Showing papers by "University of Zagreb published in 2020"
University of Amsterdam1, Ghent University2, University of Chicago3, University of Pennsylvania4, Lund University5, Auckland City Hospital6, University of Antwerp7, University of New South Wales8, Katholieke Universiteit Leuven9, Guy's and St Thomas' NHS Foundation Trust10, Queen's University11, University of Zagreb12, Northwestern University13, Medical University of Łódź14, University of Aberdeen15, Medical University of South Carolina16, University of North Carolina at Chapel Hill17, University of Southampton18, University of São Paulo19, National University of Singapore20, Flinders University21
TL;DR: The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012 and addresses areas not extensively covered in EPOS2012 such as paediatric CRS and sinus surgery.
Abstract: The European Position Paper on Rhinosinusitis and Nasal Polyps 2020 is the update of similar evidence based position papers published in 2005 and 2007 and 2012. The core objective of the EPOS2020 guideline is to provide revised, up-to-date and clear evidence-based recommendations and integrated care pathways in ARS and CRS. EPOS2020 provides an update on the literature published and studies undertaken in the eight years since the EPOS2012 position paper was published and addresses areas not extensively covered in EPOS2012 such as paediatric CRS and sinus surgery. EPOS2020 also involves new stakeholders, including pharmacists and patients, and addresses new target users who have become more involved in the management and treatment of rhinosinusitis since the publication of the last EPOS document, including pharmacists, nurses, specialised care givers and indeed patients themselves, who employ increasing self-management of their condition using over the counter treatments. The document provides suggestions for future research in this area and offers updated guidance for definitions and outcome measurements in research in different settings. EPOS2020 contains chapters on definitions and classification where we have defined a large number of terms and indicated preferred terms. A new classification of CRS into primary and secondary CRS and further division into localized and diffuse disease, based on anatomic distribution is proposed. There are extensive chapters on epidemiology and predisposing factors, inflammatory mechanisms, (differential) diagnosis of facial pain, allergic rhinitis, genetics, cystic fibrosis, aspirin exacerbated respiratory disease, immunodeficiencies, allergic fungal rhinosinusitis and the relationship between upper and lower airways. The chapters on paediatric acute and chronic rhinosinusitis are totally rewritten. All available evidence for the management of acute rhinosinusitis and chronic rhinosinusitis with or without nasal polyps in adults and children is systematically reviewed and integrated care pathways based on the evidence are proposed. Despite considerable increases in the amount of quality publications in recent years, a large number of practical clinical questions remain. It was agreed that the best way to address these was to conduct a Delphi exercise . The results have been integrated into the respective sections. Last but not least, advice for patients and pharmacists and a new list of research needs are included. The full document can be downloaded for free on the website of this journal: http://www.rhinologyjournal.com.
2,853 citations
TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.
Abstract: Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale1,2,3. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter4; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation5,6; analyses timings and patterns of tumour evolution7; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity8,9; and evaluates a range of more-specialized features of cancer genomes8,10,11,12,13,14,15,16,17,18.
1,600 citations
University of Texas MD Anderson Cancer Center1, University of California, Davis2, City of Hope National Medical Center3, University of Chicago4, Harvard University5, Monash University6, University of Ulm7, University of Paris8, Université catholique de Louvain9, McMaster University10, University of Barcelona11, Peking Union Medical College12, University of Zagreb13, University of Ostrava14, University of Helsinki15, University of Debrecen16, University of Genoa17, Seoul National University18, Sungkyunkwan University19, China Medical University (Taiwan)20, Ondokuz Mayıs University21, Genentech22, AbbVie23, University of Pennsylvania24
TL;DR: In previously untreated patients with confirmed AML who were ineligible for intensive chemotherapy, overall survival was longer and the incidence of remission was higher among patients who received azacitidine plus venetoclax than among those who received zsitidine alone.
Abstract: Background Older patients with acute myeloid leukemia (AML) have a dismal prognosis, even after treatment with a hypomethylating agent. Azacitidine added to venetoclax had promising effica...
1,097 citations
TL;DR: A review of green extraction techniques and their role in promoting sustainable ingredients for the food, cosmetic and pharmaceutical industries is presented in this paper, where the authors focus on the strategies and present them as success stories for research and education and at the industrial scale.
321 citations
TL;DR: In this article, a review of the status of research within the exploitation of renewable energy sources with a focus on technologies exploiting renewable energies sources, a status of the assessment of the availability of renewable Energy sources and the status on the research into the types of systems, that can integrate renewable energy source.
300 citations
TL;DR: The most widespread functional ingredients, such as polyunsaturated fatty acids, probiotics/prebiotics/synbiotics, and antioxidants, and their technological means of delivery in food products are described and a guideline to attest that some ingredients or foods truly deserve this special designation is proposed.
