analysis methods.
Abstract: The highly elliptical, 16-year-period orbit of the star S2 around the massive black hole candidate Sgr A✻ is a sensitive probe of the gravitational field in the Galactic centre. Near pericentre at 120 AU ≈ 1400 Schwarzschild radii, the star has an orbital speed of ≈7650 km s−1, such that the first-order effects of Special and General Relativity have now become detectable with current capabilities. Over the past 26 years, we have monitored the radial velocity and motion on the sky of S2, mainly with the SINFONI and NACO adaptive optics instruments on the ESO Very Large Telescope, and since 2016 and leading up to the pericentre approach in May 2018, with the four-telescope interferometric beam-combiner instrument GRAVITY. From data up to and including pericentre, we robustly detect the combined gravitational redshift and relativistic transverse Doppler effect for S2 of z = Δλ / λ ≈ 200 km s−1/c with different statistical analysis methods. When parameterising the post-Newtonian contribution from these effects by a factor f , with f = 0 and f = 1 corresponding to the Newtonian and general relativistic limits, respectively, we find from posterior fitting with different weighting schemes f = 0.90 ± 0.09|stat ± 0.15|sys. The S2 data are inconsistent with pure Newtonian dynamics.Key words: Galaxy: center / gravitation / black hole physics⋆ This paper is dedicated to Tal Alexander, who passed away about a week before the pericentre approach of S2.⋆⋆ GRAVITY is developed in a collaboration by the Max Planck Institute for extraterrestrial Physics, LESIA of Paris Observatory/CNRS/Sorbonne Universite/Univ. Paris Diderot and IPAG of Universite Grenoble Alpes/CNRS, the Max Planck Institute for Astronomy, the University of Cologne, the CENTRA – Centro de Astrofisica e Gravitacao, and the European Southern Observatory.⋆⋆⋆ Corresponding author: F. Eisenhauer e-mail: eisenhau@mpe.mpg.de
693 citations
Authors
Showing all 27203 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| JoAnn E. Manson | 270 | 1819 | 258509 |
| Joseph L. Goldstein | 207 | 556 | 149527 |
| Kari Stefansson | 206 | 794 | 174819 |
| David Baltimore | 203 | 876 | 162955 |
| Mark I. McCarthy | 200 | 1028 | 187898 |
| Michael S. Brown | 185 | 422 | 123723 |
| Yang Gao | 168 | 2047 | 146301 |
| Napoleone Ferrara | 167 | 494 | 140647 |
| Marc Weber | 167 | 2716 | 153502 |
| Alessandro Melchiorri | 151 | 674 | 116384 |
| Andrew D. Hamilton | 151 | 1334 | 105439 |
| David P. Strachan | 143 | 472 | 105256 |
| Andrew Beretvas | 141 | 1985 | 110059 |
| Rainer Wallny | 141 | 1661 | 105387 |
| Josh Moss | 139 | 1019 | 89255 |