Institution
Yonsei University
Education•Seoul, South Korea•
About: Yonsei University is a education organization based out in Seoul, South Korea. It is known for research contribution in the topics: Population & Cancer. The organization has 50162 authors who have published 106172 publications receiving 2279044 citations. The organization is also known as: Yonsei.
Topics: Population, Cancer, Medicine, Thin film, Breast cancer
Papers published on a yearly basis
Papers
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TL;DR: It is suggested that quercetin is an excellent inhibitor of beta-catenin/Tcf signaling in SW480 cell lines, and the reduced beta-Catenin-Tcf transcriptional activity is due to the decreased nuclear beta- catenin and Tcf-4 proteins.
327 citations
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TL;DR: In this paper, the waterline in a tidal flat in Gomso Bay, Korea is characterized and evaluated using 27 sets of Landsat thematic mapper (TM) and Earth Observing System-Terra (EOSTerra) Advanced Spaceborne Thermal Emission and Radiometer (ASTER) data.
326 citations
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TL;DR: This paper categorizes previous studies into three groups-object detection, object tracking, and action recognition-based on types of information required to evaluate unsafe conditions and acts, and provides researchers insights into advancing knowledge and techniques for computer vision-based safety and health monitoring.
326 citations
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13 Jun 2012TL;DR: AppScope is an Android-based energy metering system that monitors application's hardware usage at the kernel level and accurately estimates energy consumption and uses an event-driven monitoring method that generates low overhead and provides high accuracy.
Abstract: Understanding the energy consumption of a smartphone application is a key area of interest for end users, as well as application and system software developers. Previous work has only been able to provide limited information concerning the energy consumption of individual applications because of limited access to underlying hardware and system software. The energy consumption of a smartphone application is, therefore, often estimated with low accuracy and granularity. In this paper, we propose AppScope, an Android-based energy metering system. This system monitors application's hardware usage at the kernel level and accurately estimates energy consumption. AppScope is implemented as a kernel module and uses an event-driven monitoring method that generates low overhead and provides high accuracy. The evaluation results indicate that AppScope accurately estimates the energy consumption of Android applications expending approximately 35mW and 2.1% in power consumption and CPU utilization overhead, respectively.
326 citations
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TL;DR: In this paper, epigallocatechin-3-gallate (EGCG) was identified as a histone acetyltransferase inhibitor (HATi) with global specificity for the majority of HAT enzymes but with no activity toward epigenetic enzymes including HDAC, SIRT1, and HMTase.
Abstract: Because the p300/CBP-mediated hyperacetylation of RelA (p65) is critical for nuclear factor-kappaB (NF-kappaB) activation, the attenuation of p65 acetylation is a potential molecular target for the prevention of chronic inflammation. During our ongoing screening study to identify natural compounds with histone acetyltransferase inhibitor (HATi) activity, we identified epigallocatechin-3-gallate (EGCG) as a novel HATi with global specificity for the majority of HAT enzymes but with no activity toward epigenetic enzymes including HDAC, SIRT1, and HMTase. At a dose of 100 micromol/L, EGCG abrogates p300-induced p65 acetylation in vitro and in vivo, increases the level of cytosolic IkappaBalpha, and suppresses tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation. We also showed that EGCG prevents TNFalpha-induced p65 translocation to the nucleus, confirming that hyperacetylation is critical for NF-kappaB translocation as well as activity. Furthermore, EGCG treatment inhibited the acetylation of p65 and the expression of NF-kappaB target genes in response to diverse stimuli. Finally, EGCG reduced the binding of p300 to the promoter region of interleukin-6 gene with an increased recruitment of HDAC3, which highlights the importance of the balance between HATs and histone deacetylases in the NF-kappaB-mediated inflammatory signaling pathway. Importantly, EGCG at 50 micromol/L dose completely blocks EBV infection-induced cytokine expression and subsequently the EBV-induced B lymphocyte transformation. These results show the crucial role of acetylation in the development of inflammatory-related diseases.
325 citations
Authors
Showing all 50632 results
Name | H-index | Papers | Citations |
---|---|---|---|
Younan Xia | 216 | 943 | 175757 |
Peer Bork | 206 | 697 | 245427 |
Ralph Weissleder | 184 | 1160 | 142508 |
Hyun-Chul Kim | 176 | 4076 | 183227 |
Gregory Y.H. Lip | 169 | 3159 | 171742 |
Yongsun Kim | 156 | 2588 | 145619 |
Jongmin Lee | 150 | 2257 | 134772 |
James M. Tiedje | 150 | 688 | 102287 |
Guanrong Chen | 141 | 1652 | 92218 |
Kazunori Kataoka | 138 | 908 | 70412 |
Herbert Y. Meltzer | 137 | 1148 | 81371 |
Peter M. Rothwell | 134 | 779 | 67382 |
Tae Jeong Kim | 132 | 1420 | 93959 |
Shih-Chang Lee | 128 | 787 | 61350 |
Ming-Hsuan Yang | 127 | 635 | 75091 |