Institution
Yonsei University
Education•Seoul, South Korea•
About: Yonsei University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Cancer. The organization has 50162 authors who have published 106172 publications receiving 2279044 citations. The organization is also known as: Yonsei.
Topics: Population, Cancer, Medicine, Thin film, Breast cancer
Papers published on a yearly basis
Papers
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TL;DR: The synthesis and binding properties of indole-based macrocycles 1 and 2 are described, which can function as a new class of synthetic receptors for anions based on H NMR chemical shifts.
Abstract: The development of synthetic receptors and chemosensors for anions has attracted much attention in recent years as the fundamental role of anions in biological and chemical processes has become increasingly understood. Biomacromolecules such as sulfate-binding proteins and a CIC chloride channel make use of hydrogen bonds as a major driving force to bind or transport anions through cell membranes. Similarly, hydrogen-bonding interactions are widely implemented for the construction of artificial receptors, and amido and ureido groups have frequently been incorporated for this purpose. 4] Furthermore, the pyrrolic NH group has also been used as a hydrogen-bond donor to an anion, as demonstrated in calixpyrroles, expanded porphyrinoids, and amidopyrroles. Herein, we describe the synthesis and binding properties of indole-based macrocycles 1 and 2, which can function as a new class of synthetic receptors for anions. The macrocycles contain a well-defined internal cavity surrounded by four indole NH hydrogen atoms, thus are capable of binding anions strongly through hydrogen-bonding interactions. More interestingly, 1 and 2 showed separate sets of H NMR signals for the free macrocycles and their complexes at room temperature in all cases and thus can serve as chemosensors for anions based on H NMR chemical shifts. The synthesis of 1 and 2 is outlined in Scheme 1. The key molecular building block 7,7’-diiodo-2,2’-biindole (4) was prepared by oxidative dimerization (Cu(OAc)2, 95%) [9]
255 citations
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TL;DR: Results show that YAP/TAZ plays multifaceted roles for EC behaviors, proliferation, junction assembly, and metabolism in sprouting angiogenesis and barrier formation and maturation and could be a potential therapeutic target for treating neovascular diseases.
Abstract: Angiogenesis is a multistep process that requires coordinated migration, proliferation, and junction formation of vascular endothelial cells (ECs) to form new vessel branches in response to growth stimuli. Major intracellular signaling pathways that regulate angiogenesis have been well elucidated, but key transcriptional regulators that mediate these signaling pathways and control EC behaviors are only beginning to be understood. Here, we show that YAP/TAZ, a transcriptional coactivator that acts as an end effector of Hippo signaling, is critical for sprouting angiogenesis and vascular barrier formation and maturation. In mice, endothelial-specific deletion of Yap/Taz led to blunted-end, aneurysm-like tip ECs with fewer and dysmorphic filopodia at the vascular front, a hyper-pruned vascular network, reduced and disarranged distributions of tight and adherens junction proteins, disrupted barrier integrity, subsequent hemorrhage in growing retina and brain vessels, and reduced pathological choroidal neovascularization. Mechanistically, YAP/TAZ activates actin cytoskeleton remodeling, an important component of filopodia formation and junction assembly. Moreover, YAP/TAZ coordinates EC proliferation and metabolic activity by upregulating MYC signaling. Overall, these results show that YAP/TAZ plays multifaceted roles for EC behaviors, proliferation, junction assembly, and metabolism in sprouting angiogenesis and barrier formation and maturation and could be a potential therapeutic target for treating neovascular diseases.
255 citations
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TL;DR: This work developed a method for evaluating Cpf1 activity, based on target sequence composition in mammalian cells, in a high-throughput manner, and defined target-sequence-dependent activity profiles of AsCpf 1, which enabled the development of a web tool that predicts the indel frequencies for given target sequences.
Abstract: A lentiviral library expressing Cpf1 guide RNAs and containing target sequences allows high-throughput profiling of highly active guide RNAs and is the basis for cindel, a webtool to predict the activity at any given target sequence.
255 citations
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02 Jan 2013
TL;DR: Measurements of charge-dependent azimuthal correlations with the ALICE detector at the LHC show a clear signal compatible with a charge- dependent separation relative to the reaction plane, which shows little or no collision energy dependence when compared to measurements at RHIC energies.