Abstract: Functional foods is a very popular term in the social and scientific media; consequently, food producers have invested resources in the development of processed foods that may provide added functio...
280 citations
TL;DR: The authors reviewed existing immigrant entrepreneurship literature in order to map out the major streams of research and identify widely used theories, methods, and contexts, highlighting the need for interdisciplinary approaches that transcend boundaries.
220 citations
TL;DR: Results indicate that statins could be efficient SARS-CoV-2 Mpro inhibitors, based upon the binding energy of pitavastatin, rosuvastsatin, lovastatin and fluvastatin; however, further research is necessary to investigate their potential use as drugs for COVID-19.
Abstract: introduction: No proven drug and no immunisation are yet available for COVID-19 disease. The SARS-CoV-2 main protease (Mpro), a key coronavirus enzyme, which is a potential drug target, has been successfully crystallised. There is evidence suggesting that statins exert anti-viral activity and may block the infectivity of enveloped viruses. The aim of this study was to assess whether statins are potential COVID-19 Mpro inhibitors, using a molecular docking study. Material and methods: Molecular docking was performed using AutoDock/ Vina, a computational docking program. SARS-CoV-2 Mpro was docked with all statins, while antiviral and antiretroviral drugs - favipiravir, nelfinavir, and lopinavir - were used as standards for comparison. Results: The binding energies obtained from the docking of 6LU7 with native ligand favipiravir, nelfinavir, lopinavir, simvastatin, rosuvastatin, pravastatin, pitavastatin, lovastatin, fluvastatin, and atorvastatin were -6.8, -5.8, -7.9, -7.9, -7.0, -7.7, -6.6, -8.2, -7.4, -7.7, and -6.8 kcal/mol, respectively. The number of hydrogen bonds between statins and amino acid residues of Mpro were 7, 4, and 3 for rosuvastatin, pravastatin, and atorvastatin, respectively, while other statins had two hydrogen bonds. Conclusions: These results indicate, based upon the binding energy of pitavastatin, rosuvastatin, lovastatin, and fluvastatin, that statins could be efficient SARS-CoV-2 Mpro inhibitors. This is supported by the fact that the effects of some statins, especially pitavastatin, have a binding energy that is even greater than that of protease or polymerase inhibitors. However, further research is necessary to investigate their potential use as drugs for COVID-19.
214 citations
University of Glasgow1, National University of Singapore2, University of Groningen3, The George Institute for Global Health4, Mayo Clinic5, University of Minnesota6, Novartis7, National University of Cordoba8, Baylor University Medical Center9, Harvard University10, Northwestern University11, University of Lorraine12, Medical University of South Carolina13, University of Zagreb14, Cardiovascular Institute of the South15, Semmelweis University16, Medical University of Łódź17, University of Arizona18
TL;DR: As compared with valsartan, sacubitril-valsartan seemed to reduce the risk of heart failure hospitalization more in women than in men, but the present study does not provide a definite mechanistic basis for this finding.
Abstract: Background: Unlike heart failure with reduced ejection fraction, there is no approved treatment for heart failure with preserved ejection fraction, the predominant phenotype in women. Therefore, th...
207 citations
TL;DR: In this article, a map that correlates tectonic units between Alps and western Turkey accompanied by a text providing access to literature data is presented, explaining the concepts used for defining the mapped Tectonic Units, and first-order paleogeographic inferences.
201 citations
TL;DR: Scientific evidence regarding adverse impact of diverse human disasters on mental health in afflicted groups and societies and psychosocial impact of COVID-19 as a specific global human disaster is presented, with an emphasis on disturbing mental health aspects of the ongoing pandemic.
Abstract: Deep emotional traumas in societies overwhelmed by large-scale human disasters, like, global pandemic diseases, natural disasters, man-made tragedies, war conflicts, social crises, etc., can cause massive stress-related disorders. Motivated by the ongoing global coronavirus pandemic, the article provides an overview of scientific evidence regarding adverse impact of diverse human disasters on mental health in afflicted groups and societies. Following this broader context, psychosocial impact of COVID-19 as a specific global human disaster is presented, with an emphasis on disturbing mental health aspects of the ongoing pandemic. Limited resources of mental health services in a number of countries around the world are illustrated, which will be further stretched by the forthcoming increase in demand for mental health services due to the global COVID-19 pandemic. Mental health challenges are particularly important for the Republic of Croatia in the current situation, due to disturbing stress of the 2020 Zagreb earthquake and the high pre-pandemic prevalence of chronic Homeland-War-related posttraumatic stress disorders. Comprehensive approach based on digital psychiatry is proposed to address the lack of access to psychiatric services, which includes artificial intelligence, telepsychiatry and an array of new technologies, like internet-based computer-aided mental health tools and services. These tools and means should be utilized as an important part of the whole package of measures to mitigate negative mental health effects of the global coronavirus pandemic. Our scientific and engineering experiences in the design and development of digital tools and means in mitigation of stress-related disorders and assessment of stress resilience are presented. Croatian initiative on enhancement of interdisciplinary research of psychiatrists, psychologists and computer scientists on the national and EU level is important in addressing pressing mental health concerns related to the ongoing pandemic and similar human disasters.
