University of Zagreb

About: University of Zagreb is a education organization based out in Zagreb, Grad Zagreb, Croatia. It is known for research contribution in the topics: Population & European union. The organization has 21769 authors who have published 50267 publications receiving 783239 citations. The organization is also known as: Zagreb University & Sveučilište u Zagrebu.

Novel Cyano- and Amidino-Substituted Derivatives of Styryl-2-Benzimidazoles and Benzimidazo[1,2-a]quinolines. Synthesis, Photochemical Synthesis, DNA Binding, and Antitumor Evaluation, Part 3

Abstract: Synthesis of novel cyano- and amidino-substituted styryl-2-benzimidazoles and benzimidazo[1,2-a]quinolines by condensation reactions and photochemical dehydrocyclization and dehydrohalogenation cyclization is described. Thermal denaturation experiments reveal that cyclic derivatives considerably stabilize DNA double helix, while the effect of their acyclic analogues is negligible. According to the spectroscopic study of the interaction of cyclic derivative 19, we propose intercalation of benzimidazo[1,2-a]quinoline moiety into ct-DNA as a dominant interaction underlying biologically relevant effects of this compound, whereas for its acyclic derivative 11, we propose binding into the minor groove of DNA. All compounds show noticeable antiproliferative effect. Morpholino- and chloro-substituted compound 9 is the most active among all acyclic derivatives. All cyclic compounds were 2- to 10-fold more potent, which is correlated with their property to intercalate into DNA. The most active imidazolyl-substituted compound 19 inhibits topoisomerase II and induces strong G2/M cell cycle arrest, pointing to the impairment in mitotic progression. Its pronounced selectivity toward colon carcinoma cells encourages further development of this compound as a lead.

Sample preparation in analysis of pharmaceuticals

Abstract: Sample preparation is a very important and essential step in environmental analysis. This article presents an overview of extraction methods for environmental samples, focusing especially on pharmaceuticals as there is great concern about them as pollutants.

Combined STEREO/RHESSI Study of Coronal Mass Ejection Acceleration and Particle Acceleration in Solar Flares

Abstract: Using the potential of two unprecedented missions, Solar Terrestrial Relations Observatory (STEREO) and Reuven Ramaty High-Energy Solar Spectroscopic Imager (RHESSI), we study three well-observed fast coronal mass ejections (CMEs) that occurred close to the limb together with their associated high-energy flare emissions in terms of RHESSI hard X-ray (HXR) spectra and flux evolution. From STEREO/EUVI and STEREO/COR1 data, the full CME kinematics of the impulsive acceleration phase up to ~4 R ☉ is measured with a high time cadence of ≤2.5 minutes. For deriving CME velocity and acceleration, we apply and test a new algorithm based on regularization methods. The CME maximum acceleration is achieved at heights h ≤ 0.4 R ☉, and the peak velocity at h ≤ 2.1 R ☉ (in one case, as small as 0.5 R ☉). We find that the CME acceleration profile and the flare energy release as evidenced in the RHESSI HXR flux evolve in a synchronized manner. These results support the "standard" flare/CME model which is characterized by a feedback relationship between the large-scale CME acceleration process and the energy release in the associated flare.

ALMA Imaging of Gas and Dust in a Galaxy Protocluster at Redshift 5.3: [CII] Emission in "Typical" Galaxies and Dusty Starbursts ~1 Billion Years after the Big Bang

Abstract: We report interferometric imaging of [CII] and OH emission toward the center of the galaxy protocluster associated with the z=5.3 submillimeter galaxy (SMG) AzTEC-3, using the Atacama Large (sub)Millimeter Array (ALMA). We detect strong [CII], OH, and rest-frame 157.7 um continuum emission toward the SMG. The [CII] emission is distributed over a scale of 3.9 kpc, implying a dynamical mass of 9.7 x 10^10 Msun, and a star formation rate (SFR) surface density of Sigma_SFR = 530 Msun/yr/kpc2. This suggests that AzTEC-3 forms stars at Sigma_SFR approaching the Eddington limit for radiation pressure supported disks. We find that the OH emission is slightly blueshifted relative to the [CII] line, which may indicate a molecular outflow associated with the peak phase of the starburst. We also detect and dynamically resolve [CII] emission over a scale of 7.5 kpc toward a triplet of Lyman-break galaxies with moderate UV-based SFRs in the protocluster at ~95kpc projected distance from the SMG. These galaxies are not detected in the continuum, suggesting far-infrared SFRs of 5, showing that ALMA can detect the interstellar medium in "typical" galaxies in the very early universe.