Institution
University of Geneva
Education•Geneva, Switzerland•
About: University of Geneva is a education organization based out in Geneva, Switzerland. It is known for research contribution in the topics: Population & Galaxy. The organization has 26887 authors who have published 65265 publications receiving 2931373 citations. The organization is also known as: Geneva University & Universite de Geneve.
Topics: Population, Galaxy, Planet, Stars, Context (language use)
Papers published on a yearly basis
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TL;DR: This work discusses quantum cryptographic protocols based on the transmission of weak coherent states and presents a system, based on a symbiosis of two existing systems, for which the information available to the eavesdropper is significantly reduced and is therefore safer than the two previous ones.
Abstract: The safety of a quantum key distribution system relies on the fact that any eavesdropping attempt on the quantum channel creates errors in the transmission. For a given error rate, the amount of information that may have leaked to the eavesdropper depends on both the particular system and the eavesdropping strategy. In this work, we discuss quantum cryptographic protocols based on the transmission of weak coherent states and present a system, based on a symbiosis of two existing systems, for which the information available to the eavesdropper is significantly reduced. This system is therefore safer than the two previous ones. We also suggest a possible experimental implementation.
500 citations
TL;DR: Several lines of evidence are presented that establish the identity of SC1 as topoisomerase II as well as some micrographs of histone-depleted chromosomes that provide evidence of the substructural organization of the scaffold.
500 citations
TL;DR: In this article, the authors reported the detection of two new multiple planet systems orbiting solar-like stars HD 47 186 and HD 181 433, which increased to 20 the number of close-in low-mass exoplanets (below 0.1 M JUP) and strengthen the fact that 80% of these planets are in multiple planetary systems.
Abstract: We report on the detection of two new multiple planet systems orbiting solar-like stars HD 47 186 and HD 181 433. The first system contains a hot Neptune of 22.78 M ⊕ with a 4.08-day period and a Saturn of 0.35 M JUP with a 3.7-year period. The second system contains a Super-Earth of 7.5 M ⊕ with a 9.4-day period, a 0.64 M JUP with a 2.6-year period, and a third companion of 0.54 M JUP with a period of about 6 years. These detections increase to 20 the number of close-in low-mass exoplanets (below 0.1 M JUP) and strengthen the fact that 80% of these planets are in multiple planetary systems.
500 citations
TL;DR: The results suggest a sequential mode of COPII and COPI action and indicate that the transport complexes are ER-to-Golgi transport intermediates from which COPI may be involved in recycling material to the ER.
500 citations
Georgia Institute of Technology1, Leipzig University2, Johns Hopkins University3, University of Cambridge4, University of Tartu5, Ontario Institute for Cancer Research6, University of Washington7, VU University Amsterdam8, University of Chicago9, Greifswald University Hospital10, University of Bristol11, Erasmus University Rotterdam12, University of Exeter13, University of Lausanne14, University of Geneva15, Swiss Institute of Bioinformatics16, University of Helsinki17, Weizmann Institute of Science18, Agency for Science, Technology and Research19, University of Queensland20, Leiden University Medical Center21, University of Liège22, University of Oxford23, University of Tampere24, Stanford University25, Turku University Hospital26, Maastricht University Medical Centre27, Karolinska Institutet28, Radboud University Nijmegen29, Utrecht University30, European Bioinformatics Institute31
TL;DR: It is observed that cis-eQTLs can be detected for 88% of the studied genes, but that they have a different genetic architecture compared to disease-associated variants, limiting the ability to use cis- eZTLs to pinpoint causal genes within susceptibility loci.
Abstract: While many disease-associated variants have been identified through genome-wide association studies, their downstream molecular consequences remain unclear. To identify these effects, we performed cis- and trans-expression quantitative trait locus (eQTL) analysis in blood from 31,684 individuals through the eQTLGen Consortium. We observed that cis-eQTLs can be detected for 88% of the studied genes, but that they have a different genetic architecture compared to disease-associated variants, limiting our ability to use cis-eQTLs to pinpoint causal genes within susceptibility loci. In contrast, trans-eQTLs (detected for 37% of 10,317 studied trait-associated variants) were more informative. Multiple unlinked variants, associated to the same complex trait, often converged on trans-genes that are known to play central roles in disease etiology. We observed the same when ascertaining the effect of polygenic scores calculated for 1,263 genome-wide association study (GWAS) traits. Expression levels of 13% of the studied genes correlated with polygenic scores, and many resulting genes are known to drive these traits.
500 citations
Authors
Showing all 27203 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| JoAnn E. Manson | 270 | 1819 | 258509 |
| Joseph L. Goldstein | 207 | 556 | 149527 |
| Kari Stefansson | 206 | 794 | 174819 |
| David Baltimore | 203 | 876 | 162955 |
| Mark I. McCarthy | 200 | 1028 | 187898 |
| Michael S. Brown | 185 | 422 | 123723 |
| Yang Gao | 168 | 2047 | 146301 |
| Napoleone Ferrara | 167 | 494 | 140647 |
| Marc Weber | 167 | 2716 | 153502 |
| Alessandro Melchiorri | 151 | 674 | 116384 |
| Andrew D. Hamilton | 151 | 1334 | 105439 |
| David P. Strachan | 143 | 472 | 105256 |
| Andrew Beretvas | 141 | 1985 | 110059 |
| Rainer Wallny | 141 | 1661 | 105387 |
| Josh Moss | 139 | 1019 | 89255 |