Emory University1, Autonomous University of Barcelona2, United States Department of Veterans Affairs3, University of Bologna4, Erasmus University Rotterdam5, New York Medical College6, University of Zagreb7, Charité8, National and Kapodistrian University of Athens9, University of Belgrade10, University of Lübeck11
TL;DR: High concentrations of fluorescent polystyrene microplastics showed more toxic effect than 100 nm PS- MPs on earthworms, and oxidative stress was induced after PS-MPs exposure, providing new insights regarding the toxicological effects of low concentrations of microplastic on earth worms, and on the ecological risks ofmicroplastics to soil animals.
TL;DR: The present guideline is the first of a new series of "practical guidelines" based on more detailed scientific guidelines produced by ESPEN, and includes flow charts that connect the individual recommendations to logical care pathways and allow rapid navigation through the guideline.
24 Apr 2020
TL;DR: Enc encouraging the athlete to reset their mindset to understand quarantine as an opportunity for development, organizing appropriate guidance, educating and encouraging athletes to apply appropriate preventive behavior and hygiene measures to promote immunity and ensuring good living isolation conditions is strongly recommended.
Abstract: In December of 2019, there was an outbreak of a severe acute respiratory syndrome caused by the Coronavirus 2 (SARS-CoV-2 or COVID-19) in China. The virus rapidly spread into the whole World causing an unprecedented pandemic and forcing governments to impose a global quarantine, entering an extreme unknown situation. The organizational consequences of quarantine/isolation are: absence of organized training and competition, lack of communication among athletes and coaches, inability to move freely, lack of adequate sunlight exposure, inappropriate training conditions. Based on the current scientific, we strongly recommend encouraging the athlete to reset their mindset to understand quarantine as an opportunity for development, organizing appropriate guidance, educating and encourage athletes to apply appropriate preventive behavior and hygiene measures to promote immunity and ensuring good living isolation conditions. The athlete’s living space should be equipped with cardio and resistance training equipment (portable bicycle or rowing ergometer). Some forms of body mass resistance circuit-based training could promote aerobic adaptation. Sports skills training should be organized based on the athlete’s needs. Personalized conditioning training should be carried out with emphasis on neuromuscular performance. Athletes should also be educated about nutrition (Vitamin D and proteins) and hydration. Strategies should be developed to control body composition. Mental fatigue should be anticipated and mental controlled. Adequate methods of recovery should be provided. Daily monitoring should be established. This is an ideal situation in which to rethink personal life, understanding the situation, that can be promoted in these difficult times that affect practically the whole world.
TL;DR: In this article, a bibliometric and systematic review classifies SME and IEs research findings into three echelons: (i) subjects; (ii) theories; and (iii) methods.
Abstract: Business is dynamic and rapidly changing. Global markets were previously the playing field of multinational corporations (MNCs), while small and medium enterprises (SMEs) were local; however, the removal of imposed barriers, and recent technological advances in manufacturing, transportation and communications have indorsed SMEs and international entrepreneurs (IE) global access. SMEs and IEs are increasingly fueling economic growth and innovation and these trends are presenting both opportunities and challenges to both MNCs and SMEs in the global arena. This review systematically examines comparative SME and IE research, analyzing (after fine tuning) 762 articles published in leading journals from 1992 to September 2018. Our bibliometric and systematic review classifies SME and IE research findings into three echelons: (i) subjects; (ii) theories; and (iii) methods.
TL;DR: In this article, the authors provide a conceptual framework for analyzing the relationships among additive manufacturing adoption, flexibility, and performance in the supply chain context, and provide insights into how supply chain flexibility mediates the effect of Additive Manufacturing adoption on supply chain performance.
TL;DR: It is suggested that MedDiet has a beneficial role on CVD prevention in populations inclusive of individuals with diabetes, and an inverse association with total CVD mortality.
