University of Victoria

About: University of Victoria is a education organization based out in Victoria, British Columbia, Canada. It is known for research contribution in the topics: Population & Galaxy. The organization has 14994 authors who have published 41051 publications receiving 1447972 citations. The organization is also known as: Victoria College.

Origin of Mammalian Gonadotropin-Releasing Hormones

Abstract: I. Introduction GONADOTROPIN-releasing hormone (GnRH) plays a pivotal role in reproduction. The existence of this neuropeptide, also called LHRH, was predicted in the 1950s (1), but the structure of the 10 amino acid peptide for porcine and ovine brains was not reported until the 1970s (2, 3). In the 20 yr since then, only one form of GnRH has been identified in most placental mammals, and this is still considered to be the sole neuropeptide causing the release of LH and FSH. The structure and functions of the mammalian form of GnRH have been reviewed a number of times (4s–8). Meanwhile, both mammalian GnRH and related forms of GnRH are now known to be present in primitive placental mammals, nonplacental mammals, and other vertebrates. Novel functions, in addition to the release of gonadotropins, exist. Studies of GnRH peptides and their genes have altered our views on the origin, function, and regulation of this neuropeptide.

Use of models in detection and attribution of climate change

Abstract: Most detection and attribution studies use climate models to determine both the expected ‘fingerprint’ of climate change and the uncertainty in the estimated magnitude of this fingerprint in observations, given the climate variability. This review discusses the role of models in detection and attribution, the associated uncertainties, and the robustness of results. Studies that use observations only make substantial assumptions to separate the components of observed changes due to radiative forcing from those due to internal climate variability. Results from observation-only studies are broadly consistent with those from fingerprint studies. Fingerprint studies evaluate the extent to which patterns of response to external forcing (fingerprints) from climate model simulations explain observed climate change in observations. Fingerprints are based on climate models of various complexities, from energy balance models to full earth system models. Statistical approaches range from simple comparisons of observations with model simulations to multi-regression methods that estimate the contribution of several forcings to observed change using a noise-reducing metric. Multi-model methods can address model uncertainties to some extent and we discuss how remaining uncertainties can be overcome. The increasing focus on detecting and attributing regional climate change and impacts presents both opportunities and challenges. Challenges arise because internal variability is larger on smaller scales, and regionally important forcings, such as from aerosols or land-use change, are often uncertain. Nevertheless, if regional climate change can be linked to external forcing, the results can be used to provide constraints on regional climate projections.

Drought in a human-modified world : reframing drought definitions, understanding, and analysis approaches

Abstract: In the current human-modified world, or Anthropocene, the state of water stores and fluxes has become dependent on human as well as natural processes. Water deficits (or droughts) are the result of ...

Nonsuicidal self-harm in youth : a population-based survey

Abstract: Background: Nonsuicidal self-harm includes cutting, scratching, burning and minor overdosing. There have been few studies that have examined the rate of self-harm and mental-health correlates among community-based youth. We performed a population-based study to determine the prevalence of nonsuicidal self-harm, its mental-health correlates and help-seeking behaviour. Methods: We used data from the Victoria Healthy Youth Survey, a population-based longitudinal survey of youth aged 14–21 in Victoria, British Columbia. The survey included questions about the history, method, frequency, age of onset and help-seeking for nonsuicidal self-harm. Youth were interviewed between February and June 2005. Univariable group differences were analyzed using students t test for continuous data and χ 2 for binary or categorical data. Multivariate analyses were conducted by use of multivariate analysis of variance and logistic regression. Results: Ninety-six of 568 (16.9%) youth indicated that they had ever harmed themselves. Self-injuries such as cutting, scratching and self-hitting were the most common forms of nonsuicidal self-harm (83.2%). The mean age of onset was 15.2 years. Of those who reported nonsuicidal self-harm, 56% had sought help for this behaviour. Participants who reported 5 or more symptoms (out of 6) in a given symptom category were more likely than those who reported less than 5 symptoms to report nonsuicidal self-harm for the following categories: depressive mood (odds ratio [OR] 2.18, confidence interval [CI] 1.28–3.7) and problems with regulation of attention, impulsivity and activity (OR 2.24, CI 1.33–3.76). Interpretation: We found a high lifetime prevalence of nonsuicidal self-harm. Many mental-health symptoms were associated with this behaviour, particularly those with depressive mood and attention-related problems. Just over half of youth reported seeking help for nonsuicidal self-harm. Clinicians who encounter youth should be vigilant to assess for this behaviour in youth who present with mental health issues.