Current and future treatments for Alzheimer's disease.
TLDR
Current symptomatic treatments and new potential disease-modifying therapies for AD that are currently being studied in phase I–III trials are discussed.Abstract:
Alzheimer’s dementia (AD) is increasingly being recognized as one of the most important medical and social problems in older people in industrialized and non-industrialized nations. To date, only symptomatic treatments exist for this disease, all trying to counterbalance the neurotransmitter disturbance. Three cholinesterase inhibitors (CIs) are currently available and have been approved for the treatment of mild to moderate AD. A further therapeutic option available for moderate to severe AD is memantine, an N-methyl-D-aspartate receptor noncompetitive antagonist. Treatments capable of stopping or at least effectively modifying the course of AD, referred to as ‘disease-modifying’ drugs, are still under extensive research. To block the progression of the disease they have to interfere with the pathogenic steps responsible for the clinical symptoms, including the deposition of extracellular amyloid β plaques and intracellular neurofibrillary tangle formation, inflammation, oxidative damage, iron deregulati...read more
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Journal ArticleDOI
Apelin–13 protects against memory impairment and neuronal loss, Induced by Scopolamine in male rats
Sara Gazmeh,Maryam Azhir,Leila Elyasi,Mehrdad Jahanshahi,Emsehgol Nikmahzar,Seyed Behnamedin Jameie +5 more
TL;DR: It is demonstrated that apelin–13 can protect against passive avoidance memory deficiency, and neuronal loss, induced by scopolamine in male rats, and its therapeutic potential in neurodegenerative diseases is confirmed.
Proceedings ArticleDOI
Alzheimer Screening using Drawing Test Scores
Subhorn Khonthapagdee,Sira Lownoppakul,Nattawit Chotchoey,Nuwee Wiwatwattana,Sophon Mongkolluksamee,Vera Sa-ing +5 more
TL;DR: The purpose of this research is to develop an application for a clock drawing test which is often seen as a part of the Alzheimer’s screening tests such as the Montreal Cognitive Assessment (MoCA) test and the Clock Drawing Test (CDT).
Journal ArticleDOI
Intranasal applications in Alzheimer's treatment
TL;DR: In this review, intranasal drug administration for the treatment of AD and the effects of insulin, erythropoietin, exosome, mesenchymal stem cells, and rifampicin administered by this route on AD will be discussed.
References
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