Current and future treatments for Alzheimer's disease.
TLDR
Current symptomatic treatments and new potential disease-modifying therapies for AD that are currently being studied in phase I–III trials are discussed.Abstract:
Alzheimer’s dementia (AD) is increasingly being recognized as one of the most important medical and social problems in older people in industrialized and non-industrialized nations. To date, only symptomatic treatments exist for this disease, all trying to counterbalance the neurotransmitter disturbance. Three cholinesterase inhibitors (CIs) are currently available and have been approved for the treatment of mild to moderate AD. A further therapeutic option available for moderate to severe AD is memantine, an N-methyl-D-aspartate receptor noncompetitive antagonist. Treatments capable of stopping or at least effectively modifying the course of AD, referred to as ‘disease-modifying’ drugs, are still under extensive research. To block the progression of the disease they have to interfere with the pathogenic steps responsible for the clinical symptoms, including the deposition of extracellular amyloid β plaques and intracellular neurofibrillary tangle formation, inflammation, oxidative damage, iron deregulati...read more
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Neuroprotective Activity of Asparagus racemosus Linn. Against Ethanol-Induced Cognitive Impairment and Oxidative Stress in Rats Brain:Auspicious for Controlling the Risk of Alzheimer's Disease
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Non-pharmacological cognitive intervention for aging and dementia: Current perspectives.
Jorge Alves,Rosana Magalhães,Álvaro Machado,Óscar F. Gonçalves,Adriana Sampaio,Agavni Petrosyan +5 more
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Harpagoside ameliorates the amyloid-β-induced cognitive impairment in rats via up-regulating BDNF expression and MAPK/PI3K pathways.
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Therapies for human prion diseases.
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A Rapid, Mobile Neurocognitive Screening Test to Aid in Identifying Cognitive Impairment and Dementia (BrainCheck): Cohort Study
Samantha Groppell,Karina M Soto-Ruiz,Benjamin Flores,William Dawkins,Isabella Smith,David M. Eagleman,Yael Katz +6 more
TL;DR: BrainCheck Memory provides a sensitive and specific metric for age-related cognitive impairment in older adults, with the advantages of a mobile, digital, and easy-to-use test.
References
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