A Nuclear Long Non-Coding RNA LINC00618 Accelerates Ferroptosis in a Manner Dependent upon Apoptosis.
Zuli Wang,Xiaowen Chen,Na Liu,Ying Shi,Yating Liu,Lianlian Ouyang,Samantha Tam,Desheng Xiao,Shuang Liu,Feiqiu Wen,Yongguang Tao +10 more
TLDR
It is shown that the expression of a nuclear long non-coding RNA (lncRNA), LINC00618, is reduced in human leukemia and strongly increased by vincristine (VCR) treatment, and VCR-induced ferroptosis and apoptosis are promoted by LINC0618, and Linc00618 accelerates ferroPTosis in a manner dependent upon apoptosis.About:
This article is published in Molecular Therapy.The article was published on 2021-01-06 and is currently open access. It has received 117 citations till now.read more
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Ferroptosis-Related Long Non-Coding RNA signature predicts the prognosis of Head and neck squamous cell carcinoma.
TL;DR: In this article, the authors constructed a prognostic multilncRNA signature based on ferroptosis-related differentially expressed lncRNAs in head and neck squamous cell carcinoma (HNSCC).
Journal ArticleDOI
Emerging mechanisms and targeted therapy of ferroptosis in cancer
TL;DR: Ferroptosis is an iron and lipid reactive oxygen species (ROS)-dependent form of programmed cell death that is distinct from other forms of regulatory cell death at morphological, biological, and genetic levels as discussed by the authors.
Journal ArticleDOI
Identification and Validation of Ferroptosis-Related LncRNA Signatures as a Novel Prognostic Model for Colon Cancer
Zhiwei Wu,Zhi-Li Lu,Liang Li,Min Ma,Fei Long,Runliu Wu,Li-Hsueh Huang,Jing Chou,Kaiyan Yang,Yi Zhang,Xiaorong Li,Gui Hu,Yi Zhang,Changwei Lin +13 more
TL;DR: The proposed 4-FRL signature is a promising biomarker to predict clinical outcomes and therapeutic responses in colon cancer patients and exhibited a more powerful capacity for survival prediction than traditional clinicopathological features in colon patients.
Journal ArticleDOI
The role of ferroptosis in breast cancer patients: a comprehensive analysis.
TL;DR: In this article, the authors constructed a prognostic multigene signature based on ferroptosis-associated differentially expressed genes (DEGs) and comprehensively analyzed the role of FD-associated miRNAs, lncRNAs and immune responses.
Journal ArticleDOI
Hypoxia-induced HIF-1α/lncRNA-PMAN inhibits ferroptosis by promoting the cytoplasmic translocation of ELAVL1 in peritoneal dissemination from gastric cancer
Zaihuan Lin,Jialin Song,Yu-Er Gao,Sihao Huang,Rongzhang Dou,Panyi Zhong,Guoquan Huang,Lei Han,Jin-huan Zheng,Xinyao Zhang,Shuyi Wang,Bin Xiong +11 more
TL;DR: In this paper , the effect of hypoxia inducible factor 1 alpha (HIF-1α) on peritoneal metastasis (PM) distant metastasis was investigated and showed that upregulation of PMAN is associated with poor prognosis and PM in patients with GC.
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TL;DR: The Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives.
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