Abstract: Measurements of charge-dependent azimuthal correlations with the ALICE detector at the LHC are reported for Pb-Pb collisions at root s(NN) = 2.76 TeV. Two- and three-particle charge-dependent azimuthal correlations in the pseudorapidity range vertical bar eta vertical bar < 0.8 are presented as a function of the collision centrality, particle separation in pseudorapidity, and transverse momentum. A clear signal compatible with a charge-dependent separation relative to the reaction plane is observed, which shows little or no collision energy dependence when compared to measurements at RHIC energies. This provides a new insight for understanding the nature of the charge-dependent azimuthal correlations observed at RHIC and LHC energies. DOI: 10.1103/PhysRevLett.110.012301
255 citations
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University of Verona1, Johns Hopkins University2, Harvard University3, University of Ulsan4, Yamagata University5, Seoul National University6, Yonsei University7, Royal Liverpool University Hospital8, University of Padua9, University of Bologna10, Université libre de Bruxelles11, Third Military Medical University12, Sungkyunkwan University13, Gyeongsang National University14, Freeman Hospital15, Karolinska Institutet16, Universidade Federal do Rio Grande do Sul17, Kobe University18, University College London19, University of Barcelona20, Concord Repatriation General Hospital21, Soonchunhyang University22, Bankstown Lidcombe Hospital23, University of Turin24, Autonomous University of Barcelona25, Kansai Medical University26
TL;DR: This study supports an initial conservative management in the majority of patients with SCN, and suggests surgical treatment should be proposed only for diagnosis remaining uncertain after complete workup, significant and related symptoms or exceptionally when exists concern with malignancy.
Abstract: Objectives Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. Design Retrospective multinational study including SCN diagnosed between 1990 and 2014. Results 2622 patients were included. Seventy-four per cent were women, and median age at diagnosis was 58 years (16–99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus (5%), other symptoms (4%) and/or were asymptomatic (61%). Fifty-two per cent of patients were operated on during the first year after diagnosis (median size: 40 mm (2–200)), 9% had resection beyond 1 year of follow-up (3 years (1–20), size at diagnosis: 25 mm (4–140)) and 39% had no surgery (3.6 years (1–23), 25.5 mm (1–200)). Surgical indications were (not exclusive) uncertain diagnosis (60%), symptoms (23%), size increase (12%), large size (6%) and adjacent organ compression (5%). In patients followed beyond 1 year (n=1271), size increased in 37% (growth rate: 4 mm/year), was stable in 57% and decreased in 6%. Three serous cystadenocarcinomas were recorded. Postoperative mortality was 0.6% (n=10), and SCN9s related mortality was 0.1% (n=1). Conclusions After a 3-year follow-up, clinical relevant symptoms occurred in a very small proportion of patients and size slowly increased in less than half. Surgical treatment should be proposed only for diagnosis remaining uncertain after complete workup, significant and related symptoms or exceptionally when exists concern with malignancy. This study supports an initial conservative management in the majority of patients with SCN. Trial registration number IRB 00006477.
255 citations
Authors
Showing all 50632 results
Name | H-index | Papers | Citations |
---|---|---|---|
Younan Xia | 216 | 943 | 175757 |
Peer Bork | 206 | 697 | 245427 |
Ralph Weissleder | 184 | 1160 | 142508 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Gregory Y.H. Lip | 169 | 3159 | 171742 |
Yongsun Kim | 156 | 2588 | 145619 |
Jongmin Lee | 150 | 2257 | 134772 |
James M. Tiedje | 150 | 688 | 102287 |
Guanrong Chen | 141 | 1652 | 92218 |
Kazunori Kataoka | 138 | 908 | 70412 |
Herbert Y. Meltzer | 137 | 1148 | 81371 |
Peter M. Rothwell | 134 | 779 | 67382 |
Tae Jeong Kim | 132 | 1420 | 93959 |
Shih-Chang Lee | 128 | 787 | 61350 |
Ming-Hsuan Yang | 127 | 635 | 75091 |