Abstract: To update the clinical practice guidelines for nutrition therapy of the European Association for the Study of Diabetes, we conducted a systematic review and meta-analysis of prospective cohort studies and randomized clinical trials (RCTs) to evaluate the effect of the Mediterranean diet (MedDiet) on the prevention of cardiovascular disease (CVD) incidence and mortality. We searched Medline, EMBASE (through April 20, 2018) and Cochrane (through May 7, 2018) databases. Pooled relative risks (RRs) and 95% confidence interval (CI) were calculated by the generic inverse variance method. A total of 41 reports (3 RCTs and 38 cohorts) were included. Meta-analyses of RCTs revealed a beneficial effect of the MedDiet on total CVD incidence (RR: 0.62; 95% CI: 0.50, 0.78) and total myocardial infarction (MI) incidence (RR: 0.65; 95% CI: 0.49, 0.88). Meta-analyses of prospective cohort studies, which compared the highest versus lowest categories of MedDiet adherence, revealed an inverse association with total CVD mortality (RR: 0.79; 95% CI: 0.77, 0.82), coronary heart disease (CHD) incidence (RR: 0.73; 95% CI: 0.62, 0.86), CHD mortality (RR: 0.83; 95% CI: 0.75, 0.92), stroke incidence (RR: 0.80; 95% CI: 0.71, 0.90), stroke mortality (RR: 0.87; 95% CI: 0.80, 0.96) and MI incidence (RR: 0.73; 95% CI: 0.61, 0.88). The present study suggests that MedDiet has a beneficial role on CVD prevention in populations inclusive of individuals with diabetes.
Masaryk University1, Zurich University of Applied Sciences/ZHAW2, University of Bayreuth3, Spanish National Research Council4, Stellenbosch University5, Murdoch University6, University of Belgrade7, Sapienza University of Rome8, University of Göttingen9, University of the Basque Country10, Free University of Bozen-Bolzano11, Russian Academy of Sciences12, Martin Luther University of Halle-Wittenberg13, Slovenian Academy of Sciences and Arts14, University of Nova Gorica15, University of Novi Sad16, Research Institute for Nature and Forest17, University of Western Brittany18, National Academy of Sciences of Ukraine19, Slovak Academy of Sciences20, Complutense University of Madrid21, University of Lorraine22, University of Catania23, Transilvania University of Brașov24, University of Bremen25, University of Rostock26, Radboud University Nijmegen27, Mendel University28, University of Wrocław29, Karabük University30, Keldysh Institute of Applied Mathematics31, Kazan Federal University32, Forest Research Institute33, Centre national de la recherche scientifique34, Alexandru Ioan Cuza University35, Shirshov Institute of Oceanology36, University of Barcelona37, University of Vic38, University of Agriculture, Faisalabad39, University of Latvia40, University of Kiel41, University of Zagreb42, University of Molise43, Bulgarian Academy of Sciences44, University of Vienna45, European Environment Agency46
TL;DR: This article developed the classification expert system EUNIS-ESy, which assigns vegetation plots to European habitats based on their species composition and geographic location. But the system is not suitable for outdoor gardening.
Abstract: EUNIS Habitat Classification is a standard classification of European habitats. We developed the classification expert system EUNIS‐ESy, which assigns vegetation plots to EUNIS habitats based on their species composition and geographic location. We classified 1,261,373 vegetation plots from the European Vegetation Archive and determined characteristic species combinations and prepared distribution maps for 199 habitats at Level 3 of EUNIS hierarchy.
Ido Didi Fabian1, Ido Didi Fabian2, Elhassan Abdallah3, Shehu U. Abdullahi4 +473 more•Institutions (155)
TL;DR: This cross-sectional analysis reports the retinoblastoma stage at diagnosis across the world during a single year, investigates associations between clinical variables and national income level, and investigates risk factors for advanced disease at diagnosis.
Abstract: Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Objectives: To report the retinoblastoma stage at diagnosis in patients across the world during a single year, to investigate associations between clinical variables and national income level, and to investigate risk factors for advanced disease at diagnosis. Design, Setting, and Participants: A total of 278 retinoblastoma treatment centers were recruited from June 2017 through December 2018 to participate in a cross-sectional analysis of treatment-naive patients with retinoblastoma who were diagnosed in 2017. Main Outcomes and Measures: Age at presentation, proportion of familial history of retinoblastoma, and tumor stage and metastasis. Results: The cohort included 4351 new patients from 153 countries; the median age at diagnosis was 30.5 (interquartile range, 18.3-45.9) months, and 1976 patients (45.4%) were female. Most patients (n = 3685 [84.7%]) were from low- and middle-income countries (LMICs). Globally, the most common indication for referral was leukocoria (n = 2638 [62.8%]), followed by strabismus (n = 429 [10.2%]) and proptosis (n = 309 [7.4%]). Patients from high-income countries (HICs) were diagnosed at a median age of 14.1 months, with 656 of 666 (98.5%) patients having intraocular retinoblastoma and 2 (0.3%) having metastasis. Patients from low-income countries were diagnosed at a median age of 30.5 months, with 256 of 521 (49.1%) having extraocular retinoblastoma and 94 of 498 (18.9%) having metastasis. Lower national income level was associated with older presentation age, higher proportion of locally advanced disease and distant metastasis, and smaller proportion of familial history of retinoblastoma. Advanced disease at diagnosis was more common in LMICs even after adjusting for age (odds ratio for low-income countries vs upper-middle-income countries and HICs, 17.92 [95% CI, 12.94-24.80], and for lower-middle-income countries vs upper-middle-income countries and HICs, 5.74 [95% CI, 4.30-7.68]). Conclusions and Relevance: This study is estimated to have included more than half of all new retinoblastoma cases worldwide in 2017. Children from LMICs, where the main global retinoblastoma burden lies, presented at an older age with more advanced disease and demonstrated a smaller proportion of familial history of retinoblastoma, likely because many do not reach a childbearing age. Given that retinoblastoma is curable, these data are concerning and mandate intervention at national and international levels. Further studies are needed to investigate factors, other than age at presentation, that may be associated with advanced disease in LMICs.
