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Institution

University of Guelph

EducationGuelph, Ontario, Canada
About: University of Guelph is a education organization based out in Guelph, Ontario, Canada. It is known for research contribution in the topics: Population & Gene. The organization has 26542 authors who have published 50553 publications receiving 1715255 citations. The organization is also known as: U of G & Guelph University.


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Journal ArticleDOI
TL;DR: Biological activities of proteins and peptides derived from egg components, including novel antimicrobial activities, antiadhesive properties, immunomodulatory, anticancer, and antihypertensive activities, antioxidant properties, protease inhibitors, nutrient bioavailability, and functional lipids are reviewed.
Abstract: The avian egg is an important source of nutrients, containing all of the proteins, lipids, vitamins, minerals, and growth factors required by the developing embryo, as well as a number of defense factors to protect against bacterial and viral infection. Moreover, eggs are now understood to contain substances with biological functions beyond basic nutrition, and extensive research has been undertaken to identify and characterize these biologically active components. This review mainly focused on biological activities of proteins and peptides derived from egg components. Several biological activities have now been associated with egg components, including novel antimicrobial activities, antiadhesive properties, immunomodulatory, anticancer, and antihypertensive activities, antioxidant properties, protease inhibitors, nutrient bioavailability, and functional lipids, highlighting the importance of egg and egg components in human health and in disease prevention and treatment. Continued research to identify new and existing biological functions of hen egg components will help to define new methods to further improve the value of eggs as a source of numerous biologically active compounds with specific benefits for human and animal health and secure their role in the therapy and prevention of chronic and infectious disease.

417 citations

Journal ArticleDOI
Sean Walkowiak1, Sean Walkowiak2, Liangliang Gao3, Cécile Monat4, Georg Haberer, Mulualem T. Kassa5, Jemima Brinton6, Ricardo H. Ramirez-Gonzalez6, Markus C. Kolodziej7, Emily Delorean3, Dinushika Thambugala8, Valentyna Klymiuk2, Brook Byrns2, Heidrun Gundlach, Venkat Bandi2, Jorge Nunez Siri2, Kirby T. Nilsen2, Catharine Aquino, Axel Himmelbach4, Dario Copetti7, Dario Copetti9, Tomohiro Ban10, Luca Venturini11, Michael W. Bevan6, Bernardo J. Clavijo6, Dal-Hoe Koo3, Jennifer Ens2, Krystalee Wiebe2, Amidou N’Diaye2, Allen K. Fritz3, Carl Gutwin2, Anne Fiebig4, Christine Fosker6, Bin Xiao Fu1, Gonzalo Garcia Accinelli6, Keith A. Gardner, Nick Fradgley, Juan J. Gutierrez-Gonzalez12, Gwyneth Halstead-Nussloch7, Masaomi Hatakeyama7, Chu Shin Koh2, Jasline Deek13, Alejandro C. Costamagna14, Pierre R. Fobert5, Darren Heavens6, Hiroyuki Kanamori, Kanako Kawaura10, Fuminori Kobayashi, Ksenia V. Krasileva6, Tony Kuo15, Tony Kuo16, Neil McKenzie6, Kazuki Murata17, Yusuke Nabeka17, Timothy Paape7, Sudharsan Padmarasu4, Lawrence Percival-Alwyn, Sateesh Kagale5, Uwe Scholz4, Jun Sese16, Philomin Juliana18, Ravi P. Singh18, Rie Shimizu-Inatsugi7, David Swarbreck6, James Cockram, Hikmet Budak, Toshiaki Tameshige10, Tsuyoshi Tanaka, Hiroyuki Tsuji10, Jonathan M. Wright6, Jianzhong Wu, Burkhard Steuernagel6, Ian Small19, Sylvie Cloutier8, Gabriel Keeble-Gagnère, Gary J. Muehlbauer12, Josquin Tibbets, Shuhei Nasuda17, Joanna Melonek19, Pierre Hucl2, Andrew G. Sharpe2, Matthew D. Clark11, Erik Legg20, Arvind K. Bharti20, Peter Langridge21, Anthony Hall6, Cristobal Uauy6, Martin Mascher4, Simon G. Krattinger7, Simon G. Krattinger22, Hirokazu Handa23, Kentaro Shimizu7, Kentaro Shimizu10, Assaf Distelfeld24, Kenneth J. Chalmers21, Beat Keller7, Klaus F. X. Mayer25, Jesse Poland3, Nils Stein4, Nils Stein26, Curt A. McCartney8, Manuel Spannagl, Thomas Wicker7, Curtis J. Pozniak2 
25 Nov 2020-Nature
TL;DR: Comparative analysis of multiple genome assemblies from wheat reveals extensive diversity that results from the complex breeding history of wheat and provides a basis for further potential improvements to this important food crop.
Abstract: Advances in genomics have expedited the improvement of several agriculturally important crops but similar efforts in wheat (Triticum spp.) have been more challenging. This is largely owing to the size and complexity of the wheat genome1, and the lack of genome-assembly data for multiple wheat lines2,3. Here we generated ten chromosome pseudomolecule and five scaffold assemblies of hexaploid wheat to explore the genomic diversity among wheat lines from global breeding programs. Comparative analysis revealed extensive structural rearrangements, introgressions from wild relatives and differences in gene content resulting from complex breeding histories aimed at improving adaptation to diverse environments, grain yield and quality, and resistance to stresses4,5. We provide examples outlining the utility of these genomes, including a detailed multi-genome-derived nucleotide-binding leucine-rich repeat protein repertoire involved in disease resistance and the characterization of Sm16, a gene associated with insect resistance. These genome assemblies will provide a basis for functional gene discovery and breeding to deliver the next generation of modern wheat cultivars.

