Institution
University of Zagreb
Education•Zagreb, Grad Zagreb, Croatia•
About: University of Zagreb is a education organization based out in Zagreb, Grad Zagreb, Croatia. It is known for research contribution in the topics: Population & European union. The organization has 21769 authors who have published 50267 publications receiving 783239 citations. The organization is also known as: Zagreb University & Sveučilište u Zagrebu.
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University of Oxford1, GlaxoSmithKline2, Imperial College London3, University of Pennsylvania4, University of Lausanne5, Medical Research Council6, Wellcome Trust Sanger Institute7, University of Cambridge8, The Heart Research Institute9, University of California, San Francisco10, University of Oulu11, University of Ottawa12, University of Toronto13, King's College London14, University of Dundee15, University of Bergen16, Max Planck Society17, Ludwig Maximilian University of Munich18, University of Mainz19, Innsbruck Medical University20, University of Zagreb21, University of Edinburgh22, MedStar Washington Hospital Center23, University of Kiel24, National Research Council25, National Institutes of Health26, University of Texas MD Anderson Cancer Center27, University of Aberdeen28, University of Michigan29, University of Greifswald30, University of Split31, University of Leicester32, University of Leeds33, Guy's Hospital34, Queen Mary University of London35, University of Glasgow36
TL;DR: The Oxford-GlaxoSmithKline study (Ox-GSK) as discussed by the authors performed a genome-wide meta-analysis of SNP association with smoking-related behavioral traits and found an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19) that includes CHRNA5, CHRNA3 and CHRNB4.
Abstract: Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.
568 citations
Vienna University of Technology1, Polytechnic University of Turin2, University of Potsdam3, Swedish Meteorological and Hydrological Institute4, University of Messina5, Czech Hydrometeorological Institute6, University of Split7, University of Padua8, University of Zagreb9, University of Bologna10, University of Naples Federico II11, Moscow State University12, Dokuz Eylül University13, European Centre for Medium-Range Weather Forecasts14, University of Bath15, Slovak University of Technology in Bratislava16, Finnish Environment Institute17, University of Liverpool18, University of Architecture, Civil Engineering and Geodesy19, Technical University of Madrid20, Helmholtz Centre for Environmental Research - UFZ21, ETH Zurich22, Maynooth University23, Polish Academy of Sciences24, ODESSA25, University of Ljubljana26, Roma Tre University27, Norwegian Water Resources and Energy Directorate28, Polytechnic University of Tirana29, University of Belgrade30
TL;DR: Analysis of a comprehensive European flood dataset reveals regional changes in river flood discharges in the past five decades that are broadly consistent with climate model projections for the next century, suggesting that climate-driven changes are already happening and supporting calls for the consideration of climate change in flood risk management.
Abstract: Climate change has led to concerns about increasing river floods resulting from the greater water-holding capacity of a warmer atmosphere1. These concerns are reinforced by evidence of increasing economic losses associated with flooding in many parts of the world, including Europe2. Any changes in river floods would have lasting implications for the design of flood protection measures and flood risk zoning. However, existing studies have been unable to identify a consistent continental-scale climatic-change signal in flood discharge observations in Europe3, because of the limited spatial coverage and number of hydrometric stations. Here we demonstrate clear regional patterns of both increases and decreases in observed river flood discharges in the past five decades in Europe, which are manifestations of a changing climate. Our results—arising from the most complete database of European flooding so far—suggest that: increasing autumn and winter rainfall has resulted in increasing floods in northwestern Europe; decreasing precipitation and increasing evaporation have led to decreasing floods in medium and large catchments in southern Europe; and decreasing snow cover and snowmelt, resulting from warmer temperatures, have led to decreasing floods in eastern Europe. Regional flood discharge trends in Europe range from an increase of about 11 per cent per decade to a decrease of 23 per cent. Notwithstanding the spatial and temporal heterogeneity of the observational record, the flood changes identified here are broadly consistent with climate model projections for the next century4,5, suggesting that climate-driven changes are already happening and supporting calls for the consideration of climate change in flood risk management. Analysis of a comprehensive European flood dataset reveals regional changes in river flood discharges in the past five decades that are consistent with models suggesting that climate-driven changes are already happening.
558 citations
Vienna University of Technology1, University of Potsdam2, Swedish Meteorological and Hydrological Institute3, University of Messina4, University of Split5, University of Padua6, University of Zagreb7, University of Bologna8, University of Naples Federico II9, Polytechnic University of Turin10, Moscow State University11, Dokuz Eylül University12, University of Bath13, Slovak University of Technology in Bratislava14, Finnish Environment Institute15, Czech Hydrometeorological Institute16, University of Liverpool17, University of Architecture, Civil Engineering and Geodesy18, Technical University of Madrid19, Helmholtz Centre for Environmental Research - UFZ20, ETH Zurich21, Maynooth University22, Polish Academy of Sciences23, ODESSA24, University of Ljubljana25, Roma Tre University26, Norwegian Water Resources and Energy Directorate27, Polytechnic University of Tirana28, University of Belgrade29
TL;DR: Analysis of the timing of river floods in Europe over the past 50 years found clear patterns of changes in flood timing that can be ascribed to climate effects, and highlights the existence of a clear climate signal in flood observations at the continental scale.