TL;DR: All of the latest and most important research in basic sciences, pathogenesis, and non-operative treatment of osteoarthritis is summarized.
Abstract: Being the most common musculoskeletal progressive condition, osteoarthritis is an interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) among adults 60 years of age or older is approximately 10% in men and 13% in women, making knee OA one of the leading causes of disability in elderly population. Today, we know that osteoarthritis is not a disease characterized by loss of cartilage due to mechanical loading only, but a condition that affects all of the tissues in the joint, causing detectable changes in tissue architecture, its metabolism and function. All of these changes are mediated by a complex and not yet fully researched interplay of proinflammatory and anti-inflammatory cytokines, chemokines, growth factors and adipokines, all of which can be measured in the serum, synovium and histological samples, potentially serving as biomarkers of disease stage and progression. Another key aspect of disease progression is the epigenome that regulates all the genetic expression through DNA methylation, histone modifications, and mRNA interference. A lot of work has been put into developing non-surgical treatment options to slow down the natural course of osteoarthritis to postpone, or maybe even replace extensive surgeries such as total knee arthroplasty. At the moment, biological treatments such as platelet-rich plasma, bone marrow mesenchymal stem cells and autologous microfragmented adipose tissue containing stromal vascular fraction are ordinarily used. Furthermore, the latter two mentioned cell-based treatment options seem to be the only methods so far that increase the quality of cartilage in osteoarthritis patients. Yet, in the future, gene therapy could potentially become an option for orthopedic patients. In the following review, we summarized all of the latest and most important research in basic sciences, pathogenesis, and non-operative treatment.
Vienna University of Technology1, Polytechnic University of Turin2, University of Barcelona3, University of Augsburg4, Masaryk University5, Academy of Sciences of the Czech Republic6, Royal Meteorological Institute7, University of Liverpool8, Stockholm University9, Norwegian Water Resources and Energy Directorate10, University of Porto11, Spanish National Research Council12, Norwegian University of Science and Technology13, National Research Council14, VRVis15, Czech Hydrometeorological Institute16, University of Freiburg17, Central Institution for Meteorology and Geodynamics18, Moscow State University19, Russian Academy of Sciences20, University of Zagreb21, University of Almería22, University of Bern23, Utrecht University24, Slovak University of Technology in Bratislava25
TL;DR: It is shown that the past three decades were among the most flood- rich periods in Europe in the past 500 years, and that this period differs from other flood-rich periods in terms of its extent, air temperatures and flood seasonality.
Abstract: There are concerns that recent climate change is altering the frequency and magnitude of river floods in an unprecedented way1. Historical studies have identified flood-rich periods in the past half millennium in various regions of Europe2. However, because of the low temporal resolution of existing datasets and the relatively low number of series, it has remained unclear whether Europe is currently in a flood-rich period from a long-term perspective. Here we analyse how recent decades compare with the flood history of Europe, using a new database composed of more than 100 high-resolution (sub-annual) historical flood series based on documentary evidence covering all major regions of Europe. We show that the past three decades were among the most flood-rich periods in Europe in the past 500 years, and that this period differs from other flood-rich periods in terms of its extent, air temperatures and flood seasonality. We identified nine flood-rich periods and associated regions. Among the periods richest in floods are 1560–1580 (western and central Europe), 1760–1800 (most of Europe), 1840–1870 (western and southern Europe) and 1990–2016 (western and central Europe). In most parts of Europe, previous flood-rich periods occurred during cooler-than-usual phases, but the current flood-rich period has been much warmer. Flood seasonality is also more pronounced in the recent period. For example, during previous flood and interflood periods, 41 per cent and 42 per cent of central European floods occurred in summer, respectively, compared with 55 per cent of floods in the recent period. The exceptional nature of the present-day flood-rich period calls for process-based tools for flood-risk assessment that capture the physical mechanisms involved, and management strategies that can incorporate the recent changes in risk. Analysis of thousands of historical documents recording floods in Europe shows that flooding characteristics in recent decades are unlike those of previous centuries.
