Institution
University of Victoria
Education•Victoria, British Columbia, Canada•
About: University of Victoria is a education organization based out in Victoria, British Columbia, Canada. It is known for research contribution in the topics: Population & Galaxy. The organization has 14994 authors who have published 41051 publications receiving 1447972 citations. The organization is also known as: Victoria College.
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TL;DR: It is concluded that FoxP3+ T cells have heterogeneous properties that can be discerned by the use of additional markers and seem to depend on the tumor site, perhaps reflecting microenvironmental differences.
Abstract: CD8+ tumor-infiltrating lymphocytes (TIL) are associated with survival in a variety of cancers. A second subpopulation of TIL, defined by forkhead box protein P3 (FoxP3) expression, has been reported to inhibit tumor immunity, resulting in decreased patient survival. On the basis of this premise, several groups are attempting to deplete FoxP3+ T cells to enhance tumor immunity. However, recent studies have challenged this paradigm by showing that FoxP3+ T cells exhibit heterogeneous phenotypes and, in some cohorts, are associated with favorable prognosis. These discrepant results could arise from differences in study methodologies or the biologic properties of specific cancer types. Here, we conduct the first systematic review of the prognostic significance of FoxP3+ T cells across nonlymphoid cancers (58 studies from 16 cancers). We assessed antibody specificity, cell-scoring strategy, multivariate modeling, use of single compared with multiple markers, and tumor site. Two factors proved important. First, when FoxP3 was combined with one additional marker, double-positive T cells were generally associated with poor prognosis. Second, tumor site had a major influence. FoxP3+ T cells were associated with poor prognosis in hepatocellular cancer and generally good prognosis in colorectal cancer, whereas other cancer types were inconsistent or understudied. We conclude that FoxP3+ T cells have heterogeneous properties that can be discerned by the use of additional markers. Furthermore, the net biologic effects of FoxP3+ T cells seem to depend on the tumor site, perhaps reflecting microenvironmental differences. Thus, depletion of FoxP3+ T cells might enhance tumor immunity in some patient groups but be detrimental in others.
399 citations
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TL;DR: In this paper, an integrative model examining the relationships among relational, structural and cognitive dimensions of social capital, and between these dimensions and the cost and innovation performance of the firm was proposed.
396 citations
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Peking University1, University of Arizona2, Leiden University3, University of Leicester4, University of Cambridge5, University of Milan6, Vassar College7, Smith College8, University of Grenoble9, University of Victoria10, Max Planck Society11, Chinese Academy of Sciences12, Rice University13, University of Paris14, European Southern Observatory15, University of Chicago16, INAF17, Space Telescope Science Institute18, Ames Research Center19
TL;DR: In this article, the authors identify the most frequently revealed substructure in ALMA dust observations of protoplanetary disks, and measure their properties to investigate how they form, including axisymmetric rings and gaps.
Abstract: Rings are the most frequently revealed substructure in ALMA dust observations of protoplanetary disks, but their origin is still hotly debated. In this paper, we identify dust substructures in 12 disks and measure their properties to investigate how they form. This subsample of disks is selected from a high-resolution ($\sim0.12''$) ALMA 1.33 mm survey of 32 disks in the Taurus star-forming region, which was designed to cover a wide range of sub-mm brightness and to be unbiased to previously known substructures. While axisymmetric rings and gaps are common within our sample, spiral patterns and high contrast azimuthal asymmetries are not detected. Fits of disk models to the visibilities lead to estimates of the location and shape of gaps and rings, the flux in each disk component, and the size of the disk. The dust substructures occur across a wide range of stellar mass and disk brightness. Disks with multiple rings tend to be more massive and more extended. The correlation between gap locations and widths, the intensity contrast between rings and gaps, and the separations of rings and gaps could all be explained if most gaps are opened by low-mass planets (super-Earths and Neptunes) in the condition of low disk turbulence ($\alpha=10^{-4}$). The gap locations are not well correlated with the expected locations of CO and N$_2$ ice lines, so condensation fronts are unlikely to be a universal mechanism to create gaps and rings, though they may play a role in some cases.
395 citations
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TL;DR: The structure of proaerolysin determined by X-ray crystallography at 2.8 Å resolution is described and it is proposed that insertion of the protein into lipid bilayers to form ion channels is accounted for.
Abstract: Aerolysin is chiefly responsible for the pathogenicity of Aeromonas hydrophila, a bacterium associated with diarrhoeal diseases and deep wound infections. Like many other microbial toxins, the protein changes in a multistep process from a completely water-soluble form to produce a transmembrane channel that destroys sensitive cells by breaking their permeability barriers. Here we describe the structure of proaerolysin determined by X-ray crystallography at 2.8 A resolution. The protoxin (M(r) 52,000) adopts a novel protein fold. Images of an aerolysin oligomer derived from electron microscopy have assisted in constructing a model of the membrane channel and have led to the proposal of a scheme to account for insertion of the protein into lipid bilayers to form ion channels.
393 citations
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TL;DR: New insights are highlighted for practice and future research that are needed to enhance the development of strategies aimed at improving the ethical climate of nurses’ workplaces for the benefit of both nurses and patients.
Abstract: Moral distress is a phenomenon of increasing concern in nursing practice, education and research. Previous research has suggested that moral distress is associated with perceptions of ethical climate, which has implications for nursing practice and patient outcomes. In this study, a randomly selected sample of registered nurses was surveyed using Corley’s Moral Distress Scale and Olson’s Hospital Ethical Climate Survey (HECS). The registered nurses reported moderate levels of moral distress intensity. Moral distress intensity and frequency were found to be inversely correlated with perceptions of ethical climate. Each of the HECS factors (peers, patients, managers, hospitals and physicians) was found to be significantly correlated with moral distress. Based on these findings, we highlight insights for practice and future research that are needed to enhance the development of strategies aimed at improving the ethical climate of nurses’ workplaces for the benefit of both nurses and patients.
391 citations
Authors
Showing all 15188 results
Name | H-index | Papers | Citations |
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Jie Zhang | 178 | 4857 | 221720 |
D. M. Strom | 176 | 3167 | 194314 |
Sw. Banerjee | 146 | 1906 | 124364 |
Robert J. Glynn | 146 | 748 | 88387 |
Manel Esteller | 146 | 713 | 96429 |
R. Kowalewski | 143 | 1815 | 135517 |
Paul Jackson | 141 | 1372 | 93464 |
Mingshui Chen | 141 | 1543 | 125369 |
Ali Khademhosseini | 140 | 887 | 76430 |
Roger Jones | 138 | 998 | 114061 |
Tord Ekelof | 137 | 1212 | 91105 |
L. Köpke | 136 | 950 | 81787 |
M. Morii | 134 | 1664 | 102074 |
Arnaud Ferrari | 134 | 1392 | 87052 |
Richard Brenner | 133 | 1108 | 87426 |