416 citations

Journal ArticleDOI
TL;DR: In this article, the impact of drying-rewetting events and thawing of frozen soils on larger scale ecosystem fluxes is increasingly recognized, and a growing number of studies show that these events affect fluxes of soil gases such as carbon dioxide (CO2), methane (CH4), nitrous oxide (N2O), ammonia (NH3) and nitric oxide (NO).
Abstract: . The rewetting of dry soils and the thawing of frozen soils are short-term, transitional phenomena in terms of hydrology and the thermodynamics of soil systems. The impact of these short-term phenomena on larger scale ecosystem fluxes is increasingly recognized, and a growing number of studies show that these events affect fluxes of soil gases such as carbon dioxide (CO2), methane (CH4), nitrous oxide (N2O), ammonia (NH3) and nitric oxide (NO). Global climate models predict that future climatic change is likely to alter the frequency and intensity of drying-rewetting events and thawing of frozen soils. These future scenarios highlight the importance of understanding how rewetting and thawing will influence dynamics of these soil gases. This study summarizes findings using a new database containing 338 studies conducted from 1956 to 2011, and highlights open research questions. The database revealed conflicting results following rewetting and thawing in various terrestrial ecosystems and among soil gases, ranging from large increases in fluxes to non-significant changes. Studies reporting lower gas fluxes before rewetting tended to find higher post-rewetting fluxes for CO2, N2O and NO; in addition, increases in N2O flux following thawing were greater in warmer climate regions. We discuss possible mechanisms and controls that regulate flux responses, and recommend that a high temporal resolution of flux measurements is critical to capture rapid changes in gas fluxes after these soil perturbations. Finally, we propose that future studies should investigate the interactions between biological (i.e., microbial community and gas production) and physical (i.e., porosity, diffusivity, dissolution) changes in soil gas fluxes, apply techniques to capture rapid changes (i.e., automated measurements), and explore synergistic experimental and modelling approaches.

416 citations

Book ChapterDOI
TL;DR: The chapter discusses the functional aspects of walls that include (1) interaction with metals; (2) β-lactam drugs and low-level antibiotic resistance; and (3) functional discontinuities in the wall fabric.
Abstract: Publisher Summary This chapter describes the ultrastructure, chemistry and function of the bacterial wall. Cell walls are dynamic and change to fulfill functions dictated by the cell in response to the environment. Most bacteria respond unequivocally to the Gram reaction; that is, some retain the large crystal violet-iodine complex (Gram-positive), whereas others are decolorized by the alcohol treatment (Gram-negative) and can be counterstained. Cell age, autolysin levels, and growth conditions can affect the Gram reaction. Unlike Gram-positive bacteria, freeze-cleaved and -etched Gram-negative cells present a number of cleavage sites within the wall that is an indication of multilayering. This wall is chemically and structurally more complex than its Gram-positive counterpart. Each of the layers of capsule, slime layers, and surface arrays reside above the wall and may be singular or in combination with one another. Each presents unique problems for preservation and visualization by electron microscopy. The chapter also discusses the functional aspects of walls that include (1) interaction with metals; (2) β-lactam drugs and low-level antibiotic resistance; and (3) functional discontinuities in the wall fabric.

414 citations

Journal ArticleDOI
TL;DR: This work draws together research from several disciplines to understand the relationship between animal memory and movement processes, and frames the problem in terms of the characteristics, costs and benefits of memory as outlined in psychology and neuroscience.
Abstract: Memory is critical to understanding animal movement but has proven challenging to study. Advances in animal tracking technology, theoretical movement models and cognitive sciences have facilitated research in each of these fields, but also created a need for synthetic examination of the linkages between memory and animal movement. Here, we draw together research from several disciplines to understand the relationship between animal memory and movement processes. First, we frame the problem in terms of the characteristics, costs and benefits of memory as outlined in psychology and neuroscience. Next, we provide an overview of the theories and conceptual frameworks that have emerged from behavioural ecology and animal cognition. Third, we turn to movement ecology and summarise recent, rapid developments in the types and quantities of available movement data, and in the statistical measures applicable to such data. Fourth, we discuss the advantages and interrelationships of diverse modelling approaches that have been used to explore the memory–movement interface. Finally, we outline key research challenges for the memory and movement communities, focusing on data needs and mathematical and computational challenges. We conclude with a roadmap for future work in this area, outlining axes along which focused research should yield rapid progress.

413 citations


Authors

Showing all 26778 results

NameH-indexPapersCitations
Dirk Inzé14964774468
Norbert Perrimon13861073505
Bobby Samir Acharya1331121100545
Eduardo Marbán12957949586
Benoît Roux12049362215
Fereidoon Shahidi11995157796
Stephen Safe11678460588
Mark A. Tarnopolsky11564442501
Robert C. Haddon11257752712
Milton H. Saier11170754496
Hans J. Vogel111126062846
Paul D. N. Hebert11153766288
Peter T. Katzmarzyk11061856484
John Campbell107115056067
Linda F. Nazar10631852092
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202368
2022391
20212,575
20202,547
20192,264
20182,155