Journal ArticleDOI
Disorders of iron metabolism.
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TLDR
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms, which makes it a useful component of cytochromes, oxygen-binding molecules, and many enzymes.Abstract:
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms. This capability makes it a useful component of cytochromes, oxygen-bind...read more
Citations
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Journal ArticleDOI
Relationship between iron metabolism, oxidative stress, and insulin resistance in patients with systemic lupus erythematosus.
Marcell Alysson Batisti Lozovoy,A. N. C. Simão,Sayonara Rangel Oliveira,T M V Iryioda,Carolina Panis,Rubens Cecchini,Isaias Dichi +6 more
TL;DR: This study found that oxidative stress was higher in the group of SLE patients with IR, and increased ferritin, whether caused by the inflammatory process per se or hyperinsulinaemia, can favour the redox process.
Journal ArticleDOI
Malignant Transformation and Associated Biomarkers of Ovarian Endometriosis: A Narrative Review
Liudmila M. Mikhaleva,Aleksandr I. Davydov,Olga I Patsap,Elizaveta V Mikhaylenko,Vladimir N. Nikolenko,Vladimir N. Nikolenko,Margarita E. Neganova,Sergey G. Klochkov,Siva G Somasundaram,Cecil E Kirkland,Gjumrakch Aliev +10 more
TL;DR: Despite intensive research, the origin, natural history, malignant transformation, and laboratory management of endometriosis and related diseases are not yet clearly defined and require further study in the context of advanced therapeutic strategies to provide maximal health benefits to patients.
Journal ArticleDOI
Efficacy and safety of deferasirox in myelodysplastic syndromes.
Massimo Breccia,Giuliana Alimena +1 more
TL;DR: The oral iron chelator, deferasirox, has been shown to reduce serum ferritin levels in chelation naïve and pre-treated patients and to reduce labile plasma iron, independently from the efficacy on iron overload, and the drug has an acceptable safety profile.
Journal ArticleDOI
Anemia ferropênica no adulto: causas, diagnóstico e tratamento
TL;DR: A deficiencia de ferro, especificamento a anemia ferropenica, permanece como uma das deficiencias nutricionais mais frequentes e importantes no mundo.
Book
Oral and Maxillofacial
TL;DR: This book offers a comprehensive review of the oral and maxillofacial complex and reviews the imaging of its common pathologies and includes a complete section on differential diagnoses that offers an intuitive and simplified method of reviewing pathology according to its radiographic appearance.
References
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Journal ArticleDOI
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
TL;DR: Using linkage-disequilibrium and full haplotype analysis, this paper identified a 250-kilobase region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.
Journal Article
A novel MHC class-I-like gene is mutated in patients with hereditary haemochromatosis
TL;DR: Using linkage–disequilibrium and full haplotype analysis, a region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical–by–descent in 85% of patient chromosomes is identified, containing a gene related to the MHC class I family, termed HLA–H, containing two missense alterations.
Journal ArticleDOI
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Hiromi Gunshin,Bryan Mackenzie,Urs V. Berger,Yoshimi Gunshin,Michael F. Romero,Walter F. Boron,Stephan Nussberger,John L. Gollan,Matthias A. Hediger +8 more
TL;DR: A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
Journal ArticleDOI
Prevalence of Iron Deficiency in the United States
TL;DR: Iron deficiency and iron deficiency anemia are still relatively common in toddlers, adolescent girls, and women of childbearing age and were more likely in those who are minority, low income, and multiparous.
Journal ArticleDOI
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.
Joseph V. Gray,Keith J. Johnson +1 more
TL;DR: A positional cloning strategy is undertaken to identify the causative mutation in mice with microcytic anaemia, and it is suggested that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function.
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