Institution
University of Guelph
Education•Guelph, Ontario, Canada•
About: University of Guelph is a education organization based out in Guelph, Ontario, Canada. It is known for research contribution in the topics: Population & Gene. The organization has 26542 authors who have published 50553 publications receiving 1715255 citations. The organization is also known as: U of G & Guelph University.
Topics: Population, Gene, Context (language use), Poison control, Soil water
Papers published on a yearly basis
Papers
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Michigan State University1, National Institutes of Health2, Amgen3, University of Guelph4, Charles River Laboratories5, University of Florida6, University of Pennsylvania7, University of Georgia8, Bristol-Myers Squibb9, Purdue University10, Armed Forces Institute of Pathology11, Utrecht University12, University of Wyoming13, Royal Veterinary College14, Ohio State University15, Charles Sturt University16
TL;DR: According to the novel grading system, high-grade MCTs were significantly associated with shorter time to metastasis or new tumor development, and with shorter survival time.
Abstract: Currently, prognostic and therapeutic determinations for canine cutaneous mast cell tumors (MCTs) are primarily based on histologic grade. However, the use of different grading systems by veterinary pathologists and institutional modifications make the prognostic value of histologic grading highly questionable. To evaluate the consistency of microscopic grading among veterinary pathologists and the prognostic significance of the Patnaik grading system, 95 cutaneous MCTs from 95 dogs were graded in a blinded study by 28 veterinary pathologists from 16 institutions. Concordance among veterinary pathologists was 75% for the diagnosis of grade 3 MCTs and less than 64% for the diagnosis of grade 1 and 2 MCTs. To improve concordance among pathologists and to provide better prognostic significance, a 2-tier histologic grading system was devised. The diagnosis of high-grade MCTs is based on the presence of any one of the following criteria: at least 7 mitotic figures in 10 high-power fields (hpf); at least 3 multinucleated (3 or more nuclei) cells in 10 hpf; at least 3 bizarre nuclei in 10 hpf; karyomegaly (ie, nuclear diameters of at least 10% of neoplastic cells vary by at least two-fold). Fields with the highest mitotic activity or with the highest degree of anisokaryosis were selected to assess the different parameters. According to the novel grading system, high-grade MCTs were significantly associated with shorter time to metastasis or new tumor development, and with shorter survival time. The median survival time was less than 4 months for high-grade MCTs but more than 2 years for low-grade MCTs.
398 citations
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TL;DR: The results showed that chromate reduction by CRB5 was mediated by a soluble enzyme that was largely contained in the cytoplasm but also found outside of the cells, and may account for anaerobic reduction of chromate under nongrowth conditions with an organic electron donor present.
Abstract: A pseudomonad (CRB5) isolated from a decommissioned wood preservation site reduced toxic chromate [Cr(VI)] to an insoluble Cr(III) precipitate under aerobic and anaerobic conditions. CRB5 tolerated up to 520 mg of Cr(VI) liter(-1) and reduced chromate in the presence of copper and arsenate. Under anaerobic conditions it also reduced Co(III) and U(VI), partially internalizing each metal. Metal precipitates were also found on the surface of the outer membrane and (sometimes) on a capsule. The results showed that chromate reduction by CRB5 was mediated by a soluble enzyme that was largely contained in the cytoplasm but also found outside of the cells. The crude reductase activity in the soluble fraction showed a K(m) of 23 mg liter(-1) (437 microM) and a V(max) of 0.98 mg of Cr h(-1) mg of protein(-1) (317 nmol min(-1) mg of protein(-1)). Minor membrane-associated Cr(VI) reduction under anaerobiosis may account for anaerobic reduction of chromate under nongrowth conditions with an organic electron donor present. Chromate reduction under both aerobic and anaerobic conditions may be a detoxification strategy for the bacterium which could be exploited to bioremediate chromate-contaminated or other toxic heavy metal-contaminated environments.
397 citations
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Laurentian University1, Queen's University2, University of Texas at Austin3, University of Pennsylvania4, Carleton University5, University of Alberta6, Lawrence Berkeley National Laboratory7, University of Guelph8, University of Oxford9, University of Washington10, Los Alamos National Laboratory11, Massachusetts Institute of Technology12, Louisiana State University13, Brookhaven National Laboratory14, University of British Columbia15, TRIUMF16
TL;DR: In this paper, a combined analysis of solar neutrino data from all phases of the Sudbury Neutrino Observatory was presented, which showed that particle identification information obtained from the proportional counters installed during the third phase improved background rejection in that phase of the experiment.