University of Rouen1, University Medical Center Groningen2, Akdeniz University3, Aarhus University Hospital4, Dresden University of Technology5, Rappaport Faculty of Medicine6, University of Reims Champagne-Ardenne7, University Hospital of Bern8, University of Florence9, Tehran University of Medical Sciences10, Post Graduate Institute of Medical Education and Research11, Poznan University of Medical Sciences12, Sofia Medical University13, University of Münster14, University of Parma15, University of Würzburg16, St. John's University17, Medical University of Warsaw18, National Skin Centre19, University of Zagreb20, University of Milan21, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico22, University of Barcelona23, Rabin Medical Center24, St George's Hospital25, University of Modena and Reggio Emilia26, Semmelweis University27, Guy's and St Thomas' NHS Foundation Trust28, Tel Aviv Sourasky Medical Center29, Tel Aviv University30, Karadeniz Technical University31, Boston Children's Hospital32, University of Lübeck33, University of Marburg34
TL;DR: Pemphigus encompasses a group of life‐threatening autoimmune bullous diseases characterized by blisters and erosions of the mucous membranes and skin that was almost always fatal before the era of immunosuppressive treatment.
Abstract: BACKGROUND
Pemphigus encompasses a group of life-threatening autoimmune bullous diseases characterized by blisters and erosions of the mucous membranes and skin. Before the era of immunosuppressive treatment, pemphigus was almost always fatal. Due to its rarity, only few randomized controlled therapeutic trials are available. Recently, rituximab has been approved as first-line treatment for moderate and severe pemphigus vulgaris in Europe and the United States.
OBJECTIVES
The Autoimmune blistering diseases Task Force of the European Academy of Dermatology and Venereology (EADV) has initiated a throughout update of the guideline for the management of patients with pemphigus.
RESULTS
The guidelines for the management of pemphigus were updated, and the degree of consent among all task force members was included. The final version of the guideline was consented by the European Dermatology Forum (EDF) and several patient organizations.
University of Wolverhampton1, University of Zagreb2, Leeds Beckett University3, Fordham University4, University of Malta5, Aalborg University6, Chapman University7, Teesside University8, Université du Québec en Outaouais9, University of Hong Kong10, University of Seville11, University College of Northern Denmark12, Beijing Normal University13, University of Sydney14, University College West15, Auckland University of Technology16, University of Auckland17, Queen's University Belfast18, University of Indianapolis19, Umeå University20, Victoria University, Australia21, University of Newcastle22, DePauw University23, Mzumbe University24, Mid Sweden University25, Dublin City University26, RMIT University27, University of Calgary28, London Metropolitan University29, University of South Carolina30, University of Split31, University of Lincoln32, University of Melbourne33, Community College of Philadelphia34, Global University (GU)35, University of Notre Dame Australia36, University of Latvia37, Tata Institute of Social Sciences38, University of Minnesota39, University of South Africa40, International Institute of Minnesota41, University of Waikato42, Northeast Normal University43, Curtin University44, University of Ibadan45, Adekunle Ajasin University46, Zhejiang Normal University47, National University of Ireland, Galway48
TL;DR: A collection of 84 author's testimonies and workspace photographs between 18 March and 5 May 2020 was published by as discussed by the authors, with the purpose of collecting the author's workspace photographs and their testimonies.
Abstract: A collection of 84 author's testimonies and workspace photographs between 18 March and 5 May 2020
TL;DR: Well-balanced nutrition and additional anti-inflammatory PUFA-based supplementation should be encouraged in a targeted manner for individuals in need to provide better management of skin diseases but, most importantly, to maintain and improve overall skin health.
Abstract: Omega-3 (ω-3) and omega-6 (ω-6) polyunsaturated fatty acids (PUFAs) are nowadays desirable components of oils with special dietary and functional properties. Their therapeutic and health-promoting effects have already been established in various chronic inflammatory and autoimmune diseases through various mechanisms, including modifications in cell membrane lipid composition, gene expression, cellular metabolism, and signal transduction. The application of ω-3 and ω-6 PUFAs in most common skin diseases has been examined in numerous studies, but their results and conclusions were mostly opposing and inconclusive. It seems that combined ω-6, gamma-linolenic acid (GLA), and ω-3 long-chain PUFAs supplementation exhibits the highest potential in diminishing inflammatory processes, which could be beneficial for the management of inflammatory skin diseases, such as atopic dermatitis, psoriasis, and acne. Due to significant population and individually-based genetic variations that impact PUFAs metabolism and associated metabolites, gene expression, and subsequent inflammatory responses, at this point, we could not recommend strict dietary and supplementation strategies for disease prevention and treatment that will be appropriate for all. Well-balanced nutrition and additional anti-inflammatory PUFA-based supplementation should be encouraged in a targeted manner for individuals in need to provide better management of skin diseases but, most importantly, to maintain and improve overall skin health.
