Journal ArticleDOI
Disorders of iron metabolism.
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TLDR
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms, which makes it a useful component of cytochromes, oxygen-binding molecules, and many enzymes.Abstract:
Iron has the capacity to accept and donate electrons readily, interconverting between ferric (Fe2+) and ferrous (Fe3+) forms. This capability makes it a useful component of cytochromes, oxygen-bind...read more
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Long-Term Efficacy of Biodegradable Metal–Polymer Composite Stents After the First and the Second Implantations into Porcine Coronary Arteries
Xin Li,Wanqian Zhang,Lin Wenjiao,Hong Qiu,Yongli Qi,Xun Ma,Haiping Qi,Yao He,Hongjie Zhang,Jie Qian,Gui Zhang,Runlin Gao,Deyuan Zhang,Jiandong Ding +13 more
TL;DR: The metal-polymer composite stent (MPS) was implanted into the porcine artery and examined its degradation in vivo, and the inflammation response of MPS was acceptable 12 months after implantation, confirming the feasibility of the biodegradable MPS in second implantation in mammals.
Journal ArticleDOI
Iron and the heart: A paradigm shift from systemic to cardiomyocyte abnormalities.
TL;DR: If the authors better understand iron homeostasis in the cardiomyocyte, they may be able to develop better therapies for a variety of heart diseases to which abnormalities of ironHomeostasis may contribute, including heart failure and coronary artery disease.
Journal ArticleDOI
Bioresorbable metal scaffold for cardiovascular application: current knowledge and future perspectives.
TL;DR: The concept of bioresorbable temporary scaffolds composed of biocompatible materials has emerged as a potential alternative to permanent metal stents and is focused on metal alloys.
Journal ArticleDOI
Iron-chelating and free-radical scavenging activities of microwave-processed green tea in iron overload.
Somdet Srichairatanakool,Sakaewan Ounjaijean,Chonthida Thephinlap,Udompun Khansuwan,Chada Phisalpong,Suthat Fucharoen +5 more
TL;DR: Green tea crude extract time- and dose-dependently decreased plasma NTBI concentration and counteracted the increase of oxidative stress in both Fe 2+-EDTA-treated human plasma and erythrocytes.
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Four New Luminescent Metal–Organic Frameworks as Multifunctional Sensors for Detecting Fe3+, Cr2O72– and Nitromethane
TL;DR: In this paper, four new metal-organic frameworks, namely, {Zn(L)(dcdps)]}n (1), [ZnL)(bdc)·2H2O]·2DMF]n (2), [CdL)(oba]·0.5DMF}n,
References
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A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis
John N. Feder,Andreas Gnirke,Winston Thomas,Zenta Tsuchihashi,David A. Ruddy,A. Basava,F. Dormishian,R. Domingo,Michael C. Ellis,A. Fullan,L.M. Hinton,Norman Jones,B.E. Kimmel,Gregory S. Kronmal,Peter M. San Francisco Lauer,V.K. Lee,Deborah B. Loeb,Felipa A. Mapa,Erin E. McClelland,Nicole C. Meyer,Gabe Mintier,N. Moeller,T. E. Moore,E. Morikang,Cynthia E. Prass,Leah Quintana,Steven M. Starnes,Randall C. Schatzman,K.J. Brunke,Dennis Drayna,Neil Risch,Bruce R. Bacon,Roger K. Wolff +32 more
TL;DR: Using linkage-disequilibrium and full haplotype analysis, this paper identified a 250-kilobase region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical-by-descent in 85% of patient chromosomes.
Journal Article
A novel MHC class-I-like gene is mutated in patients with hereditary haemochromatosis
TL;DR: Using linkage–disequilibrium and full haplotype analysis, a region more than 3 megabases telomeric of the major histocompatibility complex (MHC) that is identical–by–descent in 85% of patient chromosomes is identified, containing a gene related to the MHC class I family, termed HLA–H, containing two missense alterations.
Journal ArticleDOI
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Hiromi Gunshin,Bryan Mackenzie,Urs V. Berger,Yoshimi Gunshin,Michael F. Romero,Walter F. Boron,Stephan Nussberger,John L. Gollan,Matthias A. Hediger +8 more
TL;DR: A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
Journal ArticleDOI
Prevalence of Iron Deficiency in the United States
TL;DR: Iron deficiency and iron deficiency anemia are still relatively common in toddlers, adolescent girls, and women of childbearing age and were more likely in those who are minority, low income, and multiparous.
Journal ArticleDOI
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene.
Joseph V. Gray,Keith J. Johnson +1 more
TL;DR: A positional cloning strategy is undertaken to identify the causative mutation in mice with microcytic anaemia, and it is suggested that the phenotype is a consequence of a missense mutation in Nramp2 (ref. 5), a previously identified gene of unknown function.
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