Abstract: We report results from a combined analysis of solar neutrino data from all phases of the Sudbury Neutrino Observatory. By exploiting particle identification information obtained from the proportional counters installed during the third phase, this analysis improved background rejection in that phase of the experiment. The combined analysis resulted in a total flux of active neutrino flavors from 8B decays in the Sun of (5.25 \pm 0.16(stat.)+0.11-0.13(syst.))\times10^6 cm^{-2}s^{-1}. A two-flavor neutrino oscillation analysis yielded \Deltam^2_{21} = (5.6^{+1.9}_{-1.4})\times10^{-5} eV^2 and tan^2{\theta}_{12}= 0.427^{+0.033}_{-0.029}. A three-flavor neutrino oscillation analysis combining this result with results of all other solar neutrino experiments and the KamLAND experiment yielded \Deltam^2_{21} = (7.41^{+0.21}_{-0.19})\times10^{-5} eV^2, tan^2{\theta}_{12} = 0.446^{+0.030}_{-0.029}, and sin^2{\theta}_{13} =(2.5^{+1.8}_{-1.5})\times10^{-2}. This implied an upper bound of sin^2{\theta}_{13} < 0.053 at the 95% confidence level (C.L.).
397 citations
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01 Feb 2004TL;DR: A novel neural network approach is proposed for complete coverage path planning with obstacle avoidance of cleaning robots in nonstationary environments and results show that the proposed model is capable of planning collision-free complete coverage robot paths.
Abstract: Complete coverage path planning requires the robot path to cover every part of the workspace, which is an essential issue in cleaning robots and many other robotic applications such as vacuum robots, painter robots, land mine detectors, lawn mowers, automated harvesters, and window cleaners. In this paper, a novel neural network approach is proposed for complete coverage path planning with obstacle avoidance of cleaning robots in nonstationary environments. The dynamics of each neuron in the topologically organized neural network is characterized by a shunting equation derived from Hodgkin and Huxley's (1952) membrane equation. There are only local lateral connections among neurons. The robot path is autonomously generated from the dynamic activity landscape of the neural network and the previous robot location. The proposed model algorithm is computationally simple. Simulation results show that the proposed model is capable of planning collision-free complete coverage robot paths.
397 citations
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VU University Amsterdam1, Erasmus University Rotterdam2, University of Zurich3, Harvard University4, Hospital for Special Surgery5, Cornell University6, University of Amsterdam7, University of Toronto8, University of Copenhagen9, Statens Serum Institut10, University of Queensland11, University of Essex12, ETH Zurich13, Broad Institute14, University of Oxford15, Max Planck Society16, German Institute for Economic Research17, Pompeu Fabra University18, University of Edinburgh19, University of Oulu20, University of California, San Diego21, University of Lübeck22, Institut Pere Mata23, University of Colorado Boulder24, University of Konstanz25, University of North Carolina at Chapel Hill26, University of Fribourg27, Karolinska Institutet28, University of Guelph29, St. Joseph's Healthcare Hamilton30, Ludwig Maximilian University of Munich31, University of Innsbruck32, University of Cologne33, University College London34, University of Chicago35, Imperial College London36, University of Tartu37, Stockholm School of Economics38, Geisinger Health System39, Catalan Institution for Research and Advanced Studies40, University of Mainz41, University of Southern California42, Uniformed Services University of the Health Sciences43, Western General Hospital44, Translational Research Institute45, University of Minnesota46, New York University47, National Bureau of Economic Research48
TL;DR: This paper found evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of their other GWAS, and general risk-tolerance is genetically correlated with a range of risky behaviors.
Abstract: Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, including 99 loci associated with general risk tolerance. We report evidence of substantial shared genetic influences across risk tolerance and the risky behaviors: 46 of the 99 general risk tolerance loci contain a lead SNP for at least one of our other GWAS, and general risk tolerance is genetically correlated ([Formula: see text] ~ 0.25 to 0.50) with a range of risky behaviors. Bioinformatics analyses imply that genes near SNPs associated with general risk tolerance are highly expressed in brain tissues and point to a role for glutamatergic and GABAergic neurotransmission. We found no evidence of enrichment for genes previously hypothesized to relate to risk tolerance.
395 citations
Authors
Showing all 26778 results
Name | H-index | Papers | Citations |
---|---|---|---|
Dirk Inzé | 149 | 647 | 74468 |
Norbert Perrimon | 138 | 610 | 73505 |
Bobby Samir Acharya | 133 | 1121 | 100545 |
Eduardo Marbán | 129 | 579 | 49586 |
Benoît Roux | 120 | 493 | 62215 |
Fereidoon Shahidi | 119 | 951 | 57796 |
Stephen Safe | 116 | 784 | 60588 |
Mark A. Tarnopolsky | 115 | 644 | 42501 |
Robert C. Haddon | 112 | 577 | 52712 |
Milton H. Saier | 111 | 707 | 54496 |
Hans J. Vogel | 111 | 1260 | 62846 |
Paul D. N. Hebert | 111 | 537 | 66288 |
Peter T. Katzmarzyk | 110 | 618 | 56484 |
John Campbell | 107 | 1150 | 56067 |
Linda F. Nazar | 106 | 318 | 52092 |