University of Paris1, University of Milan2, Trinity College, Dublin3, Mashhad University of Medical Sciences4, I.M. Sechenov First Moscow State Medical University5, Loyola University Medical Center6, American Heart Institute7, University of Belgrade8, Catholic University of Cordoba9, University of Zagreb10, Cleveland Clinic11, University of Genoa12, University of Bologna13, National and Kapodistrian University of Athens14, University of Cambridge15, Gazi University16, University of Perugia17, Capital Medical University18, Boston University19, University of Dammam20, Charles University in Prague21, Concord Repatriation General Hospital22, University of Ljubljana23, Academy for Urban School Leadership24, National University of Ireland, Galway25, Medical University of Vienna26, Jan Długosz University27, Medical University of Silesia28, Karolinska Institutet29, The Feinstein Institute for Medical Research30, Comenius University in Bratislava31, Wrocław Medical University32, University of Chicago33, University of Crete34, Catholic University of Leuven35, Mayo Clinic36, Peking Union Medical College37, Peking University38
TL;DR: The VAS-European Independent Foundation in Angiology/Vascular Medicine draws attention to patients with vascular disease (VD) and presents an integral strategy for the management of patients with VD or cardiovascular risk factors (VD-CVR) and COVID-19.
Abstract: COVID-19 is also manifested with hypercoagulability, pulmonary intravascular coagulation, microangiopathy, and venous thromboembolism (VTE) or arterial thrombosis. Predisposing risk factors to severe COVID-19 are male sex, underlying cardiovascular disease, or cardiovascular risk factors including noncontrolled diabetes mellitus or arterial hypertension, obesity, and advanced age. The VAS-European Independent Foundation in Angiology/Vascular Medicine draws attention to patients with vascular disease (VD) and presents an integral strategy for the management of patients with VD or cardiovascular risk factors (VD-CVR) and COVID-19. VAS recommends (1) a COVID-19-oriented primary health care network for patients with VD-CVR for identification of patients with VD-CVR in the community and patients' education for disease symptoms, use of eHealth technology, adherence to the antithrombotic and vascular regulating treatments, and (2) close medical follow-up for efficacious control of VD progression and prompt application of physical and social distancing measures in case of new epidemic waves. For patients with VD-CVR who receive home treatment for COVID-19, VAS recommends assessment for (1) disease worsening risk and prioritized hospitalization of those at high risk and (2) VTE risk assessment and thromboprophylaxis with rivaroxaban, betrixaban, or low-molecular-weight heparin (LMWH) for those at high risk. For hospitalized patients with VD-CVR and COVID-19, VAS recommends (1) routine thromboprophylaxis with weight-adjusted intermediate doses of LMWH (unless contraindication); (2) LMWH as the drug of choice over unfractionated heparin or direct oral anticoagulants for the treatment of VTE or hypercoagulability; (3) careful evaluation of the risk for disease worsening and prompt application of targeted antiviral or convalescence treatments; (4) monitoring of D-dimer for optimization of the antithrombotic treatment; and (5) evaluation of the risk of VTE before hospital discharge using the IMPROVE-D-dimer score and prolonged post-discharge thromboprophylaxis with rivaroxaban, betrixaban, or LMWH.
University of California, Santa Barbara1, University of Texas at Austin2, University of Wrocław3, Dresden University of Technology4, Opole University5, University of Tartu6, Gulu University7, Middle East University8, Stockholm University9, University of the Punjab10, University of Nigeria, Nsukka11, Istanbul University12, Franklin & Marshall College13, Norwegian University of Science and Technology14, University of Algiers15, Australian National University16, Russian Academy of Sciences17, Russian State University for the Humanities18, İzmir University of Economics19, University of Social Sciences and Humanities20, Université catholique de Louvain21, Ankara University22, Pontifical Catholic University of Peru23, Cumhuriyet University24, University of the Republic25, ISCTE – University Institute of Lisbon26, The Chinese University of Hong Kong27, National Autonomous University of Mexico28, University of Pécs29, University of Maribor30, University of Zagreb31, University of Malaya32, Central University of Finance and Economics33, University of Crete34, University of Primorska35, University of Amsterdam36, Catholic University of the Sacred Heart37, VU University Amsterdam38, University of Granada39, University of Delhi40, University of Havana41, Pontifical Catholic University of Rio de Janeiro42, University of Vienna43, Universiti Utara Malaysia44, Vilnius University45, University of British Columbia46, Centre national de la recherche scientifique47, Romanian Academy48, Slovak Academy of Sciences49, Comenius University in Bratislava50, University of Monterrey51, DHA Suffa University52, Pontifical Catholic University of Chile53, South-West University "Neofit Rilski"54, University of São Paulo55, Kyung Hee University56, University of Ljubljana57
TL;DR: Using a new 45-country sample (N = 14,399), this work attempted to replicate classic studies and test both the evolutionary and biosocial role perspectives, finding neither pathogen prevalence nor gender equality robustly predicted sex differences or preferences across countries.