Abstract: A warming climate is expected to have an impact on the magnitude and timing of river floods; however, no consistent large-scale climate change signal in observed flood magnitudes has been identified so far. We analyzed the timing of river floods in Europe over the past five decades, using a pan-European database from 4262 observational hydrometric stations, and found clear patterns of change in flood timing. Warmer temperatures have led to earlier spring snowmelt floods throughout northeastern Europe; delayed winter storms associated with polar warming have led to later winter floods around the North Sea and some sectors of the Mediterranean coast; and earlier soil moisture maxima have led to earlier winter floods in western Europe. Our results highlight the existence of a clear climate signal in flood observations at the continental scale.
557 citations
TL;DR: Experimental data strongly support an interpretation of these properties based on the creation of oxygen vacancies in the SrTiO3 substrates during the growth of the LaAlO3 layer, which opens interesting prospects for all-oxide electronics.
Abstract: We have investigated the dimensionality and origin of the magnetotransport properties of LaAlO3 films epitaxially grown on TiO2-terminated SrTiO3(001) substrates. High-mobility conduction is observed at low deposition oxygen pressures (PO2<10-5 mbar) and has a three-dimensional character. However, at higher PO2 the conduction is dramatically suppressed and nonmetallic behavior appears. Experimental data strongly support an interpretation of these properties based on the creation of oxygen vacancies in the SrTiO3 substrates during the growth of the LaAlO3 layer. When grown on SrTiO3 substrates at low PO2, other oxides generate the same high mobility as LaAlO3 films. This opens interesting prospects for all-oxide electronics.
547 citations
University of Leicester1, University of Nottingham2, Queen Mary University of London3, Medical Research Council4, Imperial College London5, King's College London6, Western General Hospital7, Uppsala University8, Wellcome Trust Sanger Institute9, University of Bristol10, St George's, University of London11, University of Helsinki12, University of Jyväskylä13, National Institutes of Health14, University of Zurich15, University of Split16, University of Zagreb17, University of Edinburgh18, University of Greifswald19, University of Gothenburg20, University of Western Australia21, Sir Charles Gairdner Hospital22, University College London23, University of London24, Glenfield Hospital25, University of Dundee26, National Institute for Health Research27, Southampton General Hospital28, Pasteur Institute29, University of Basel30, AstraZeneca31, University of Tampere32, University of St Andrews33, Health Protection Agency34
TL;DR: Genome-wide association with forced expiratory volume in 1 s (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) in the SpiroMeta consortium offers mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.
Abstract: Pulmonary function measures are heritable traits that predict morbidity and mortality and define chronic obstructive pulmonary disease (COPD). We tested genome-wide association with forced expiratory volume in 1 s (FEV(1)) and the ratio of FEV(1) to forced vital capacity (FVC) in the SpiroMeta consortium (n = 20,288 individuals of European ancestry). We conducted a meta-analysis of top signals with data from direct genotyping (n < or = 32,184 additional individuals) and in silico summary association data from the CHARGE Consortium (n = 21,209) and the Health 2000 survey (n < or = 883). We confirmed the reported locus at 4q31 and identified associations with FEV(1) or FEV(1)/FVC and common variants at five additional loci: 2q35 in TNS1 (P = 1.11 x 10(-12)), 4q24 in GSTCD (2.18 x 10(-23)), 5q33 in HTR4 (P = 4.29 x 10(-9)), 6p21 in AGER (P = 3.07 x 10(-15)) and 15q23 in THSD4 (P = 7.24 x 10(-15)). mRNA analyses showed expression of TNS1, GSTCD, AGER, HTR4 and THSD4 in human lung tissue. These associations offer mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease.
535 citations
Authors
Showing all 22096 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Harry Campbell | 150 | 897 | 115457 |
| Joseph R. Ecker | 148 | 381 | 94860 |
| Igor Rudan | 142 | 658 | 103659 |
| Nikola Godinovic | 138 | 1469 | 100018 |
| Ivica Puljak | 134 | 1436 | 97548 |
| Damir Lelas | 133 | 1354 | 93354 |
| Željko Ivezić | 129 | 344 | 84365 |
| Piotr Ponikowski | 120 | 762 | 131682 |
| Marin Soljacic | 117 | 764 | 51444 |
| Ivan Dikic | 107 | 359 | 52088 |
| Ozren Polasek | 102 | 436 | 52674 |
| Mordechai Segev | 99 | 729 | 40073 |
| Srdan Verstovsek | 96 | 1045 | 38936 |
| Segev BenZvi | 95 | 482 | 32127 |
| Mirko Planinic | 94 | 467 | 31957 |