Journal ArticleDOI
Disorders of iron metabolism.
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TLDR
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms, which makes it a useful component of cytochromes, oxygen-binding molecules, and many enzymes.Abstract:
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms. This capability makes it a useful component of cytochromes, oxygen-bind...read more
Citations
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Journal ArticleDOI
Anemia in children with chronic kidney disease
Susan M. Koshy,Denis F. Geary +1 more
TL;DR: Pediatric nephrologists are encouraged to use current clinical practice guidelines and best evidence in conjunction with their clinical experience to optimally manage patients with anemia.
Journal ArticleDOI
Self-poisoning of Mycobacterium tuberculosis by interrupting siderophore recycling.
Christopher M. Jones,Ryan M. Wells,Ashoka V. R. Madduri,Matthew B. Renfrow,Colin Ratledge,D. Branch Moody,Michael Niederweis +6 more
TL;DR: It is demonstrated that M. tuberculosis recycles its siderophores to enable efficient iron use and may lead to the development of much-needed drugs to combat one of the world’s most deadly bacterial pathogens.
Journal ArticleDOI
Deciphering the iron isotope message of the human body
TL;DR: In this article, the authors used multicollector-inductively coupled plasma mass spectrometer (MC-ICP-MS) and double-spike thermal ionization mass spectrum (TIMS) to resolve small variations in isotopic composition even for the heavier elements such as iron.
Journal ArticleDOI
Iron homeostasis in breast cancer.
TL;DR: Progresses in iron chelation therapy in breast cancer, as a tool to fight chemotherapy resistance, are reviewed and the findings that link their deregulation with breast cancer are highlighted.
Journal ArticleDOI
Identification and transcriptome analysis of erythroblastic island macrophages
Wei Li,Wei Li,Yaomei Wang,Yaomei Wang,Huizhi Zhao,Huan Zhang,Huan Zhang,Yuanlin Xu,Shihui Wang,Shihui Wang,Xinhua Guo,Yumin Huang,Yumin Huang,Shijie Zhang,Yongshuai Han,Xianfang Wu,Charles M. Rice,Gang Huang,Patrick G. Gallagher,Avital Mendelson,Karina Yazdanbakhsh,Jing Liu,Lixiang Chen,Xiuli An,Xiuli An +24 more
TL;DR: In this article, the identity of EBI macrophages has thus far remained elusive, but it is known that Epor-eGFP is essential for erythropoiesis and Epor is expressed in numerous nonerythroid cells.
References
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Journal ArticleDOI
A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
TL;DR: Using linkage-disequilibrium and full haplotype analysis, this paper identified a 250-kilobase region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.
Journal Article
A novel MHC class-I-like gene is mutated in patients with hereditary haemochromatosis
TL;DR: Using linkage–disequilibrium and full haplotype analysis, a region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical–by–descent in 85% of patient chromosomes is identified, containing a gene related to the MHC class I family, termed HLA–H, containing two missense alterations.
Journal ArticleDOI
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Hiromi Gunshin,Bryan Mackenzie,Urs V. Berger,Yoshimi Gunshin,Michael F. Romero,Walter F. Boron,Stephan Nussberger,John L. Gollan,Matthias A. Hediger +8 more
TL;DR: A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
Journal ArticleDOI
Prevalence of Iron Deficiency in the United States
TL;DR: Iron deficiency and iron deficiency anemia are still relatively common in toddlers, adolescent girls, and women of childbearing age and were more likely in those who are minority, low income, and multiparous.
Journal ArticleDOI
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.
Joseph V. Gray,Keith J. Johnson +1 more
TL;DR: A positional cloning strategy is undertaken to identify the causative mutation in mice with microcytic anaemia, and it is suggested that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function.
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