Current and future treatments for Alzheimer's disease.
TLDR
Current symptomatic treatments and new potential disease-modifying therapies for AD that are currently being studied in phase I–III trials are discussed.Abstract:
Alzheimer’s dementia (AD) is increasingly being recognized as one of the most important medical and social problems in older people in industrialized and non-industrialized nations. To date, only symptomatic treatments exist for this disease, all trying to counterbalance the neurotransmitter disturbance. Three cholinesterase inhibitors (CIs) are currently available and have been approved for the treatment of mild to moderate AD. A further therapeutic option available for moderate to severe AD is memantine, an N-methyl-D-aspartate receptor noncompetitive antagonist. Treatments capable of stopping or at least effectively modifying the course of AD, referred to as ‘disease-modifying’ drugs, are still under extensive research. To block the progression of the disease they have to interfere with the pathogenic steps responsible for the clinical symptoms, including the deposition of extracellular amyloid β plaques and intracellular neurofibrillary tangle formation, inflammation, oxidative damage, iron deregulati...read more
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DissertationDOI
A century of questions: Retrospective study of the controversy and efficacy of Alzheimer's disease models
TL;DR: This paper aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the immune response to Alzheimer's disease through a probabilistic approach.
Journal ArticleDOI
Deep Reinforcement Learning-Based Retinal Imaging in Alzheimer's Disease: Potential and Perspectives.
TL;DR: In this article , the authors discuss potential applications of DRL in using retinal imaging to study AD, and their synergistic application to unlock other possibilities, such as AD detection and prediction of AD progression.
Effect of temperature, age and lifespan extending interventions on Caenorhabditis elegans models of amyloid beta pathology
TL;DR: Overall, in characterizing an in vivo worm platform for identifying drugs and genes that impact AD, the interlinked effects of age, temperature and genetic environment on Aβ pathology are delineated.
The Effect of Inexpensive and Safe Interventions in People with Dementia
TL;DR: An increasing number of inexpensive and safe interventions, such as music therapy, dance therapy, yoga, massage therapy, storytelling and Tai Chi Chuan are utilized to treat dementia.
Journal ArticleDOI
The Role of Heme and Copper in Alzheimer’s Disease and Type 2 Diabetes Mellitus
Ishita Pal,Somdatta Ghosh Dey +1 more
TL;DR: In this paper , the impact of metal/cofactor-peptide interactions and covalent binding can alarmingly enhance and modify the toxic reactivities, oxidize vital biomolecules, significantly contribute to the oxidative stress leading to cell apoptosis, and may precede the amyloid fibrils formation by altering their native folds.
References
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Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
Reisa A. Sperling,Paul S. Aisen,Laurel A. Beckett,David A. Bennett,Suzanne Craft,Anne M. Fagan,Takeshi Iwatsubo,Clifford R. Jack,Jeffrey Kaye,Thomas J. Montine,Denise C. Park,Eric M. Reiman,Christopher C. Rowe,Eric Siemers,Yaakov Stern,Kristine Yaffe,Maria C. Carrillo,Bill Thies,Marcelle Morrison-Bogorad,Molly V. Wagster,Creighton H. Phelps +20 more
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Journal ArticleDOI
Revising the definition of Alzheimer's disease: a new lexicon.
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Journal ArticleDOI
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