Abstract: Considerable research has examined human mate preferences across cultures, finding universal sex differences in preferences for attractiveness and resources as well as sources of systematic cultural variation. Two competing perspectives-an evolutionary psychological perspective and a biosocial role perspective-offer alternative explanations for these findings. However, the original data on which each perspective relies are decades old, and the literature is fraught with conflicting methods, analyses, results, and conclusions. Using a new 45-country sample (N = 14,399), we attempted to replicate classic studies and test both the evolutionary and biosocial role perspectives. Support for universal sex differences in preferences remains robust: Men, more than women, prefer attractive, young mates, and women, more than men, prefer older mates with financial prospects. Cross-culturally, both sexes have mates closer to their own ages as gender equality increases. Beyond age of partner, neither pathogen prevalence nor gender equality robustly predicted sex differences or preferences across countries.
TL;DR: A method to determine the tissue of origin of a cancer based on whole sequencing data, using machine learning, has clinical applicability, and underscores how patterns of somatic passenger mutations encode the state of the cell of origin, and can inform future strategies to detect the source of circulating tumour DNA.
Abstract: In cancer, the primary tumour’s organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing (WGS) of 2606 tumours representing 24 common cancer types produced by the PCAWG Consortium. Our classifier achieves an accuracy of 91% on held-out tumor samples and 88% and 83% respectively on independent primary and metastatic samples, roughly double the accuracy of trained pathologists when presented with a metastatic tumour without knowledge of the primary. Surprisingly, adding information on driver mutations reduced accuracy. Our results have clinical applicability, underscore how patterns of somatic passenger mutations encode the state of the cell of origin, and can inform future strategies to detect the source of circulating tumour DNA. Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.
TL;DR: This review includes the most recent conventional procedures for brown algae polysaccharides extraction along with advanced extraction techniques (microwave-assisted extraction, ultrasound assisted extraction, pressurized liquid extraction and enzymes assisted extraction) which can effectively improve extraction process.
Abstract: Over the years, brown algae bioactive polysaccharides laminarin, alginate and fucoidan have been isolated and used in functional foods, cosmeceutical and pharmaceutical industries. The extraction process of these polysaccharides includes several complex and time-consuming steps and the correct adjustment of extraction parameters (e.g., time, temperature, power, pressure, solvent and sample to solvent ratio) greatly influences the yield, physical, chemical and biochemical properties as well as their biological activities. This review includes the most recent conventional procedures for brown algae polysaccharides extraction along with advanced extraction techniques (microwave-assisted extraction, ultrasound assisted extraction, pressurized liquid extraction and enzymes assisted extraction) which can effectively improve extraction process. The influence of these extraction techniques and their individual parameters on yield, chemical structure and biological activities from the most current literature is discussed, along with their potential for commercial applications as bioactive compounds and drug delivery systems.
Beijing Normal University1, University of Melbourne2, University of London3, Middlesex University4, Deakin University5, Seoul National University6, Sahmyook University7, University of South Australia8, University of Cambridge9, Monash University10, University of Naples Federico II11, University College London12, Shanxi University13, Chapman University14, University of Wisconsin-Madison15, University of Cyprus16, University of Illinois at Urbana–Champaign17, University of Hong Kong18, National Center for Supercomputing Applications19, Stellenbosch University20, University of Glasgow21, Maynooth University22, University of Zagreb23, Nanyang Technological University24, University of North Carolina at Chapel Hill25, University of Sydney26, University of Auckland27
TL;DR: Our minds are still racing back and forth, longing for a return to normality, trying to stitch our future to our past and refusing to acknowledge the rupture that exists as mentioned in this paper.
Abstract: Our minds are still racing back and forth, longing for a return to ‘normality’, trying to stitch our future to our past and refusing to acknowledge the rupture. But the rupture exists. And in the midst of this terrible despair, it offers us a chance to rethink the doomsday machine we have built for ourselves. Nothing could be worse than a return to normality. Historically, pandemics have forced humans to break with the past and imagine their world anew. This one is no different. It is a portal, a gateway between one world and the next. We can choose to walk through it, dragging the carcasses of our prejudice and hatred, our avarice, our data banks and dead ideas, our dead rivers and smoky skies behind us. Or we can walk through lightly, with little luggage, ready to imagine another world. And ready to fight for it.